Seprafilm reduces adhesions to polypropylene mesh

Baptista, Michael L.; Bonsack, Margaret E.; Delaney, John P.

doi:10.1067/msy.2000.106810

Cited by 81 publications

(82 citation statements)

References 10 publications

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“…With the increasing popularity of laparoscopic ventral hernia repair, many combination meshes have been designed for intraperitoneal placement [1][2][3][4]. However, the prosthetic mesh grafts used in the repair of abdominal wall and inguinal hernias may become contaminated during the perioperative period or it may be necessary to place the prosthesis in an infected body compartment.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the adherence of E.Coli and S. Aureus to ten different prosthetic mesh grafts: In vitro experimental study

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Comparison of the adherence of E.Coli and S. Aureus to ten different prosthetic mesh grafts: In vitro experimental study

et al. 2010

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“…Although the ID group had higher adhesion intensity score than the HA group, no statistically significant difference was found between these two groups. The critical period for adhesion formation is the peritoneal healing phase that lasts approximately one week (21,22,23). During this phase, HA remains in the peritoneal cavity for 7 days while ID remains for just 4 days (4-10,12), which may be the reason for higher adhesion intensity observed in the ID group, despite not being statistically significant.…”

Section: Discussionmentioning

confidence: 69%

“…Hyaluronic acid-phosphate buffered normal saline solution used intra-operatively, especially in gynecologic surgeries, was examined in multi-centric studies and was found to be effective in the prevention of adhesions (22). Many recent studies reported that bioresorbable membrane (Seprafilm®) composed of hyaluronic acid and carboxymethyl-cellulose was effective and reliable in preventing adhesions (23).…”

Section: Discussionmentioning

confidence: 99%

Comparison of 4% icodextrin and auto-crosslinked hyaluronic acid gel in terms of efficacy and cost effectivity in preventing postoperative abdominal adhesions

Baskonus¹,

Maralcan²,

Gökalp³

et al. 2013

Gaziantep Med J

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This experimental study was designed to compare the effects and costs of 4% icodextrin and hyaluronic acid in intraabdominal adhesion formation in rats. This study included 30 healthy Wistar albino rats, each weighing 250-300 gr. Following cecal-ileal abrasion to rats in each group, the following treatments were applied: Group 1 (control, n:10) 5 ml saline irrigation; Group 2 (n:10) 5 ml 4% icodextrin solution; Group 3 (n:10) 3 ml auto-crosslinked hyaluronic acid gel. After 14 days, following a second operation, adhesion intensity scoring, histopathological assessment (inflammation, fibrosis) and costs were compared between groups. The lowest postoperative adhesion intensity score was found in the group 3 and the highest score was found in the group 1 (p=0.028). Group 3 had a non-significantly lower adhesion intensity score than group 2 (p>0.05). In terms of inflammation and fibrosis, group 2 had the lowest score, but there were no significant differences between all the groups (p>0.05). In terms of cost, 4% icodextrin is less expensive than hyaluronic acid. The results demonstrated that both hyaluronic acid and 4% icodextrin are similarly effective in reducing postoperative intraabdominal adhesions. In addition, 4% icodextrin is more cost-effective, which can be an advantage for clinical studies.

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“…These materials are applied as a patch either above or below the fascia. If the mesh comes into contact with abdominal organs, serious intraabdominal adhesions form [1][2][3][4][5][6][7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

“…Ventral hernias occur due to a variety of reasons either as a primary condition or as a result of complications arising during surgical procedures (incisional hernia) [1][2][3][4][5] . In situations where there is insufficient healthy tissue or when the hernia rupture is very large, prosthetic materials are used in treatment.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Efficacy of Dimethyl Sulfoxide (DMSO) and Synovial Fluid in the Prevention of Peritoneal Adhesions: Experimental Rabbit Model

Kılıç¹,

KILIÇ²,

Yayla³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryThe purpose of this study was to compare the efficacy of dimethyl sulfoxide and synovial fluid (SF) in the prevention of peritoneal adhesions that might develop in connection with the use of mersilen mesh in a ventral hernia model created experimentally in rabbits. The forty rabbits used in the study were divided into four groups of ten. The operation was conducted under intrathecal anesthesia induced with ketamine HCl (20 mg/kg intrathecal) following xylazin HCl (5 mg/kg intramuscular) sedation. A median skin incision was made in rabbits placed on the operating table in the supine position. Then, a defect 2 cm in diameter was created on the linea alba. The defect was repaired with mersilen mesh which had been previously prepared in the shape of a disk. Until the 7 th day after the operation, group I was given 10 ml saline (S) and 1.5 g/kg DMSO, group II was given 7 ml saline, 3 ml synovial fluid (SF) and 1.5 g/kg DMSO, group III was given 7 ml saline and 3 ml SF while group IV (control: C) was given only 10 ml saline. All of these were administered intraperitoneally. At the end of the 10th day, the presence and extent of peritoneal adhesion was checked using Jenkins' (1983) visual adhesion scale by performing a relaparotomy. All of the data obtained from the study was analyzed statistically using the Minitab-16 package program. Tissue samples from the region where the graft was performed were evaluated under a light microscope by staining them with the Hematoxilen-Eosin (HE) and Crossman triple stain method. The results of the adhesion scale were evaluated nonparametrically and statistical calculations were performed with the KruskalWallis test. No statistical difference was found between the groups (P>0.05). The results of histopathological examination revealed that the tissue which covered the graft in all of the groups was fibrous tissue. However, it was determined that the fibrosis was weaker in the DMSO group than it was in the SF-DMSO, SF and S groups. In the end, it was concluded that synovial fluid is effective in preventing postoperative peritoneal adhesions in rabbits in light of both relaparotomic, macroscopic findings and histopathological findings.

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Seprafilm reduces adhesions to polypropylene mesh

Cited by 81 publications

References 10 publications

Comparison of the adherence of E.Coli and S. Aureus to ten different prosthetic mesh grafts: In vitro experimental study

Comparison of the adherence of E.Coli and S. Aureus to ten different prosthetic mesh grafts: In vitro experimental study

Comparison of 4% icodextrin and auto-crosslinked hyaluronic acid gel in terms of efficacy and cost effectivity in preventing postoperative abdominal adhesions

A Comparison of the Efficacy of Dimethyl Sulfoxide (DMSO) and Synovial Fluid in the Prevention of Peritoneal Adhesions: Experimental Rabbit Model

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