Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats

Liu, Qing; Zhang, Min; Qin, Wangjun; Wang, Yanting; Li, Yuling; Li, Jing; Li, Jun-Xu; Lawrence, Andrew J; Liang, Jing

doi:10.1016/j.brainres.2012.03.027

Cited by 16 publications

(20 citation statements)

References 50 publications

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“…From the first day of self-administration, morphine animals exhibited significantly higher locomotor activity and reduced defecation compared with those of saline animals. These results are consistent with previous studies that demonstrated the psychomotor activation effects of morphine (Jing et al, 2011; Liu et al, 2012; Wang et al, 2014; Wei et al, 2016). This is important to note, because the number of infusions was similar between the MSA and SSA groups with a FR1 schedule of reinforcement.…”

Section: Discussionsupporting

confidence: 93%

Altered Acoustic Startle Reflex, Prepulse Inhibition, and Peripheral Brain-Derived Neurotrophic Factor in Morphine Self-Administered Rats

Lee

Park

Lin

et al. 2016

IJNPPY

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Background:Previous studies suggested that opiate withdrawal may increase anxiety and disrupt brain-derived neurotrophic factor function, but the effects of i.v. morphine self-administration on these measures remain unclear.Methods:Adult male Sprague-Dawley rats were implanted with a catheter in the jugular vein. After 1 week of recovery, the animals were allowed to self-administer either i.v. morphine (0.5 mg/kg per infusion, 4 h/d) or saline in the operant conditioning chambers. The acoustic startle reflex and prepulse inhibition were measured at a baseline and on self-administration days 1, 3, 5, and 7 (1- and 3-hour withdrawal). Blood samples were collected on self-administration days 3, 5, and 7 from separate cohorts of animals, and the levels of brain-derived neurotrophic factor and corticosterone were assayed using the enzyme-linked immunosorbent assay method.Results:Compared with the saline group, the morphine self-administration group showed hyper-locomotor activity and reduced defecation during the self-administration. The morphine self-administration increased acoustic startle reflex at 1-hour but not 3-hour withdrawal from morphine and disrupted prepulse inhibition at 3-hour but not 1-hour withdrawal. The blood brain-derived neurotrophic factor levels were decreased in the morphine self-administration group at self-administration days 3 and 5, while the corticosterone levels remained unchanged throughout the study.Conclusions:The current findings suggest that spontaneous withdrawal from i.v. morphine self-administration may have transient effects on acoustic startle, sensorimotor gating, and peripheral brain-derived neurotrophic factor levels, and these changes may contribute to the adverse effects of opiate withdrawal.

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Section: Discussionsupporting

confidence: 93%

Altered Acoustic Startle Reflex, Prepulse Inhibition, and Peripheral Brain-Derived Neurotrophic Factor in Morphine Self-Administered Rats

Lee

Park

Lin

et al. 2016

IJNPPY

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“…In addition, spontaneous locomotor activity in rats was not impaired by BNO at doses effective in inhibiting alcohol drinking, demonstrating that the suppression of alcohol‐drinking behavior cannot be ascribed to motor function impairment or sedation (Li et al, 2014). Finally, the CPP paradigm was used to evaluate the conditioned reinforcing effect of BNO in rats (Li et al, 2014; Liu et al, 2012). We found that BNO treatment at 70 mg/kg, an effective dose as demonstrated above, did not result in either preference or aversion for the BNO‐paired compartment, preliminarily suggesting that the effects on alcohol drinking likely do not result from interoceptive properties of BNO.…”

Section: Discussionmentioning

confidence: 99%

“…Here, CPP procedures were utilized to evaluate the conditioned reinforcing profile of BNO. We used an unbiased device comprised of 3 different chambers (a middle chamber of 14 cm × 23 cm × 20 cm, L × W × H; 2 side chambers of 28 cm × 23 cm × 20 cm, L × W × H) separated by a retractable guillotine door (Liu et al, 2012; Zhang et al, 2012). The side chambers were defined as distinguishable conditioning rooms with 2 somatosensory cues (visual: 5 radially arranged or 4 squarely arranged low‐power lightbulbs; tactile: stainless steel rod or stainless steel mesh floor).…”

Section: Methodsmentioning

confidence: 99%

Brucine N‐Oxide Reduces Ethanol Intake and Preference in Alcohol‐Preferring Male Fawn‐Hooded Rats

