Sequence and N-terminal Processing of the Transmembrane Protein E1 of the Coronavirus Transmissible Gastroenteritis Virus

Coronaviruses: Structure and Genome Expression

“…However, this feature is not universal among the coronaviruses; a putative Nterminal signal peptide of 17 residues has been identified for the TGEV M protein . The MHV M protein shares 86~ homology with BCV but only 35~ and 38~ with IBV and TGEV, respectively (Lapps et al, 1987;Laude et al, 1987).…”

Sequence comparison of the 5' end of mRNA 3 from transmissible gastroenteritis virus and porcine respiratory coronavirus

“…TGEV-infected cells contain, in addition to the genomic RNA (mRNA 1), six species of subgenomic mRNA observed as a 'nested' set (mRNA 2 to 7; Britton et al, 1986;Jacobs et al, 1986). The TGEV genome, except for the polymerase gene, has been cloned and sequenced from a virulent British strain, FS772/70 (Britton et al, 1987(Britton et al, , 1988a(Britton et al, , b, 1989 and from an American avirulent strain, Purdue-ll5 (Kapke & Brian, 1986;Kapke et al, 1987Kapke et al, , 1988Jacobs et al, 1987;Laude et al, 1987;. Both TGEV and PRCV have identical leader RNA sequences .…”

Localization of antigenic sites of the E2 glycoprotein of transmissible gastroenteritis coronavirus

“…The disease is especially severe in newborn animals less than 2 weeks old, in which mortality approaches 100% (Siddell et al, 1983;Sturman & Holmes, 1983;Saif & Bohl, 1986). The virus has a single-stranded, positivesense RNA genome of more than 20 kb (Brian et al, 1980; and three structural proteins: E2, N and El, of 1447, 382 and 262 amino acids, respectively (Kapke & Brian, 1986;Laude et al, 1987;Jacobs et al, 1987). The E2 glycoprotein is responsible for the induction of neutralizing antibodies (Garwes et al, 1978).…”