Separation of healthy and early osteoarthritis by automatic quantification of cartilage homogeneity

Abstract

These data demonstrate that the distribution of components of the articular matrix precedes erosion, as measured by cartilage homogeneity related to water concentration. We show that homogeneity was able to separate early OA from healthy individuals in contrast to traditional volume and JSW quantifications. These data suggest that cartilage homogeneity quantification may be able to quantify early biochemical changes in articular cartilage prior to cartilage loss and thereby provide better identification of patients for OA trials who may respond better to medicinal intervention of some treatments. In addition, this study supports the feasibility of using low-field MRI in clinical studies.

Spatial analysis of magnetic resonance and relaxation times improves classification between subjects with and without osteoarthritis

“…The rationale behind this study is that the loading patterns in the knee articulation are region specific leading to nonuniform cartilage degeneration, 21 that T 1 and T 2 maps show a laminar distribution that probably gets disrupted with OA, 14 and that the spatial organization of cartilage T 1 and T 2 is also affected with OA and can be detected with texture analysis. 20,22 In comparison to other works, this study is the first to simultaneously analyze laminar and texture analyses of T 1 and T 2 values.…”

Feasibility of high-resolution one-dimensional relaxation imaging at low magnetic field using a single-sided NMR scanner applied to articular cartilage

“…In an early work, the superiority of T 1 vs. T 2 contrast in cartilage imaging at a low magnetic field strength of 0.15 T was pointed out [18]; dedicated devices for extremities have been presented [19], and routines for osteoarthritis prediction at 0.18 T were discussed [20]. Different aspects of low-field and high-field cartilage imaging are reviewed in [21,22].…”

The measurement of biomechanical properties of porcine articular cartilage using atomic force microscopy

“…nanometer) scale, from where they spread to higher levels of the cartilage hierarchical architecture and cause progressively irreversible structural and functional damages. There are several non-invasive (Burstein and Gray, 2006;Li et al, 2007;Qazi et al, 2007) and invasive (Saarakkala et al, 2003;Hattori et al, 2004;Kleemann et al, 2005) (Stolz, 2009). This study was based on biopsies, using a desk-top commercial atomic force microscope (AFM).…”