Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome

Clark, Simon J.; Newland, Paul; Yoxall, C W; Subhedar, Nimish V

doi:10.1007/s00431-005-0001-3

Cited by 31 publications

(36 citation statements)

References 25 publications

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“…No significant correlation was found between cTnT concentrations and gestational age, which is consistent with most literature data [10,11,12,16]. On the other hand, research by Awada et al [14], including 116 healthy newborns on the 1st day of life, revealed a significant correlation between these parameters - the highest cTnT was found in preterm newborns.…”

Section: Discussionsupporting

confidence: 81%

“…Previously performed studies revealed an increase of troponin level right after birth and maintenance of elevated concentration (comparing to adults) to the 7th or (according to other authors) 15th day of life [11,15]. In the current literature there were no studies found evaluating cTnT in infants over 2 weeks of age.…”

Section: Discussioncontrasting

confidence: 43%

“…Healthy preterm newborns presented higher troponin levels than full-terms, but the difference was not statistically significant [11]. Clark et al [16] also stated that troponin concentrations in both full-term and preterm newborns were higher than reference ranges for adults.…”

Section: Discussionmentioning

confidence: 99%

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The Evaluation of Cardiac Troponin T in Newborns

Tarkowska

Furmaga-Jabłońska

2017

Biomed Hub

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Introduction: In this paper, we evaluated the physiologic ranges of cardiac troponin T (cTnT) serum concentrations in healthy newborns. This is significant because these ranges have not been determined yet, especially for newborns older than 7 days. Cardiac troponins are widely used as diagnostic markers in adults; however, they cannot be routinely used in infants due to lack of data concerning normal values in this age group. Aim: To determine the physiologic ranges of cTnT concentrations in newborns and to evaluate the influence of factors such as age, sex, and blood saturation. Methods: The study involved 59 newborns up to 46 weeks of postmenstrual age (full-term and preterm). The exclusion criteria were severe perinatal asphyxia and presence of severe diseases. Troponin T concentrations were evaluated by the Roche CARDIAC T Quantitative Test. The obtained results were statistically analyzed by the use of the Statistica 9.0 computer program. Results: The study revealed that cTnT levels in newborns correlate with postmenstrual age, but not with chronologic or fetal age. Sex, delivery mode, and blood oxygenation did not influence cTnT concentrations in the studied patients. Conclusions: (1) Cardiac troponin T concentration depends on postmenstrual age in newborns. (2) Cardiac troponin T concentration in newborns does not depend on sex, mode of delivery, or blood saturation.

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 43%

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The Evaluation of Cardiac Troponin T in Newborns

Tarkowska

Furmaga-Jabłońska

2017

Biomed Hub

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“…1 Infants requiring inotropes had higher cTnT compared to those who were normotensive but this did not reach statistical significance possibly due to the relatively small number of subjects. Clark SJ et al 18,22 showed a similar effect of inotropes on cTnT levels. Whether the rise in cTnT in hypotensive infants is a direct result of the inotropes or cardiovascular compromise occurring before delivery is unclear.…”

Section: Biochemical Markers and Preterm Infants A El-khuffash Et Almentioning

confidence: 86%

“…9 cTnT levels are higher in premature infants with respiratory distress syndrome (RDS). 10 Biochemical markers of impaired function and ischemic damage may serve as an important screening tool in centers where echocardiography resources are limited. We hypothesized that NTpBNP and cTnT are good markers of myocardial function in preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Cardiac troponin T and N-terminal-pro-B type natriuretic peptide reflect myocardial function in preterm infants

et al. 2008

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Background: Cardiovascular compromise is increasingly recognized in preterm infants. Currently, echocardiography is the best tool to assess myocardial contractility and guide management. Elevated levels of cardiac troponin T (cTnT) and N-terminal-pro-B type natriuretic peptide (NTpBNP) are associated with poor myocardial contractility and low cardiac output in adults.Objective: To examine the range of cTnT and NTpBNP in preterm infants, to correlate NTpBNP and cTnT with echocardiographic markers of cardiac function and to assess the influence of antenatal and postnatal factors on these biochemical markers.Study Design: Plasma concentrations of cTnT and NTpBNP were measured in infants <1500 g at 12 h of age. These were correlated with simultaneous echocardiographic measures of myocardial function and output. Antenatal data, infant demographics and postnatal characteristics were prospectively recorded.Result: A total of 80 infant had samples taken and echocardiography performed. Their median (interquartile range) cTnT and NTpBNP values were 0.20 mg l À1 (0.11 to 0.40) and 1273 pmol l À1 (664 to 2798), respectively. There was a significant inverse correlation between cTnT and echocardiographic markers of myocardial function and stroke volume. NTpBNP significantly correlated with left atrial to aortic root ratio (LA:Ao). There was a weaker but significant negative correlation between NTpBNP and left ventricular (LV) function. The assays were not influenced by gestation, birth weight, gender or mode of delivery.Conclusion: cTnT and NTpBNP are correlated with echocardiographic measures of cardiac performance in preterm infants. Measurement of levels in the first hours of life may provide useful information regarding myocardial function and volume loading.

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Cardiac Troponin T in Healthy Full-Term Infants

Karlén¹,

Karlsson²,

Eliasson³

et al. 2019

Pediatr Cardiol

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In this prospective cohort study of healthy full-term infants, we hypothesized that high-sensitivity cardiac troponin T (hs-cTnT) would be elevated in cord blood, compared with adult reference values, and that it would further increase over the first days of age. Cardiac troponin T has been shown to be significantly increased in healthy full-term newborns compared with adult reference values, but there is no established reference range. Most studies of cTnT in newborns have been performed before the introduction of high-sensitivity cTnT (hs-cTnT) assay. We conducted a study including 158 full-term newborns, at Stockholm South General Hospital. High-sensitivity cTnT was analyzed in umbilical cord blood and at 2–5 days of age. Median hs-cTnT (interquartile range) in cord blood was 34(26–44) ng/L; 99th percentile 88 ng/L. Median hs-cTnT at 2–5 days of age was 92(54–158) ng/L; 99th percentile 664 ng/L. We conclude that hs-cTnT is elevated in cord blood in healthy, full-term newborn infants compared with adult reference values, and that it increases significantly during the first days of life. Our findings further underline the need of caution when using hs-cTnT as a measurement of cardiac impact in newborns.

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Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome

Cited by 31 publications

References 25 publications

The Evaluation of Cardiac Troponin T in Newborns

The Evaluation of Cardiac Troponin T in Newborns

Cardiac troponin T and N-terminal-pro-B type natriuretic peptide reflect myocardial function in preterm infants

Cardiac Troponin T in Healthy Full-Term Infants

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