Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine

Ohishi, Tsuyoshi; Takahashi, Masaaki; Yamanashi, Akihiro; Suzuki, Daisuke; Nagano, Akira

doi:10.1007/s11999-007-0054-x

Cited by 11 publications

(13 citation statements)

References 30 publications

(38 reference statements)

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“…For the fracture healing process, the changes occurring during bone degradation (resorption) and production (formation) are more intense compared to those seen in the remodeling period in all bone fractures. [ 7 15 ] Many neurosurgeons advocate using the fusion surgery from the posterior in unstable vertebral fractures to complete the healing process with no deformation and to ensure stability. All transpedicular implants are used to provide vertebral reduction until the fracture heals and fusion occurs.…”

Section: Discussionmentioning

confidence: 99%

“…[ 27 28 29 ] These nonsurgical patients were included in the control group and they had been mobilized with a corset after a resting period varying from 1 to 3 weeks. Patients were asked to use the corset for 3 months[ 15 19 ] because previous studies have showed increased serum and urinary levels of bone production and degradation products in patients with osteoporosis;[ 7 ] osteoporotic patients were not included in the study.…”

Section: Discussionmentioning

confidence: 99%

“…As is known, the formation products produced and released by active osteoblasts are bone-specific alkaline phosphatase, type 1 collagen amino- and carboxyl-terminal and osteocalcin, all of which can be measured in serum and plasma. [ 15 30 31 ] Osteocalcin is a noncollagen protein and serum osteocalcin level increases in cases with increased bone turnover. It is synthesized by osteoblasts during the bone matrix mineralization phase.…”

Section: Discussionmentioning

confidence: 99%

“…After taking the pain under control, conservatively treated patients were mobilized following a 1–3 months of bed resting period with corset device and were advised to use the corset for 3 months. [ 15 19 ]…”

Section: Methodsmentioning

confidence: 99%

“…[ 9 10 11 12 13 14 ] Major bone formation markers are osteoblast-derived osteocalcin and bone-specific alkaline phosphatase, while the bone degradation products are urinary piridinoline (PYR), deoxypiridinoline (DPD), and serum C-telopeptide. [ 7 15 16 ]…”

Section: Introductionmentioning

confidence: 99%

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Bone turnover in vertebral fractures: Does it effect the decision of surgery?

et al. 2018

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Background and Aim:Instrumentation is commonly used in spinal surgery to stabilize the fracture. In the present study, we aimed to compare the early and late changes seen in bone production and degradation products in patients with traumatic spinal fracture who had been treated surgically or conservatively.Materials and Methods:Forty-three patients were admitted to the Neurosurgery Department with thoracolumbar or lumbar fracture in this prospective study. Patients were divided into two groups of surgically treated (n = 23) and nonsurgically/conservatively treated (n = 20) patients. The early and late changes seen in bone production and degradation products were compared in patients with traumatic spinal fracture who had been treated surgically or conservatively.Results:In conservatively treated patients, although osteocalcin level was slightly increased and deoxypiridinoline (DPD)/creatinine was slightly decreased after the treatment, the difference was not statistically significant (P = 0.08 and P = 0.539, respectively). There is no significant difference between admission time, posttreatment late period osteocalcin level, and DPD/creatinine ratio between the two group of patients (P = 0.215 and P = 0.236, respectively).Conclusion:We suggest that the healing and fusion processes in fractured vertebrae not only followed by the radiological examination but also by noninvasive biochemical changes seen in the serum levels of bone formation and resorption markers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bone turnover in vertebral fractures: Does it effect the decision of surgery?

et al. 2018

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Fracture-induced changes in biomarkers CTX, PINP, OC, and BAP—a systematic review

et al. 2019

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The importance of assessing the rate of bone turnover and the balance between bone formation and bone resorption during daily teriparatide administration for osteoporosis: a pilot study

Nakatoh

2015

J Bone Miner Metab

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This study aimed to examine the importance of simultaneously measuring bone formation and resorption markers during daily teriparatide administration. In 135 women with osteoporosis, bone mineral density (BMD) was measured at 0, 24, and 48 weeks after teriparatide administration. Bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase 5b were measured at 0, 4, 12, 24, 36, and 48 weeks. Subanalyses were performed in groups divided according to the BMD change at 48 weeks (increased and decreased groups), history of fragility fracture (acute and chronic groups), and treatment prior to teriparatide administration (alendronate, raloxifene, and naïve groups). The scatter diagram of multiple of median formation (MoMf) and multiple of median resorption (MoMr) showed that the distribution gradually spread to a high turnover by week 24. A significant correlation was observed between the rate of change in BMD at week 48 and the turnover rate [√(MoMf(2) + MoMr(2))] at week 0. Significant differences were observed in the turnover rate between the acute and chronic groups at weeks 0 and 4 and between the groups divided according to prior treatment from week 0 to 24. Because the assessment of either bone formation markers or bone resorption markers may result in erroneous data, it is necessary to assess them together during teriparatide treatment. The turnover rate at treatment initiation is a useful indicator to predict changes in BMD. When evaluating the turnover rate and balance (MoMf/MoMr), one should consider patient characteristics, including history of fragility fracture and prior treatment.

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Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine

Cited by 11 publications

References 30 publications

Bone turnover in vertebral fractures: Does it effect the decision of surgery?

Bone turnover in vertebral fractures: Does it effect the decision of surgery?

Fracture-induced changes in biomarkers CTX, PINP, OC, and BAP—a systematic review

The importance of assessing the rate of bone turnover and the balance between bone formation and bone resorption during daily teriparatide administration for osteoporosis: a pilot study

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