Sepsis por Ewingella americana en lactante con nefropatía congénita

Carrascosa, E. Cobos; Torres, A. Daza; Aguilera, Álvaro; Sánchez, F. Giménez

doi:10.1016/j.anpedi.2013.12.004

Cited by 3 publications

(5 citation statements)

References 9 publications

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“…The first case was a 7 months old immunocompromised male with a history of congenital nephrotic syndrome who presented with bacteremia secondary to E. americana. The patient ultimately became septic and passed away (12). The second and third cases were in previously healthy children who developed pneumonia (11) and conjunctivitis (13), respectively, with E. americana and recovered fully after antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

First Case of Ewingella americana Meningitis in a Term Newborn: A Rare but Real Pathogen

et al. 2020

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Section: Discussionmentioning

confidence: 99%

First Case of Ewingella americana Meningitis in a Term Newborn: A Rare but Real Pathogen

et al. 2020

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“…Interestingly, Ea infections are even rarer in children than in adults. A case of sepsis in an infant with congenital nephropathy [15] and a case of acute conjunctivitis [16] have been described. This is the first case of CAP due to Ea documented in an otherwise healthy child.…”

Section: Discussionmentioning

confidence: 99%

What is the role of Ewingella americana in humans? A case report in a healthy 4-year-old girl

et al. 2019

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Background Ewingella americana ( Ea ) is a Gram-negative, lactose-fermenting, oxidase-negative and catalase-positive bacterium that was first described in 1983 as a new genus and species in the family Enterobacteriaceae . It is not known whether Ea is a true pathogen or simply an opportunistic infectious agent, as most of the cases have been described in patients at risk. Case presentation A 4-year-old girl described here was hospitalized due to a productive cough over the previous 3 weeks and a fever > 38 °C associated with tachypnea over the previous 2 days. Her familial and personal medical histories were negative for relevant diseases, including respiratory infections. At admission, she was febrile (axillary temperature 39.2 °C) and had dyspnea with retractions, grunting and nasal flaring. A chest examination revealed fine crackling rales in the left upper field associated with bilateral wheezing. A chest X-ray revealed segmental consolidation of the lingula of the left lung. Laboratory tests revealed leukocytosis (15.,800 white blood cells/mm 3 with 50.3% neutrophils), a slight increase in serum C-reactive protein (11.9 mg/L) and normal procalcitonin values (< 0.12 ng/mL). A nasopharyngeal swab culture did not reveal viral or bacterial respiratory pathogens, including atypical bacteria. A blood culture revealed the presence of a Gram-negative, lactose-fermenting rod that was oxidase negative and catalase positive. The isolate was identified by means of the VITEK®2 identification system (bioMérieux, Firenze, Italy) as Ea . This identification was confirmed by sequencing the 16 s ribosomal deoxyribonucleic acid (rDNA). The pathogen was sensitive to aminoglycoside, fluoroquinolones, carbapenems, cefotaxime, and ceftazidime but was intermediate against sulfametoxazole/trimethoprim and resistant to amoxicillin-clavulanic acid, fosfomycin, and oxacillin. The child was immediately treated orally with amoxicillin-clavulanic acid and erythromycin. Based on the results of a blood culture and sensitivity tests, the amoxicillin-clavulanic acid medication was stopped after 3 days. Erythromycin was continued for a total of 10 days, and the child was discharged after 3 days in the hospital. Follow-up visit 1 month later did not reveal any respiratory problems. Conclusion This case shows that Ea infections in healthy subjects are mild even in pediatric age, and the need for antibiotic therapy is debated. Cases occurring in subjects with underlying chronic disease can be significantly more complicated and require appropriate antibiotic therapy.

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“…El síndrome nefrótico congénito es una condición rara que se de ne como el desarrollo del síndrome nefrótico dentro de los primeros tres meses de vida. La mayoría de los casos de SNC primario ocurren en bebés con ascendencia nlandesa [4,14,15]. El inicio posterior a los tres meses de vida y un año se denomina síndrome nefrótico infantil [1,9].…”

Section: Discussionunclassified

“…Los riñones NPHS1 son grandes y en las ecografías se aumenta la ecogenicidad cortical, causando que el borde corticomedular sea indistinguible [10]. Esta alteración es particularmente común en Finlandia, por lo que se le ha dado el nombre de SNC de tipo nlandés [4].…”

Section: Discussionunclassified

“…El síndrome nefrótico congénito (SNC) es una enfermedad grave y poco frecuente, con una amplia variabilidad en su forma de presentación, por lo general resistente a corticoides. Tiene factores genéticos y hereditarios implicados, lo cual puede estar asociado o no a factores determinantes o facilitadores, siendo el de tipo nlandés el más frecuente [4,8]. Para su diagnóstico, es preciso la realización de estudios clínicos, bioquímicos, histológicos y genéticos [8].…”

Section: Introductionunclassified

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Síndrome nefrótico congénito debutando con enfermedad de cambios mínimos, a propósito de un caso

Varticovsky

Cardoza

Castillo

et al. 2021

Rev. Colomb. Nefrol.

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El síndrome nefrótico, es la glomerulopatía primaria más frecuente en Pediatría, es una patología que se caracteriza por presencia de proteinuria, hipoalbuminemia, edema e hipercolesterolemia. Se trata de un neonato con antecedentes de prematuridad y hospitalización al nacer en quien posterior a múltiples infecciones recurrentes con evolución tórpida durante estancia hospitalaria y edema generalizado se sospecha síndrome nefrótico congénito obteniendo paraclínicos positivos y biopsia renal que reporta enfermedad de cambios mínimos. El síndrome nefrótico congénito es una entidad poco frecuente sin embargo presenta alta morbimortalidad, tiene diversas formas de presentación clínica e histológica y el manejo suele ser difícil con poca respuesta a corticoides. La presencia de síndrome nefrótico congénito es inusual, sin embargo, presenta alta mortalidad y muchas secuelas posteriores, siendo la enfermedad renal crónica la más temida, por lo cual es importante sospechar en recién nacidos con infecciones recurrentes asociado a presencia de edema generalizado, un manejo precoz puede ayudar a evitar secuelas y mejorar la calidad de vida del paciente y la familia.

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Sepsis por Ewingella americana en lactante con nefropatía congénita

Cited by 3 publications

References 9 publications

First Case of Ewingella americana Meningitis in a Term Newborn: A Rare but Real Pathogen

First Case of Ewingella americana Meningitis in a Term Newborn: A Rare but Real Pathogen

What is the role of Ewingella americana in humans? A case report in a healthy 4-year-old girl

Síndrome nefrótico congénito debutando con enfermedad de cambios mínimos, a propósito de un caso

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