Sequence Type 4821 Clonal Complex Serogroup B<i>Neisseria meningitidis</i>in China, 1978–2013

Zhu, Bingqing; Xu, Zheng; Du, Pengcheng; Xu, Li; Sun, Xiaohong; Gao, Yuan; Shao, Zhujun

doi:10.3201/eid2106.140687

Cited by 26 publications

(39 citation statements)

References 35 publications

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“…After 10 years of immunization with this vaccine, capsule-switching was noticed. Serogroup B of CC4821 increased significantly, resulting in invasive meningococcal cases, especially among infants [56].…”

Section: Ev-a71 Genotype C4a Emerged and Spread In Chinamentioning

confidence: 99%

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Liu

et al. 2018

Front. Med.

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For the past several decades, the infectious disease profile in China has been shifting with rapid developments in social and economic aspects, environment, quality of food, water, housing, and public health infrastructure. Notably, 5 notifiable infectious diseases have been almost eradicated, and the incidence of 18 additional notifiable infectious diseases has been significantly reduced. Unexpectedly, the incidence of over 10 notifiable infectious diseases, including HIV, brucellosis, syphilis, and dengue fever, has been increasing. Nevertheless, frequent infectious disease outbreaks/events have been reported almost every year, and imported infectious diseases have increased since 2015. New pathogens and over 100 new genotypes or serotypes of known pathogens have been identified. Some infectious diseases seem to be exacerbated by various factors, including rapid urbanization, large numbers of migrant workers, changes in climate, ecology, and policies, such as returning farmland to forests. This review summarizes the current experiences and lessons from China in managing emerging and re-emerging infectious diseases, especially the effects of ecology, climate, and behavior, which should have merits in helping other countries to control and prevent infectious diseases.

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Section: Ev-a71 Genotype C4a Emerged and Spread In Chinamentioning

confidence: 99%

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Liu

et al. 2018

Front. Med.

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“…At the time of writing, cc4821 isolates were the predominant cause of MenC and MenB IMD across 27 provinces in China [26]. Besides Shanghai, MenB:cc4821 were also found in 18 other provinces, with two IMD-associated MenB:ST-4821 isolates discovered clustering with MenC:ST-4821 outbreak isolates by genomic analysis [39]. These MenC:cc4821 outbreak strains accounted for the increase from <5% before 2003 to 58% during 2003-2008, resulting in an increase in IMD incidence due to MenC from 0.11 in 2000 to >5.5 during 2004-2007 per 100,000 in Hefei, China [7, 40].…”

Section: Discussionmentioning

confidence: 99%

Characterisation of carried and invasive Neisseria meningitidis isolates in Shanghai, China from 1950 to 2016: implications for serogroup B vaccine implementation

Chen

Rodrigues

Harrison

et al. 2018

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vaccine approaches evaluated. Since 1950, MenA:cc5 shifted to MenC:cc4821 then MenB:cc4821, with MenB dominating since 2009. Distinct antigens potentially beyond coverage with licensed OMV-and protein-based MenB vaccines were found. AbstractBackground Serogroup B invasive meningococcal disease (IMD) is increasing in China, little is known however, about these meningococci. This study characterises a collection of isolates associated with IMD and carriage in Shanghai and assesses current vaccine strategies.

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“…Both events suggest that N. meningitidis ST-7 serogroup A possesses sufficient ability to transform long DNA sequences. Nevertheless, significantly fewer capsular switching events occurred between serogroup A and other serogroups (16,19) than among other serogroups (5,10,20). The specificity of serogroup A might be explained partially by its genetic structure of the capsular gene locus, which is distinct from those in other serogroups.…”

Section: Discussionmentioning

confidence: 99%

“…The probability of capsular switching between different serogroups varies significantly, which impedes extensive analysis of the recombination process through comparison of the genetic characteristics between events by different serogroups. Most capsular switching events occurred between serogroups B, C, W, and Y, since their capsule polysaccharide is composed of sialic acid (5,(8)(9)(10). Rare capsular switching between serogroup A and other serogroups has been reported, although serogroup A historically has been epidemic for many years (11,12), and the vaccines incorporating its antigens have been used frequently (13)(14)(15).…”

mentioning

confidence: 99%

“…Specific genes or sequences in the locus determine the oligosaccharide components and their linkages that correspond to certain serogroups (3). Horizontal gene exchange involving the capsule gene locus can lead to capsular switching, which is an important mechanism for the organism to escape host immunity and drives the species to change in response to vaccine programs (4)(5)(6)(7).…”

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Genetic Analysis of Neisseria meningitidis Sequence Type 7 Serogroup X Originating from Serogroup A

et al. 2017

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Neisseria meningitidis causes meningococcal disease, often resulting in fulminant meningitis, sepsis, and death. Vaccination programs have been developed to prevent infection of this pathogen, but serogroup replacement is a problem. Capsular switching has been an important survival mechanism for N. meningitidis, allowing the organism to evolve in the present vaccine era. However, related mechanisms have not been completely elucidated. Genetic analysis of capsular switching between diverse serogroups would help further our understanding of this pathogen. In this study, we analyzed the genetic characteristics of the sequence type 7 (ST-7) serogroup X strain that was predicted to arise from ST-7 serogroup A at the genomic level. By comparing the genomic structures and sequences, ST-7 serogroup X was closest to ST-7 serogroup A, whereas eight probable recombination regions, including the capsular gene locus, were identified. This indicated that serogroup X originated from serogroup A by recombination leading to capsular switching. The recombination involved approximately 8,540 bp from the end of the ctrC gene to the middle of the galE gene. There were more recombination regions and strain-specific single-nucleotide polymorphisms in serogroup X than in serogroup A genomes. However, no specific gene was found for each serogroup except those in the capsule gene locus.

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Sequence Type 4821 Clonal Complex Serogroup BNeisseria meningitidisin China, 1978–2013

Abstract: These highly invasive strains probably originated from CC4821 serogroup C strains.

Cited by 26 publications

References 35 publications

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Characterisation of carried and invasive Neisseria meningitidis isolates in Shanghai, China from 1950 to 2016: implications for serogroup B vaccine implementation

Genetic Analysis of Neisseria meningitidis Sequence Type 7 Serogroup X Originating from Serogroup A

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