Separation of drugs by packed-column supercritical fluid chromatography

Yaku, Koji; Morishita, Fujio

doi:10.1016/s0165-022x(00)00086-5

Cited by 31 publications

(16 citation statements)

References 44 publications

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“…Whatley [306] reported the separation of glibenclamide on cellulose-and amylose-based phases on a preparative scale. Yaku and Morishita [307] compared different cellulose-based CSPs for their ability to resolve dilthiazem enantiomers.…”

Section: Polysaccharide-based Phasesmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

225

135

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This review gives a survey of different chiral separation principles and their use in high-performance liquid chromatography (HPLC), gas chromatography (GC), supercritical fluid chromatography (SFC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques. The mechanisms of the different separation principles are briefly discussed and some selected applications are shown.

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Section: Polysaccharide-based Phasesmentioning

confidence: 99%

Chiral separation by chromatographic and electromigration techniques. A Review

Gübitz

Schmid

2001

Biopharm & Drug Disp

225

135

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“…Amongst them, electrophoretic techniques, like capillary electrophoresis (CE) [3][4][5][6][7], and chromatographic ones, like high-performance liquid chromatography (HPLC) [8][9][10][11][12] and supercritical-fluid chromatography (SFC) [13,14], proved to be very useful. In the pharmaceutical industry, the time-is-money policy requires fast method development.…”

Section: Introductionmentioning

confidence: 99%

Enantioseparations of basic and bifunctional pharmaceuticals by capillary electrochromatography using polysaccharide stationary phases

et al. 2003

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A fast screening strategy was developed in capillary electrochromatography (CEC) for the chiral separation of basic and bifunctional compounds. The screening conditions were determined on polysaccharide chiral stationary phases using 15 pharmaceutical compounds. The content and type of organic modifier, as well as the pH of the mobile phase appeared to have the largest influence on the chiral resolution. It was seen that for acidic compounds, our approach was not suitable. A generic mobile phase for basic and bifunctional compounds was determined. The testing on 20 additional compounds showed that the proposed mobile phase performed well since enantioselectivity was observed for 86% of the investigated compounds. A comparison of CEC and reversed-phase liquid chromatography (RPLC) results was attempted to demonstrate the potential of the used technique for chiral method development.

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“…Despite the apparent advantages of pairing pSFC with MS/MS, very few bioanalytical methods have been developed. This was partly due to the low availability of quality equipment [10]. After using one Jasco PU-1580-CO 2 pump for nearly a year in method development work on pSFC bioanalysis applications, the pump began to cavitate on an irregular basis.…”

Section: Chromatographic Systemmentioning

confidence: 99%