Septicemic Salmonellosis in Pre Weaned Calves Caused by Salmonella dublin

Uribe, Jose Azael Zambrano; Coura, Fernanda Morcatti; Nunes, Philipe Pimenta; Silva, Marcus Vinicius Prado; Carvalho, A.Ú.; Moreira, Matheus Vilardo Lóes; Mendonça, Filipe Lucas de Melo; Salvato, Lauranne Alves; Meneses, Rodrigo Melo; Guedes, Roberto Maurício Carvalho; Lage, Andrey Pereira; Heinemann, Marcos Bryan; Filho, Elias Jorge Facury

doi:10.14737/journal.rjvp/2015/3.3.69.75

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…There are also several reports of cases where patients infected with Salmonella present with thrombosis as a complication (89–93). Thrombosis caused by Salmonella infections has also been reported in animals, such as calves (94), rats (95), and hamsters (96). Collectively, such studies demonstrate that Salmonella infections are able to induce thrombosis in a broad range of animal hosts.…”

Section: Salmonella Infections Of Mice: a Model To Evaluate The Inducmentioning

confidence: 99%

Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models

Beristain‐Covarrubias

et al. 2019

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Thrombosis is a common consequence of infection that is associated with poor patient outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is induced, maintained and resolved are poorly understood, as is the contribution thrombosis makes to host control of infection and pathogen spread. The key difference between infection-associated thrombosis and thrombosis in other circumstances is a stronger inflammation-mediated component caused by the presence of the pathogen and its products. This inflammation triggers the activation of platelets, which may accompany damage to the endothelium, resulting in fibrin deposition and thrombus formation. This process is often referred to as thrombo-inflammation. Strikingly, despite its clinical importance and despite thrombi being induced to many different pathogens, it is still unclear whether the mechanisms underlying this process are conserved and how we can best understand this process. This review summarizes thrombosis in a variety of models, including single antigen models such as LPS, and infection models using viruses and bacteria. We provide a specific focus on Salmonella Typhimurium infection as a useful model to address all stages of thrombosis during infection. We highlight how this model has helped us identify how thrombosis can appear in different organs at different times and thrombi be detected for weeks after infection in one site, yet largely be resolved within 24 h in another. Furthermore, we discuss the observation that thrombi induced to Salmonella Typhimurium are largely devoid of bacteria. Finally, we discuss the value of different therapeutic approaches to target thrombosis, the potential importance of timing in their administration and the necessity to maintain normal hemostasis after treatment. Improvements in our understanding of these processes can be used to better target infection-mediated mechanisms of thrombosis.

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Section: Salmonella Infections Of Mice: a Model To Evaluate The Inducmentioning

confidence: 99%

Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models

Beristain‐Covarrubias

et al. 2019

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“…Hypophysitis in domestic ruminants most commonly develops secondary to systemic or regional diseases, including but not limited to, extension of post-dehorning sinusitis and osteomyelitis, 6 extension of controlled suckling device–induced rhinitis, 2 and bacterial septicemia. 18 The susceptibility of the hypophysis to inflammation and infection in domestic ruminants is attributable to its dense fenestrated capillary network lacking a blood-brain barrier, integration with the extensive portal blood system within the median eminence, and proximity to the RERM. The pars distalis is the most vascularized region of the hypophysis, composed of an interconnected capillary portal system required for circulation of releasing hormones from the hypothalamus that stimulates release of trophic hormones produced by cells of the adenohypophysis.…”

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confidence: 99%

Systemic proliferative arteriopathy and hypophysitis in a cow with chronic ovine herpesvirus 2–induced malignant catarrhal fever

et al. 2022

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Malignant catarrhal fever (MCF) is a severe, systemic, lymphoproliferative disease affecting domestic ruminants, caused by a group of MCF viruses in the genus Macavirus. Infection of cattle and bison with ovine herpesvirus 2 (OvHV2) is economically significant in North America. Sheep are the reservoir host of the virus, and only rarely manifest disease. Cattle and bison, however, frequently have lymphoproliferation, mucosal ulceration, and systemic vasculitis. OvHV2-induced MCF in cattle and bison is often fatal, with clinical recovery reported only rarely. Chronic cases are uncommon, but vascular changes of variable severity and ocular lesions have been described. Here we present a case of chronic MCF in a cow with proliferative arteriopathy, systemic vasculitis, and OvHV2-associated hypophysitis. We demonstrated OvHV2 nucleic acid in affected tissues with in situ hybridization.

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