Sequence polymorphism of the mitochondrial DNA control region in the population of Vojvodina Province, Serbia

Zgonjanin, Dragana; Veselinović, Igor; Kubat, Milovan; Furač, Ivana; Antov, Mirjana G.; Lončar, Eva S.; Tasić, Miloš; Vuković, Radenko; Omorjan, Radovan

doi:10.1016/j.legalmed.2009.10.007

Cited by 12 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, Supporting Information Table S2). All common European haplogroups were detected with the exception of haplogroup I which is relatively rare in Europe (Richards et al, ), and their frequency distribution was in concordance with a typical European mtDNA pool (Richards et al, ) and previously published data for Serbia (Cvjetan et al, ; Zgonjanin et al, ) (Supporting Information Tables S3 and S4).…”

Section: Resultssupporting

confidence: 74%

“…Although south‐Slavic populations have been studied to date (Malyarchuk et al, ; Cvjetan et al, ; Pericic et al, ; Bosch et al, ; Zimmermann et al, ; Battaglia et al, ; Karachanak et al, ; Regueiro et al, ; Sarac et al, ), Serbian population is still genetically understudied at least at the mtDNA level which, to the best of our knowledge, has been surveyed by Cvjetan et al () and Zgonjanin et al () only. The knowledge on mtDNA variation in extant Serbian population is required for better understanding of their history and south‐Slavic identity in general.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Mitochondrial DNA perspective of Serbian genetic diversity

Davidović

Malyarchuk

Aleksić

et al. 2014

American J Phys Anthropol

View full text Add to dashboard Cite

Although south-Slavic populations have been studied to date from various aspects, the population of Serbia, occupying the central part of the Balkan Peninsula, is still genetically understudied at least at the level of mitochondrial DNA (mtDNA) variation. We analyzed polymorphisms of the first and the second mtDNA hypervariable segments (HVS-I and HVS-II) and informative coding-region markers in 139 Serbians to shed more light on their mtDNA variability, and used available data on other Slavic and neighboring non-Slavic populations to assess their interrelations in a broader European context. The contemporary Serbian mtDNA profile is consistent with the general European maternal landscape having a substantial proportion of shared haplotypes with eastern, central, and southern European populations. Serbian population was characterized as an important link between easternmost and westernmost south-Slavic populations due to the observed lack of genetic differentiation with all other south-Slavic populations and its geographical positioning within the Balkan Peninsula. An increased heterogeneity of south Slavs, most likely mirroring turbulent demographic events within the Balkan Peninsula over time (i.e., frequent admixture and differential introgression of various gene pools), and a marked geographical stratification of Slavs to south-, east-, and west-Slavic groups, were also found. A phylogeographic analyses of 20 completely sequenced Serbian mitochondrial genomes revealed not only the presence of mtDNA lineages predominantly found within the Slavic gene pool (U4a2a*, U4a2a1, U4a2c, U4a2g, HV10), supporting a common Slavic origin, but also lineages that may have originated within the southern Europe (H5*, H5e1, H5a1v) and the Balkan Peninsula in particular (H6a2b and L2a1k).

show abstract

Section: Resultssupporting

confidence: 74%

mentioning

confidence: 99%

Mitochondrial DNA perspective of Serbian genetic diversity

Davidović

Malyarchuk

Aleksić

et al. 2014

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

“…Nonetheless, if several expected mutations were not recorded, then one can predict incomplete documentation of nucleotide variants. This is the case with the two haplogroup U2e1 sequences (VP64 and VP65) from [34]: the former lacks four expected variants (16051G, 16362C, 73G, and 340T) and the latter three (16051, 16362C, 217C), which seems to reflect a reading problem at the beginning and end of the two sequenced parts rather than the effect of natural back mutations.…”

Section: Quality Control Enhanced By Haplogroupingmentioning

confidence: 92%

“…As for another instance of artificial recombination from [34], the recorded profile 16126C 16270T 16294T 16304C 73G 242T 263G 295T 309.1C 315.1C (sample VP61) testifies to J1b1a status when just HVS-II is consulted, but the HVS-I part is definitely incompatible with this assignment and suggests haplogroup T2b status instead. Further subhaplogrouping is not possible as 16270T is not found among 87 complete T2b mtDNA sequences drawn from GenBank as listed on Ian Logan's Website for haplogroup T2b.…”

Section: Quality Control Enhanced By Haplogroupingmentioning

confidence: 97%

“…Now, in the dataset provided by [34] we are seeing five samples (VP24, VP45, VP57, VP79, and VP90) of haplogroup status R0, J1c2, T1a, HV0, and U8b, respectively, for which 320T was recorded. Moreover, in two cases, this is followed by another unknown transversion variant, 324G or 328C, respectively, for which the scores in EMPOP and [11] are all zero.…”

Section: Quality Control Enhanced By Haplogroupingmentioning

confidence: 99%

See 1 more Smart Citation

Haplogrouping mitochondrial DNA sequences in Legal Medicine/Forensic Genetics

2012

View full text Add to dashboard Cite

Haplogrouping refers to the classification of (partial) mitochondrial DNA (mtDNA) sequences into haplogroups using the current knowledge of the worldwide mtDNA phylogeny. Haplogroup assignment of mtDNA control-region sequences assists in the focused comparison with closely related complete mtDNA sequences and thus serves two main goals in forensic genetics: first is the a posteriori quality analysis of sequencing results and second is the prediction of relevant coding-region sites for confirmation or further refinement of haplogroup status. The latter may be important in forensic casework where discrimination power needs to be as high as possible. However, most articles published in forensic genetics perform haplogrouping only in a rudimentary or incorrect way. The present study features PhyloTree as the key tool for assigning control-region sequences to haplogroups and elaborates on additional Web-based searches for finding near-matches with complete mtDNA genomes in the databases. In contrast, none of the automated haplogrouping tools available can yet compete with manual haplogrouping using PhyloTree plus additional Web-based searches, especially when confronted with artificial recombinants still present in forensic mtDNA datasets. We review and classify the various attempts at haplogrouping by using a multiplex approach or relying on automated haplogrouping. Furthermore, we re-examine a few articles in forensic journals providing mtDNA population data where appropriate haplogrouping following PhyloTree immediately highlights several kinds of sequence errors.

show abstract