Sepsis-3: How useful is the new definition?

Sinha, Sharmili; Ray, Banambar

doi:10.4103/joacp.joacp_335_16

Cited by 10 publications

(6 citation statements)

References 4 publications

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“…According to this definition, they have also proposed some diagnostic criteria that are going to be further analyzed in the next section. However, there is still some debate regarding the Sepsis-3 definition as it shows inconsistencies [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Postoperative sepsis after colorectal surgery: a prospective single-center observational study and review of the literature

Mulita¹,

Liolis²,

Akinosoglou³

et al. 2022

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Introduction: Postoperative sepsis represents a significant problem in colorectal surgery patients. Aim: To identify the etiology as well as the risk factors associated with the development of postoperative sepsis, based on prospective data of patients undergoing colorectal surgery at a single large-volume institution.Material and methods: Between November 2019 and February 2021, 141 patients underwent an elective operation for colorectal cancer at a tertiary hospital center. The following variables were recorded for each patient: age, gender, American Society of Anesthesiologists Classification (ASA class), duration of surgery, surgical approach, comorbidities (diabetes, cardiovascular disease, respiratory disease). Univariate analysis was performed using χ 2 tests for categorical variables.Results: A total of 69 males and 72 females were enrolled. Postoperative sepsis was diagnosed in 18 (12.77%) cases, with anastomotic leakage being the most frequent cause (3.55%). There was no statistically significant difference in the presence of sepsis among patients when gender, surgical approach, duration of surgery, and respiratory disease were taken into account. Sixty-nine patients were > 65 years old, with sepsis being statistically significant in this group (p = 0.034). Furthermore, patients with ASA class ≤ 2 developed postoperative sepsis less frequently than patients with advanced ASA scores (p = 0.008). Diabetes and cardiovascular disease also reach statistical significance; sepsis was more frequent in this group of patients (p = 0.013 and p = 0.009, respectively).Conclusions: Following colorectal cancer procedures, postoperative sepsis was significantly more common among patients over 65 years old, ASA score > 2, and also with associated comorbidities such as diabetes and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

“…These patients should have at least two of the following criteria: hypotension, with systolic blood pressure ≤ 100 mm Hg, altered mental status, tachypnea with a respiratory rate of 22/min or greater. However, qSOFA is not considered a diagnostic criterion of sepsis but a screening tool [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Postoperative sepsis after colorectal surgery: a prospective single-center observational study and review of the literature

Mulita¹,

Liolis²,

Akinosoglou³

et al. 2022

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“…11 This condition in the literature is known as a euthyroid sick syndrome or nonthyroidal illness syndrome. 12 Several studies have shown that septic patients who have no previous history of thyroid disease have deficient levels of the hormone T3. Kumar et al and Padhi et al showed that in the acute phase of sepsis, blood levels of T3 hormone were deficient even though there was no history of thyroid disease in the previous patient.…”

Section: Introductionmentioning

confidence: 99%

Correlation of SOFA Score and Hormone Value for Predicting 28-days Mortality for Septic Patients

Zulkifli

Haloho

Maritska

et al. 2022

JACR

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Introduction. Sepsis is a group of symptoms of organ dysfunction that can be life-threatening because of dysregulation of body response toward ongoing infection. Organ dysfunction in sepsis can be measured by Sequential Organ Failure Assessment (SOFA) and T3 hormone. The study was aimed to identify the correlation of T3 in predicting mortality of 28 days patients in Intensive Care Unit RSMH Palembang. Method. This study design is cohort prospective. The inclusion criteria consist of a patient diagnosed with sepsis and septic shock in the Intensive Care Unit, 18-64 years old. Patients with a history of thyroid disease, pregnant or post-pregnancy, the patient admitted in referral from other hospitals, and patients with a history of psychiatry medication and thyroid medication were excluded. Data collected is the patient whose stay in Intensive Care Unit RSMH followed in 28 days from January 2021 until the sample was fulfilled (39 samples). Analyzing data was SPSS version 23 with chi-square analysis and Fisher's Exact to identify the relationship. Pearson correlation to identify correlation coefficient, and Medical application to measure AUC, cutoff value, sensitivity, and specificity. Result. The result showed that age (p=0,445). gender (p=1,00), need of ICU (p=0,228), isolation-nonisolation ward (p=0,437) didn't have any significant relationship toward mortality. SOFA score correlate statistically with positive correlation and medium strength (0,633) toward mortality of sepsis patient (p=0,000). T3 hormon correlate positively with medium strength (0,514) toward mortality of sepsis patient (p=0,001). T3 hormone toward SOFA correlate negatively (-0,365) with significant correlation (p=0,22). T3 hormone has AUC 0,291 with sensitivity 3,3% and specificity 67,7%. Conclusion. T3 hormone has a significant negative correlation to mortality in sepsis patients but cannot be used to predict mortality with a low AUC value (0,291).

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“…Quick sequential organ failure assessment (qSOFA) is a screening tool to identify sepsis outside the ICU such as emergency departments, hospital wards and community health care (Sinha & Ray, 2018). The qSOFA score is used to quickly and easily determine patients at high risk of sepsis (Singer et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Accuracy of ESI triage, qSOFA Score And Their Combinations As Predictor of Sepsis Prognosis

2022

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Penelitian ini bertujuan untuk mengidentifikasi kombinasi ESI, qSOFA dan kombinasinya sebagai prediktor prognosis sepsis. Metode penelitian yang digunakan adalah desain penelitian retrospektif untuk membandingkan akurasi ESI dengan qSOFA. Data yang digunakan adalah seluruh rekam medis pasien di RS Sumberglagah Mojokerto, Jawa Timur, Indonesia. Kriteria inklusi adalah rekam medis pasien berusia > 18 tahun, data lengkap meliputi tekanan darah, HR, RR, SaO2 dan kadar ESI pasien. Dari total 2394 MR pasien selama periode tersebut, hanya 112 MR yang memenuhi kriteria inklusi dan kemudian dimasukkan dalam penelitian ini, terdiri dari 42 hasil survival dan 70 unsurvival. Diantara kelompok unsurvival, ada 41 (58,6%) memiliki ESI 1-2, dan 29 (41,4%) ESI 3-5; juga 21 (30%) qSOFA 2, dan 49 (70%) qSOFA<2. Sensitivitas ESI adalah 71,4% dan spesifisitasnya adalah 28,6% untuk memprediksi unsurvive outcome, sedangkan sensitivitas qSOFA adalah 30% dan spesifisitasnya 85,7%. Kombinasi keduanya untuk memprediksi prognosis tidak meningkat secara signifikan (p>0,05). Sensitivitas kombinasi ESI dan qSOFA adalah 61,9% dan spesifisitasnya adalah 52,9%. Skor ESI rendah tampaknya lebih relevan untuk memprediksi risiko hasil yang tidak bertahan hidup daripada skor qSOFA tinggi, tetapi skor qSOFA rendah lebih relevan untuk memprediksi risiko hasil kelangsungan hidup daripada skor ESI tinggi. Kombinasi keduanya tidak secara signifikan meningkatkan akurasi prediktor prognosis.

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Sepsis-3: How useful is the new definition?

Cited by 10 publications

References 4 publications

Postoperative sepsis after colorectal surgery: a prospective single-center observational study and review of the literature

Postoperative sepsis after colorectal surgery: a prospective single-center observational study and review of the literature

Correlation of SOFA Score and Hormone Value for Predicting 28-days Mortality for Septic Patients

Accuracy of ESI triage, qSOFA Score And Their Combinations As Predictor of Sepsis Prognosis

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