Wei

Gong

et al. 2020

Alcoholism Clin & Exp Res

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Background: Alcohol use disorder places a heavy burden on global public health systems and thus is in urgent need of improved pharmacotherapies. Previously, our group has demonstrated that 30 mg/kg of the indole alkaloid brucine significantly attenuates alcohol-drinking behavior; however, the high toxicity, poor water solubility, short half-life, and limited therapeutic window of brucine restrain its clinical application as an antialcoholism medication. We subsequently hypothesized that the oxide of brucine (brucine Noxide) would produce a similar behavioral effect without the risk profile associated with brucine.Methods: Male Fawn-Hooded rats with high innate alcohol preference underwent 2-bottle choice procedures (Experiments 1 to 3). Experiment 1 examined the effects of 7 daily BNO injections of 0, 30, 50, or 70 mg/kg (s.c.) on voluntary alcohol consumption (n = 9/group). Experiment 2 evaluated the impact of a single dose of 0 or 70 mg/kg BNO on the increased alcohol intake induced by a 4-day alcohol deprivation (n = 8/group). Experiment 3 tested the effect of 7 daily BNO injections of 0 or 70 mg/ kg (s.c.) on sucrose preference (n = 6/group). Experiment 4 measured the median lethal dose (LD50) values of BNO and brucine to compare their acute toxicity in rats. Experiment 5 tested whether BNO (0, 30, 50, and 70 mg/kg, s.c.) affected locomotor activity using an open-field paradigm (n = 8/group). Finally, Experiment 6 evaluated the possible conditioned rewarding effects of 0, 30, 50, and 70 mg/kg BNO using the conditioned place preference paradigm (n = 6/group).Results: BNO administration dose-dependently attenuated alcohol consumption without affecting food intake, total fluid consumption, or the natural preference for a sucrose solution, with 70 mg/kg BNO reducing consumption by 22.8%. A single dose of 70 mg/kg BNO significantly inhibited the alcohol deprivation effect. The LD50 values of BNO and brucine in rats were determined to be 1,103.5 AE 177.0 mg/kg and 264.6 AE 17.7 mg/kg, respectively. Finally, BNO administration did not affect spontaneous locomotor activity or induce a place preference.Conclusions: BNO may help to control excessive alcohol use and should be considered a treatment strategy for future study and development. are contribute equally to this work.

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“…Locomotor activity was measured in 4 chambers (49 cm×49 cm×59 cm) situated in sound-attenuating cabinets (96 cm×96 cm×96 cm) using Digbehv spontaneous activity monitors (DigBehv-LG, Shanghai Jiliang Software Technology Co Ltd, Shanghai, China) [29] . The total distance of horizontal locomotor activity was recorded with a video camera located above the chamber and analyzed with the Digbehv software (Version 2.0, Shanghai Jiliang Software Technology Co Ltd, Shanghai, China).…”

Section: Locomotor Activity Testmentioning

confidence: 99%

“…The present study used an unbiased paradigm as described in previous studies [29,31,32] . FH/Wjd rats were conditioned in the CPP apparatus, which consisted of three distinct chambers (two end-chambers of 28 cm×23 cm×20 cm, L×W×H, and one middle chamber of 14 cm×23 cm×20 cm, L×W×H) separated by a retractable guillotine door.…”

Section: Conditioned Place Preference (Cpp) Testmentioning

confidence: 99%

Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats

Liu

Gong

et al. 2014

Acta Pharmacol Sin

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Aim: Brucine (BRU) extracted from the seeds of Strychnos nux-vomica L is glycine receptor antagonist. We hypothesize that BRU may modify alcohol consumption by acting at glycine receptors, and evaluated the pharmacodynamic profiles and adverse effects of BRU in rat models of alcohol abuse. Methods: Alcohol-preferring Fawn-Hooded (FH/Wjd) rats were administered BRU (10, 20 or 30 mg/kg, sc). The effects of BRU on alcohol consumption were examined in ethanol 2-bottle-choice drinking paradigm, ethanol/sucrose operant self-administration paradigm and 5-d ethanol deprivation test. In addition, open field test was used to assess the general locomotor activity of FH/Wjd rats, and conditioned place preference (CPP) was conducted to assess conditioned reinforcing effect. Results: In ethanol 2-bottle-choice drinking paradigm, treatment with BRU for 10 consecutive days dose-dependently decreased the ethanol intake associated with a compensatory increase of water intake, but unchanged the daily total fluid intake and body weight. In ethanol/sucrose operant self-administration paradigms, BRU (30 mg/kg) administered before each testing session significantly decreased the number of lever presses for ethanol and the ethanol intake, without affecting the number of sucrose (10%) responses, total sucrose intake, and the number of lever presses for water. Acute treatment with BRU (30 mg/kg) completely suppressed the deprivation-induced elevation of ethanol consumption. Treatment with BRU (10, 20, and 30 mg/kg) did not alter locomotion of FH/Wjd rats, nor did it produce place preference or aversion. Conclusion: BRU selectively decreases ethanol consumption with minimal adverse effects. Therefore, BRU may represent a new pharmacotherapy for alcoholism.

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Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats

Cited by 16 publications

References 50 publications

Altered Acoustic Startle Reflex, Prepulse Inhibition, and Peripheral Brain-Derived Neurotrophic Factor in Morphine Self-Administered Rats

Altered Acoustic Startle Reflex, Prepulse Inhibition, and Peripheral Brain-Derived Neurotrophic Factor in Morphine Self-Administered Rats

Brucine N‐Oxide Reduces Ethanol Intake and Preference in Alcohol‐Preferring Male Fawn‐Hooded Rats

Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats

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