Separation of some platinum(II) complexes by ionic strength gradient on a solvent-generated ion-exchange sorbent

Macka, Mirek; Borák, J.; Kiss, František

doi:10.1016/0021-9673(91)85135-3

Cited by 19 publications

(7 citation statements)

References 6 publications

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“…In order to evaluate the drug in pharmaceutical dosage forms and in clinical situations and to optimize therapeutic regimens, analytical methods capable of separating the drug from its excipients or from its individual biotransformation products and detecting these species at therapeutically relevant levels are required [2]. Several efforts have been made so far that include derivative spectrophotometry [3][4][5][6], detection by phosphorescence of cisplatin in urine and plasma [7], atomic absorption spectrometry [8][9][10], electroanalytical methods [11], and highperformance liquid chromatography methods [12][13][14][15][16][17][18][19][20][21]. The structure of cisplatin hydrochloride is shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Simple and Sensitive Spectrometric Method for Estimation of Cisplatin Hydrochloride in Tablet Dosage Forms: Application to Dissolution Studies

Basotra

Singh

Gulati

2013

ISRN Analytical Chemistry

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Cisplatin hydrochloride is an important chemotherapeutic drug for cancer treatment. It has a low molar absorptivity in the UV region and has no fluorescence. Therefore, a selective derivatizing reaction is required for its detection in bulk and pharmaceutical dosage form if detection by UV spectrophotometry is sought. In view of this, a simple, accurate, rapid, and cost-effective spectrophotometric method for its estimation has been developed by the complexation of the drug with ortho-phenylene diamine and monitoring the absorbance of formed green color at 706 nm. The method has been validated and successfully applied for the assay and dissolution studies of cisplatin hydrochloride tablets. The method demonstrated good linearity over the range from 0.4 to 1.4 μg/mL with a correlation coefficient of 0.9999. The accuracy of the method was 99.98%. The precision demonstrated relative standard deviation of less than 2.5%. The developed method was successfully applied for dissolution studies of sustained release tablets of cisplatin with a cumulative release of 86.7% in 12 hours. The proposed method can be applied in routine quality control in the pharmaceutical industries since it is precise, accurate, simple, and economic.

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Section: Introductionmentioning

confidence: 99%

Development and Validation of a Simple and Sensitive Spectrometric Method for Estimation of Cisplatin Hydrochloride in Tablet Dosage Forms: Application to Dissolution Studies

Basotra

Singh

Gulati

2013

ISRN Analytical Chemistry

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“…Similarly, Cisplatin and its hydrolytic and decomposition products are separated on octadecylsilica (Silasorb SPH C 18) coated with octanesulphonate using a mobile phase containing octane sulphonate and dihydrogenephosphate with pH 4.3 and variable ionic strength gradient [68]. The separation of cationic hydrolytic products from the parent Cisplatin was successfully achieved on sorbent modified by solutions containing 5 mM heptane or hexane sulphonate and 10 mM sodium acetate with pH 4.60.…”

Section: Hplc Of Platinum Anti-cancer Drugs Their Derivatives and Spmentioning

confidence: 99%

“…Table III) and their positively charged hydrolysis products can be separated in one run by micellar electrokinetic chromatography in aqueous solutions containing dodecylsulphate. Such treatment is preferred to the HPLC applied earlier [68]. Neutral complexes were separated from their hydrolysis products by the micellar effect.…”

Section: Cze Of Platinum Drugsmentioning

confidence: 99%

A survey of the potential of the high performance liquid chromatography and capillary zone electrophoresis for the determination of platinum and platinum group metals

Sommer

Vlašánková

2000

Chromatographia

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Various platinum group metals (PGMs) can be separated in the form of complexes with monodentate ligands, ion associates or chelates by high performance liquid chromatography (HPLC) or capillary zone electrophoresis (CZE). Ion associates of anionic monodentate PGM complexes with low and high-molecular-mass ammonium cations give satisfactory results in ion interaction HPLC on reversed phase silica in the presence of CH3CN or CH30H modifiers. PGM chelates often show considerable shortcomings due to kinetic hindrance during their formation and must be formed prior to HPLC application. Capillary zone electrophoresis (CZE) brings some new aspects to the separation of PGMs in addition to increasing separation speed and miniaturization of the system. Both methods can be successfully used for the treatment of platinum anti-cancer drugs, their organic impurities, hydrolytic products or metabolites in body fluids. Representative examples are discussed in this paper.

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“…Macka and co-workers [21,22] managed to separate different kinds of platinum species by using anion and cation exchangers together in the running buffer. The disadvantage of this method is the use of an ionic gradient and a heated column.…”

Section: Cl\ /Nh 3 Ci\ /Nh a /Pt\ Nh:~pt\ci/ Nh 3 CL Ci/pt\cimentioning

confidence: 99%

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

1999

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We have developed a simple, rapid, selective and sensitive method for detecting the antitumour agent cisdiamminedichloroplatinum (II) (cisplatin) (CDDP) and its toxic impurities trans-diamminedichloroplatinum (II) (transplatin) (TDDP) amminetri-chloroplatinat (ATCP) anion using HPLC in one run. By using 4methyl-2-thiouracil (MTU) as a derivatizing agent, new compounds have been formed from the Pt compounds and separated on a ~-Bondapak C1s column with isocratic elution and detection at 315 nm. Reactant concentration, methanol content, pH and the reaction time on yield of derivatives were investigated and the optimum conditions for the detection response were defined. The derivatives of each of the three platinum compounds formed in an acetate buffer solution containing 40 % (v/v) methanol and 0.9 % KC1 solution at pH 3.7 and ambient temperature were only stable for one hour.

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Separation of some platinum(II) complexes by ionic strength gradient on a solvent-generated ion-exchange sorbent

Cited by 19 publications

References 6 publications

Development and Validation of a Simple and Sensitive Spectrometric Method for Estimation of Cisplatin Hydrochloride in Tablet Dosage Forms: Application to Dissolution Studies

Development and Validation of a Simple and Sensitive Spectrometric Method for Estimation of Cisplatin Hydrochloride in Tablet Dosage Forms: Application to Dissolution Studies

A survey of the potential of the high performance liquid chromatography and capillary zone electrophoresis for the determination of platinum and platinum group metals

Determination of cisplatin, transplatin and amminetri-chloroplatinate by high performance liquid chromatography in one run using 4-methyl-2-thiouracil as derivatizing agent

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