Feasibility of high-resolution one-dimensional relaxation imaging at low magnetic field using a single-sided NMR scanner applied to articular cartilage

Rößler, Erik; Mattea, Carlos; Stapf, Siegfried

doi:10.1016/j.jmr.2014.10.014

Cited by 24 publications

(22 citation statements)

References 29 publications

(33 reference statements)

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“…To relate the observed T 1 components to the constituents of cartilage, we recapitulated the results of the spatially resolved measurements of T 1 by Rössler et al carried out on a bulk sample of bovine articular cartilage. Thus, we plotted a histogram of the T 1 values from that study across the cartilages (Figure B), weighting their counts with the respective signal intensities and then overlaid it with our measurements (Figure ).…”

Section: Resultssupporting

confidence: 91%

“…From the slice‐selective low‐field relaxometry by Rössler et al, a single‐exponential‐fit parameter T 1 varies throughout the depth of AC over one order of magnitude. Our reproduction of a log‐binned histogram of T 1 (Figure B and Figure ) showed that it had a similar shape to the ILT T 1 distribution measured on the sum magnetization, even though it does not represent T 1 values on the order of the field‐switching time with correct weighting . On this basis, we have to ascribe a major effect to the zonal heterogeneity of AC.…”

Section: Discussionmentioning

confidence: 99%

“…A statistically significant difference was found between osteoarthritic and healthy cartilage for both the dispersion amplitude and the area of the QRE peaks, as well as for the maximum values of T 1 and T 2 when the samples were subject to external load . The power‐law exponent α in

T_{1} \sim B_{0}^{α}

at B 0 < 25 mT was found to correlate weakly with Mankin grade but significantly with other biomarkers . A number of parameters obtained at low magnetic field strengths were found to correlate with disease status only under external load …”

Section: Introductionmentioning

confidence: 99%

“…Nonexponential T 1 relaxation in AC can be anticipated from its zonal structure. Indeed, spatially resolved measurements of T 1 on bovine hip’s cartilage samples at B 0 = 0.27 T have shown that T 1 ranges between 30 ms in the calcified zone and 350 ms in the transitional zone, which is over 1 order of magnitude (Figure ). Therefore, one might expect a multiple T 1 relaxation for M tot ( t ) over the entire range of B 0 covered by a typical FFC instrument (B 0 ≤ 0.6 T), or at least below 0.27 T where this observation was made.…”

Section: Introductionmentioning

confidence: 99%

“…B, Spatially resolved measurements of T 1 relaxation times in the stray field of a single‐sided NMR scanner NMR MOUSE, at a Larmor frequency of 11.7 MHz (reprinted from Ref 5). In the original paper, single‐exponential fits were carried out per slice…”

Section: Introductionmentioning

confidence: 99%

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Multicomponent analysis of T₁ relaxation in bovine articular cartilage at low magnetic fields

Petrov

Stapf

2018

Magnetic Resonance in Med

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Purpose The multi‐exponential character of T 1 relaxation in bovine articular cartilage was investigated at low magnetic fields below 0.5 T. The ultimate aim was to identify a parameter based on the T 1 relaxation time distribution as a biomarker to biochemical features of osteoarthritis. Methods Osteoarthritis conditions were simulated by enzymatic digestion of cartilage with trypsin. Fast‐field cycling NMR relaxometry was carried out in the magnetic field range B 0 = 70 μT to 600 mT. The data were analyzed in terms of T 1 distributions on a log‐time scale using inverse Laplace transform, whereas integral properties such as mean T 1 s and distribution widths were obtained without data inversion from logarithmic moment analysis and a stretched‐exponential fit to the data. Attempts were also made to differentiate between water dynamic components through multi‐Lorentzian decomposition of average relaxation‐rate dispersions. Results T 1 distribution in bovine articular cartilage was found to be bimodal, with the dominating, long component shifting toward larger values following trypsin digestion. The effect is more prominent toward lower magnetic field strength. This shift leads to an overall increase of the distribution width and an equivalently more pronounced deviation from exponential behavior. Conclusion The logarithmic width of T 1 distribution functions at fields of 0.5 T and below, and the stretched‐exponential decay fit exponent β , show a significant trend after trypsin digestion of cartilage. These 2 parameters are suggested as possible biomarkers for osteoarthritis in humans and can be acquired entirely in vivo, with increasing significance for lower magnetic field strengths.

