Septic arthritis of the knee due to Raoultella ornithinolytica

Venus, Kevin; Vaithilingam, Sarah; Bogoch, Isaac I.

doi:10.1007/s15010-016-0930-y

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…Most Raoultella species are broadly susceptible to antibiotics but show intrinsic resistance to ampicillins because of the presence of beta-lactamases 1,10 . Seng et al 2 reported that resistance to TMP-SMX is 10%.…”

Section: Discussionmentioning

confidence: 99%

Posttraumatic Patellar Osteomyelitis due to Raoultella ornithinolytica

Graham

Jeray

2023

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Case: A 59-year-old woman sustained a comminuted patellar fracture after a fall from standing. The injury was treated with open reduction and internal fixation 7 days from initial injury. Seven weeks postoperatively, she developed a swollen, painful, and draining knee. Workup demonstrated Raoultella ornithinolytica. She underwent surgical debridement and antibiotic treatment. Conclusion:This is an unusual presentation of patellar osteomyelitis with R. ornithinolytica. Early identification, treatment with appropriate antimicrobial therapy, and consideration of surgical debridement are important in patients presenting with pain, swelling, and erythema after surgery.Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSCC/C28).

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Section: Discussionmentioning

confidence: 99%

Posttraumatic Patellar Osteomyelitis due to Raoultella ornithinolytica

Graham

Jeray

2023

JBJS Case Connector

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“…Interestingly, when present, Raoultella often occupied a large proportion of the total bacterial read count. This is the first study to describe the presence of DNA from the genus Raoultella in RA synovial fluid samples, however, two major species are capable of causing infections in man: Raoultella ornithinolytica and Raoultella planticola , and have been shown to be capable of reaching the articular joint compartment [61–63]. Moreover, Raoultella are characterised as histamine generating bacteria [64], a key pro-inflammatory molecule found in RA blood, articular cartilage, synovial fluid and synovial tissue [65].…”

Section: Discussionmentioning

confidence: 99%

Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects

2019

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The colonisation of specific body sites in contact with the external environment by microorganisms is both well-described and universally accepted, whereas, the existence of microbial evidence in other “classically sterile” locations including the blood, synovial space, and lungs, is a relatively new concept. Increasingly, a role for the microbiome in disease is being considered, and it is therefore necessary to increase our understanding of these. To date, little data support the existence of a “synovial fluid microbiome”.MethodsThe presence and identity of bacterial and fungal DNA in the synovial fluid of rheumatoid arthritis (RA) patients and healthy control subjects was investigated through amplification and sequencing of the bacterial 16S rRNA gene and fungal internal transcribed spacer region 2 respectively. Synovial fluid concentrations of the cytokines IL-6, IL-17A, IL22 and IL-23 were determined by ELISA.ResultsBacterial 16S rRNA genes were detected in 87.5% RA patients, and all healthy control subjects. At the phylum level, the microbiome was predominated by Proteobacteria (Control = 83.5%, RA = 79.3%) and Firmicutes (Control = 16.1%, RA = 20.3%), and to a much lesser extent, Actinobacteria (Control = 0.2%, RA = 0.3%) and Bacteroidetes (Control = 0.1%, RA = 0.1%). Fungal DNA was identified in 75% RA samples, and 88.8% healthy controls. At the phylum level, synovial fluid was predominated by members of the Basidiomycota (Control = 53.9%, RA = 46.9%) and Ascomycota (Control = 35.1%, RA = 50.8%) phyla. Statistical analysis revealed key taxa that were differentially present or abundant dependent on disease status.ConclusionsThis study reports the presence of a synovial fluid microbiome, and determines that this is modulated by disease status (RA) as are other classical microbiome niches.

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“…These patients were considered to be at a great risk for this particular infection. Septic arthritis and sepsis in general [6,7] is possibly a major clinical consequence of this bacterial infection [8,9]. Children, especially in immunocompromised conditions are vulnerable in manifesting clinically significant complicated infections [10].…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of positive Raoultella Ornithinolytica and Staphylococcus hominis cultures in a post lobectomy patient. A case report

Papakanderaki

Kanakakis

Goule

et al. 2018

Monaldi Arch Chest Dis

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Raoultella ornithinolytica is an encapsulated, Gram-negative, nonmotile aerobic rob which was reclassified from Klebsiella genus belonging to the family of Enterobacteriaceae. It is a rare human infection and few cases have been reported in post thoracotomy patients. Here we present a case of a left lower lobectomy patient that was complicated by pleural effusion, high fever with positive sputum cultures of Raoultella ornithinolytica and positive pleural fluid cultures of Staphylococcus hominis. The disease is related with aquatic life poisoning. There are few cases reported and even fewer postoperatively. The infection is rare in humans therefore the bacteria is still underreported.

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Septic arthritis of the knee due to Raoultella ornithinolytica

Cited by 12 publications

References 6 publications

Posttraumatic Patellar Osteomyelitis due to Raoultella ornithinolytica

Posttraumatic Patellar Osteomyelitis due to Raoultella ornithinolytica

Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects

Clinical significance of positive Raoultella Ornithinolytica and Staphylococcus hominis cultures in a post lobectomy patient. A case report

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