“…AF408195). The diversity found among Tn1546 variants containing this IS might be explained by genetic exchange between sequences containing IS1216, as IS6 family members are involved in mechanisms associated with cointegrative processes and replicative transposition (6,33). Interestingly, Tn1546 types containing IS1216 (D, X, PP-1, PP-2, PP-11, PP-13, PP15, PP-16, PP-17, PP-20, PP-23, PP-25, PP-28, and PP-29) were isolated from different sources, which might mirror wide dissemination of vancomycin resistance plasmids which have evolved by different recombinatorial events throughout different hosts.…”