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Section: Resultssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

T_{1} \sim B_{0}^{α}

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multicomponent analysis of T₁ relaxation in bovine articular cartilage at low magnetic fields

Petrov

Stapf

2018

Magnetic Resonance in Med

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NMR mit Tischgeräten und deren Anwendungen von der Materialwissenschaft bis zur organischen Chemie

Blümich

Singh

2017

Angewandte Chemie

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Die NMR‐Spektroskopie ist eine unverzichtbare Analysemethode. Bis vor kurzem erforderten die Geräte viel Platz, waren teuer und schwer zu bedienen. Dies hat sich mit der Einführung kompakter NMR‐Spektrometer geändert, die sich für die Analyse kleiner Moleküle auf der Laborbank eignen. Solche Spektrometer sind mit Permanentmagneten für 1H‐NMR‐Frequenzen zwischen 40 und 80 MHz ausgestattet. Erst seit wenigen Jahren gibt es kleine Permanentmagnete mit homogenen Magnetfeldern für hochaufgelöste Spektroskopie. Tischgeräte mit inhomogenen Feldern werden schon seit 40 Jahren zur Charakterisierung von Lebensmitteln und Materialien über Relaxations‐ und Diffusionsmessungen genutzt. Ähnliche NMR‐Geräte messen diese Parameter im Streufeld außerhalb des Magneten. Sie werden zur Untersuchung von Bohrlochwänden in Ölquellen sowie für zerstörungsfreie Analysenverwendet. Der gegenwärtige Stand von NMR‐Spektroskopie, ‐Bildgebung und ‐Relaxometrie wird hier anhand repräsentativer Beispiele beschrieben.

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Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry

et al. 2018

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It was established through in vivo T 1 measurements at lowm agnetic fields that tumour cells displayp roton T 1 values that are markedly longer than those shown by healthy tissue.M oreover,i th as been found that the elongation of T 1 parallels the aggressiveness of the investigated tumour.The T 1 lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na + /K + ATPase transporters.I tf ollows that the intracellular water lifetime represents ah allmark of tumour cells that can be easily monitored by measuring T 1 at different magnetic field strengths ranging from 0.2 to 200 mT.Magnetic resonance imaging (MRI) has played ak ey role in the field of oncology over the last few decades.T he prominent role of MRI relies on its superb spatial and temporal resolution, and its diagnostic power basically arises from the differences in the longitudinal (T 1 )a nd transverse (T 2 )p roton relaxation times between healthy and pathological tissues.H owever, at the magnetic field strength of the currently available MRI scanners,changes in T 1 do not appear to be sensitive enough to report on the particular aspects of the tumour stage. [1] However,t here is widespread opinion that at low magnetic field strength, the marked increase in R 1 (= 1/T 1 )o bserved in biological tissues might be beneficial towards improving the MRI diagnostic potential in tumour phenotyping. [2] Herein, it is shown that the in vivo acquisition of 1/T 1 nuclear magnetic resonance dispersion (NMRD) profiles (from 0.2 to 200 mT) fully supports this expectation as the observed R 1 values at low magnetic fields (< 0.2 T) enable the clear discrimination between tumours characterised by different metastatic potentials.The1 / T 1 NMRD profiles were acquired on fast field cycling (FFC) relaxometers,w hich are able to switch the Figure 1. A) The FFC experiment:T he nuclear spin polarization is built up during the pre-polarization phase, at B p .R elaxation occurs during the evolution period (t)atB r ,t hen the NMR signal is detected at B d . The sequence is repeated,s taggering t each time. ForB r > 7MHz, the cycle starts in the absence of any polarization field. B) Photographs of the FFC-NMR relaxometer showing the introducedm odificationsfor the in vivo acquisition:a)the FFC magnet;b)the mouse holding system;c )the transmitter/receiver coil around the mouse'sl eg.

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Feasibility of high-resolution one-dimensional relaxation imaging at low magnetic field using a single-sided NMR scanner applied to articular cartilage

Cited by 24 publications

References 29 publications

Multicomponent analysis of T₁ relaxation in bovine articular cartilage at low magnetic fields

Multicomponent analysis of T₁ relaxation in bovine articular cartilage at low magnetic fields

NMR mit Tischgeräten und deren Anwendungen von der Materialwissenschaft bis zur organischen Chemie

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry

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Feasibility of high-resolution one-dimensional relaxation imaging at low magnetic field using a single-sided NMR scanner applied to articular cartilage

Cited by 24 publications

References 29 publications

Multicomponent analysis of T1 relaxation in bovine articular cartilage at low magnetic fields

Multicomponent analysis of T1 relaxation in bovine articular cartilage at low magnetic fields

NMR mit Tischgeräten und deren Anwendungen von der Materialwissenschaft bis zur organischen Chemie

Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field‐Cycling Relaxometry

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Multicomponent analysis of T₁ relaxation in bovine articular cartilage at low magnetic fields

Multicomponent analysis of T₁ relaxation in bovine articular cartilage at low magnetic fields