A total of 49 patients with hemorrhagic fever caused by HYSV were included; 8 (16.3%) patients died. A fatal outcome was associated with high viral RNA load in blood at admission, as well as higher serum liver transaminase levels, more pronounced coagulation disturbances (activated partial thromboplastin time, thrombin time), and higher levels of acute phase proteins (phospholipase A, fibrinogen, hepcidin), cytokines (interleukin [IL]-6, IL-10, interferon-γ), and chemokines (IL-8, monocyte chemotactic protein 1, macrophage inflammatory protein 1b). The levels of these host parameters correlated with viral RNA levels. Blood viral RNA levels gradually declined over 3-4 weeks after illness onset, accompanied by resolution of symptoms and laboratory abnormalities. Viral RNA was also detectable in throat, urine, and fecal specimens of a substantial proportion of patients, including all fatal cases assayed. CONCLUSIONS. Viral replication and host immune responses play an important role in determining the severity and clinical outcome in patients with infection by HYSV.

Thanks to information explosion, data for the objects of interest can be collected from increasingly more sources. However, for the same object, there usually exist conflicts among the collected multi-source information. To tackle this challenge, truth discovery, which integrates multi-source noisy information by estimating the reliability of each source, has emerged as a hot topic. Several truth discovery methods have been proposed for various scenarios, and they have been successfully applied in diverse application domains. In this survey, we focus on providing a comprehensive overview of truth discovery methods, and summarizing them from different aspects. We also discuss some future directions of truth discovery research. We hope that this survey will promote a better understanding of the current progress on truth discovery, and offer some guidelines on how to apply these approaches in application domains.

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