Sepsis affects most routine and cell population data (CPD) obtained using the Sysmex XN‐2000 blood cell analyzer: neutrophil‐related CPD NE‐SFL and NE‐WY provide useful information for detecting sepsis

Abstract

Sepsis patients demonstrated significant changes in routine and CPD items related to RBC, neutrophils, lymphocytes, and platelets when compared to NCs. Increase in CPD items NE-SFL and NE-WY, which may indicate neutrophil immaturity or activation, could be useful for the detection of sepsis patients, in conjunction with currently used surrogate sepsis biomarkers. However, these items did not efficiently contribute to the discrimination of sepsis severity or predict mortality.

Immature granulocyte count on the new Sysmex XN-9000: performance and diagnosis of sepsis in the intensive care unit

“…Indeed, the diagnostic performance measured in the present study was lower than that reported by Ansari-Lari and others, (8,17) and this is clearly attributable to the fact that we used a more suitable control population (i.e., ICU patients) rather than a group of healthy controls. Unlike in our study, moreover, Ansari-Lari did not use the validated criteria of the International Sepsis Definition Conference (4) for diagnosing sepsis.…”

Clinical significance of cell population data (CPD) on Sysmex XN-9000 in septic patients with our without liver impairment

“…These basically include IG (10,11), or the high fluorescence lymphocyte cells (HFLCs) count, a parameter which is usually related to the presence of activated lymphocytes, plasma cells and other blast cells (12). Additional research parameters characterizing different leukocyte populations [i.e., cell population data (CPD)] such as neutrophils (NE), lymphocytes (LY) and monocytes (MO) have recently became available, and preliminary observations suggest that their assessment may be useful in the diagnosis of myelodysplastic syndromes (13,14) and sepsis (15).…”

Contribution of the new XN‐1000 parameters NEUT‐RI and NEUT‐WY for managing patients with immature granulocytes

“…Neutrophil Reactive Intensity, expressed in fluorescence intensity, is representative of the mean fluorescence of the neutrophils and can therefore be related to the activation or immaturity of the population. It is derived from NEUT-Y on XE instruments and few data are available relating the value of this parameter to infection disease/sepsis management [4,5]. NEUT-WY represents the width of the neutrophil scattergram in the WDF channel on the fluorescence axis.…”