Separation of enantiomers of drugs by capillary electrophoresis I. γ-cyclodextrin as chiral solvating agent

This review gives a survey of different chiral separation principles and their use in high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques. The mechanisms of the different separation principles are briefly discussed and some selected applications are shown.

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“…A systematic screening of drugs comparing a-CD [348], b-CD [349], g-CD [350] and neutral CDderivatives [341] was done by Koppenhoefer et al…”

Section: Neutral CD Derivatives a Great Variety Of Neutral Derivativmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

225

135

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“…17 The higher concentration of 45 mmol/l ␥-CD applied in the present investigation on 86 drugs proved more successful. In fact, 13 racemates that had not been separated at the lower CSA concentration were now split into the enantiomers.…”

Section: Resultsmentioning

confidence: 85%

“…The three closely related structures (Fig. 3) allow the identification of systematic changes in the electrophoretic behaviour, dependent on the ring size of the cyclodextrin added (see Table 3; some of these data were reported previously 23,24 ). The cavity diameter is known as 5.7, 7.8, and 9.5 Å for ␣-, ␤-, and ␥-cyclodextrin, respectively.…”

Section: Resultsmentioning

confidence: 95%

Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma‐cyclodextrin as chiral solvating agent

et al. 1998

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“…The optical purity control was elaborated for 5,6-dihydro-2-aminotetralin [64], acetylcysteine [183], for the basic drugs denopamine, timepidium and trimetoquinol [184], for the chiral reagent 1-(9-fluorenyl)ethyl chloroformate [185] and for N-propionyl-6,7-dimethoxy-2-aminotetralin [186]. Procedures based on cyclodextrins as chiral selectors [31,187,188] were proposed for the drug screening.…”

Section: Practical Applicationsmentioning

confidence: 99%

Chiral separations in capillary electrophoresis

Vespalec

Boček

1999

Electrophoresis

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Separation of enantiomers of drugs by capillary electrophoresis I. γ-cyclodextrin as chiral solvating agent

Cited by 50 publications

References 18 publications

Chiral separation by chromatographic and electromigration techniques. A Review

Chiral separation by chromatographic and electromigration techniques. A Review

Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma‐cyclodextrin as chiral solvating agent

Chiral separations in capillary electrophoresis

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