Sepsis-associated pathways segregate cancer groups

Abstract

Background: Sepsis and cancer are both leading causes of death, and occurrence of any one, increases the likelihood of the other. While cancer patients are susceptible to sepsis, survivors of sepsis are also susceptible to develop certain cancers. This mutual dependence for susceptibility suggests shared biology between the two disease categories. Earlier analysis had revealed a cancer-related pathway to be up-regulated in Septic Shock (SS), an advanced stage of sepsis. This has motivated a more comprehensive comparison of the transcriptomes of SS and cancer.

Scaffold compound L971 exhibits anti‐inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways

“…Beyond their important regulatory functions in immune response, STAT3 and NFκB family members are ubiquitously expressed in most types of cancer and involved in tumorigenesis, progressions and metastasis 47,48 . Moreover, sepsis is significantly associated with increased risk for many cancers including chronic myeloid leukaemia, myelodysplastic syndrome, acute myeloid leukaemia, cancers of the cervix, liver, lung, rectum and colon 49 . To date, multiple NFκB inhibitors were evaluated in clinical to treat various cancer types including prostate, renal and colorectal cancers, melanoma and leukaemia whereas the JAK/STAT inhibitors were also tested for their anti‐cancer efficacy in ovarian, brain, prostate, pancreatic and neurologic cancers and multiple myeloma 6 .…”

Prevalence and factors associated with sepsis and septic shock in oncological patients in intensive therapy

“…In addition to the factors identified in this study, international investigations highlight other clinical and microbiological aspects that may increase the chance of sepsis and septic shock in cancer patients, such as chemotherapy-induced neutropenia (44)(45)(46)(47) ; the presence of biological markers -myeloid-derived granulocytic suppressor cells (G-MDSCs) after esophageal surgery (46) ; solid tumors often associated with infections of the gastrointestinal tract (47) ; and bacteria such as Staphylococcus spp., E. coli, K. pneumoniae, E. faecalis and S. aureus (48) .…”

Elucidating immune-related gene transcriptional programs via factorization of large-scale RNA-profiles

“…Some immunological states may be shared by a variety of conditions. For example, the severe immune dysregulation and inflammation, 13 , 14 observed in sepsis samples may inform immune cell proliferation, inflammatory signaling, and cellular dysfunction and exhaustion in tumor immune microenvironment (TIME).…”