Separation of Fe from whole blood matrix for precise isotopic ratio measurements by MC-ICP-MS: a comparison of different approaches

Stenberg, Anna; Malinovsky, Dmitry; Rodushkin, Ilia; Andrén, Henrik; Pontér, Christer; Öhlander, Björn; Baxter, Douglas C.

doi:10.1039/b210482b

Cited by 42 publications

(43 citation statements)

References 19 publications

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“…9 They demonstrated that human blood samples had low Fe isotopic ratios (-1.0 to -1.6‰/amu) relative to a reference material produced from a natural ore sample (IRMM-014). Zhu et al 10 and Stenberg et al 12 also reported a natural stable isotopic fractionation of Fe in blood. This pioneering work revealed that the Fe isotopic composition of blood is different among individuals, and that an isotopic variation could be attributed to a difference in the uptake, or metabolic efficiencies.…”

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confidence: 99%

Isotopic Analysis of Fe in Human Red Blood Cells by Multiple Collector-ICP-Mass Spectrometry

et al. 2004

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confidence: 99%

Isotopic Analysis of Fe in Human Red Blood Cells by Multiple Collector-ICP-Mass Spectrometry

et al. 2004

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“…[1][2][3][4][5][6][7][8][9][10][11][12] While the mechanisms of isotopic fractionation are not yet well understood, biological activity appears to be particularly important for the cause of variations in isotopic composition. Zinc is one of the most important elements as a biological essential element to activate physiological functions of various enzymes; deficiency of this element leads to poor growth, dermatitis or impaired immune function.…”

Section: Introductionmentioning

confidence: 99%

Precise Zn Isotopic Ratio Measurements of Human Red Blood Cell and Hair Samples by Multiple Collector-ICP-Mass Spectrometry

et al. 2005

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“…Stenberg et al used an MC-ICPMS instrument operated at a higher mass resolution for Fe isotopic analysis in whole blood [31]. Several sample preparation procedures were compared and their utility evaluated.…”

Section: High Mass Resolutionmentioning

confidence: 99%

Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP?mass spectrometry

Vanhaecke

Moëns

2004

Analytical and Bioanalytical Chemistry

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For isotope ratio applications where an internal isotope ratio precision >0.05-0.1% relative standard deviation suffices, single-collector inductively coupled plasma mass spectrometry (ICPMS) is fit-for-purpose, but for detecting more subtle variations in the natural isotopic composition of a target element, only multi-collector ICPMS (MC-ICPMS) can compete with thermal ionization mass spectrometry (TIMS). While as a result of the extensive sample preparation (analyte isolation) preceding TIMS and the "softer" ionization in vacuum, spectral interferences only seldom occur with this technique, their occurrence is recognized to be the most important drawback of ICPMS. This paper discusses high mass resolution and chemical resolution in a collision or dynamic reaction cell as powerful and versatile means to overcome spectral overlap and illustrates how their introduction has led to a substantial extension of the application range of ICPMS for isotope ratio applications. High mass resolution is the most elegant and straightforward way to overcome the problem of spectral overlap. Offering the possibility to operate the mass analyzer at a higher mass resolution, while at the same time preserving the flat-topped or trapezoidal peak shape required for highly precise isotope ratio measurements, was a challenge for the manufacturers of MC-ICPMS instrumentation. It will be discussed how these apparently contradicting requirements could be fulfilled simultaneously and an overview of the current situation will be given. Chemical resolution in a collision or dynamic reaction cell is an alternative to high mass resolution for overcoming spectral overlap. Real-life examples will be given to illustrate how also this approach can be used to advantage in isotope ratio work. Despite the greater flexibility and straightforwardness of high mass resolution, some situations will be discussed where chemical resolution is to be preferred. Finally, some desires as to future instrumentation are formulated.

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Separation of Fe from whole blood matrix for precise isotopic ratio measurements by MC-ICP-MS: a comparison of different approaches

Cited by 42 publications

References 19 publications

Isotopic Analysis of Fe in Human Red Blood Cells by Multiple Collector-ICP-Mass Spectrometry

Isotopic Analysis of Fe in Human Red Blood Cells by Multiple Collector-ICP-Mass Spectrometry

Precise Zn Isotopic Ratio Measurements of Human Red Blood Cell and Hair Samples by Multiple Collector-ICP-Mass Spectrometry

Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP?mass spectrometry

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