Septicaemia from prolonged intravenous infusions.

Thong, M L; Tay, Lay

doi:10.1136/adc.50.11.886

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…Nine (15.8%) of 57 cases were treated with chloramphenicol, either as monotherapy in 4 cases (44.4%) [37,64,69,72] or as part of combination therapy with sulfisoxazole in 3 cases (33.3%) [4], sulfadiazine in 1 case (11.1%) [69] and tetracycline/kanamycin/nalidixic acid in the last case (11.1%) [66]. Six (66.7%) of them were cured and clinical improvement was noted in two (22.2%), one of whom died of a reason irrelevant to the infection.…”

Section: Case Reportsmentioning

confidence: 99%

Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence

Avgeri

Matthaiou

Dimοpoulos

et al. 2009

International Journal of Antimicrobial Agents

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Section: Case Reportsmentioning

confidence: 99%

Therapeutic options for Burkholderia cepacia infections beyond co-trimoxazole: a systematic review of the clinical evidence

Avgeri

Matthaiou

Dimοpoulos

et al. 2009

International Journal of Antimicrobial Agents

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“…A nationwide epidemic of infusion sepsis in 1970 and 1971 generated widespread awareness of this hazard and focused attention on the manufacturing process (10,18). Investigations of other epidemics have shown that contamination also can occur during admixture or administration of infusate (5, 7,8,24,28). Bacteria implicated in these epidemics have been primarily members of the tribe Klebsielleae.…”

Section: Discussionmentioning

confidence: 99%

Safety of refrigerated storage of admixed parenteral fluids

Weil

Arnow

1988

J Clin Microbiol

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Many hospital pharmacies are reluctant to store admixed parenteral fluids longer than 24 to 48 h because of concern about possible microbial contamination. We evaluated the safety of prolonged refrigerated storage of admixtures by culturing mixtures in 471 bags prepared routinely in a hospital pharmacy and stored at 4°C for up to 15 days. Low-level contamination (1 CFU per bag) was found in 3 of 253 solutions of saline and/or glucose into which nonantibiotic additives had been injected. None of 171 saline and/or glucose solutions with antibiotic additives or 47 parenteral nutrition fluids was culture positive. The risk of contamination did not increase with duration of storage, and none of 107 bags stored .5 days was culture positive. Laboratory studies to measure growth of bacteria and fungi in glucose infusate and parenteral nutrition solutions confirmed that storage at 4°C suppresses growth. Eight of twelve bacterial isolates grew in glucose solutions at 25°C, while none grew at 4°C. Of 13 species of bacteria and fungi inoculated in parenteral nutrition fluids, 8 proliferated at 25°C and none proliferated at 4°C. We conclude that refrigerated storage of parenteral fluids for up to 1 week following admixture, as permitted by Centers for Disease Control guidelines, does not appear to increase the risk of microbial contamination when standard aseptic procedures for admixing and storage are followed.

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