Sepsis: who will shoot first? Pharma or diagnostics?

Textoris, Julien; Gordon, Anthony

doi:10.1007/s00134-018-5234-5

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The presence of immune dysfunction was linked to a commensurate increase in risk of infection, from 14% for patients with no dysfunction to 59% for patients with dysfunction of all three markers [182]. This study demonstrated the feasibility of standardized flow cytometry from multiple sites [183].…”

Section: Human Leukocyte Antigen D-related-hla-dr Expression On Monoc...mentioning

confidence: 87%

Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19

Udovičić

Stanojević

Djordjević

et al. 2021

JCM

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Immune cells and mediators play a crucial role in the critical care setting but are understudied. This review explores the concept of sepsis and/or injury-induced immunosuppression and immuno-inflammatory response in COVID-19 and reiterates the need for more accurate functional immunomonitoring of monocyte and neutrophil function in these critically ill patients. in addition, the feasibility of circulating and cell-surface immune biomarkers as predictors of infection and/or outcome in critically ill patients is explored. It is clear that, for critically ill, one size does not fit all and that immune phenotyping of critically ill patients may allow the development of a more personalized approach with tailored immunotherapy for the specific patient. In addition, at this point in time, caution is advised regarding the quality of evidence of some COVID-19 studies in the literature.

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Section: Human Leukocyte Antigen D-related-hla-dr Expression On Monoc...mentioning

confidence: 87%

Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19

Udovičić

Stanojević

Djordjević

et al. 2021

JCM

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“…In summary, we do need an immunoscope, i.e., a way to monitor quantitatively all key aspects of the immune response overtime, in ICU, because the host immune response (1) is clearly responsible for the pathophysiology of sepsis and septic shock, (2) is highly dynamic, (3) but also heterogeneous among patients, and (4) its complexity (number of players, and complex interplay of immune functions) prevent the use of a single biomarker. The ability to assess the immune status of critically ill patients will facilitate the adoption of adaptive clinical trials, allowing enrichment and stratification of patients who will be helped most by specific management approaches and treatments [22]. It is quite disappointing to have reached such detailed knowledge about the role of the immune system in critical illness, without having translated that into clinical practice.…”

Section: Secondary Infecɵonsmentioning

confidence: 99%

Immunity check should be performed for all patients with septic shock? Yes

Textoris

2020

Intensive Care Med

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Epigenetic Biomarkers for Human Sepsis and Septic Shock: Insights from Immunosuppression

et al. 2020

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Sepsis is a life-threatening condition that occurs when the body responds to an infection damaging its own tissues. Sepsis survivors sometimes suffer from immunosuppression increasing the risk of death. To our best knowledge, there is no ‘gold standard’ for defining immunosuppression except for a composite clinical end point. As the immune system is exposed to epigenetic changes during and after sepsis, research that focuses on identifying new biomarkers to detect septic patients with immunoparalysis could offer new epigenetic-based strategies to predict short- and long-term pathological events related to this life-threatening state. This review describes the most relevant epigenetic mechanisms underlying alterations in the innate and adaptive immune responses described in sepsis and septic shock, and their consequences for immunosuppression states, providing several candidates to become epigenetic biomarkers that could improve sepsis management and help predict immunosuppression in postseptic patients.

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Sepsis: who will shoot first? Pharma or diagnostics?

Cited by 3 publications

References 15 publications

Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19

Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19

Immunity check should be performed for all patients with septic shock? Yes

Epigenetic Biomarkers for Human Sepsis and Septic Shock: Insights from Immunosuppression

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