Separation of actinides at ultra-trace level from urine matrix using extraction chromatography-inductively coupled plasma mass spectrometry

Hang, Wei; Zhu, Luwang Andy; Zhong, Wenwan; Mahan, C.

doi:10.1039/b400598h

Cited by 54 publications

(29 citation statements)

References 30 publications

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“…On-line extraction chromatographic separation of actinides, including 241 Am, from urine matrices coupled with ICP-QMS has also been evaluated (Hang et al, 2004). 308 Detection limits of 0.15 pg mL À1 (0.02 Bq mL À1 ) were reported for a 25 mL urine sample volume. Coupling of ow injection analysis with ICP-SFMS has also been reported for the analysis of environmental samples, with detection limits down to 0.6 fg being reported.…”

Section: Americium-241mentioning

confidence: 99%

Plasma source mass spectrometry for radioactive waste characterisation in support of nuclear decommissioning: a review

Croudace

Russell

Warwick

2017

J. Anal. At. Spectrom.

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Section: Americium-241mentioning

confidence: 99%

Plasma source mass spectrometry for radioactive waste characterisation in support of nuclear decommissioning: a review

Croudace

Russell

Warwick

2017

J. Anal. At. Spectrom.

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“…ICPMS is a popular mass spectrometric technique to determine concentrations and isotope ratios of Am and other actinide elements (Agarande et al, ; Truscott et al, ; Boulyga et al, ; Lee et al, ; Hang et al, ; Pointurier, Baglan, & Hemet, ; Wang, Chen, & Chiu, ; Epov et al, ; Lee et al, ; Varga, ; Varga et al, ,; Zheng & Yamada, ; Guerin et al, ; Krachler et al, ). In ICP, the M + ions are produced with generation of plasma (with Ar gas) at atmospheric pressure, and introduction of the sample into the spray chamber with a pneumatic nebulizer.…”

Section: Different Mass Spectrometric Techniques Used For Am and Its mentioning

confidence: 99%

“…241 Am along with other actinides (Np, U, Pu, and Th) was determined in urine samples, for bioassay, with on‐line coupling the extraction chromatography column to a Q‐ICPMS (Hang et al, ). The TRU extractant resin, which consists of carbamoylmethylphosphine oxide (CMPO) dissolved in tri‐n‐butyl phosphate (TBP), was used as a stationary phase.…”

Section: Applications Of Various Mass Spectrometric Techniques For Stmentioning

confidence: 99%

A review on the mass spectrometric studies of americium: Present status and future perspective

Aggarwal

2016

Mass Spectrometry Reviews

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The manuscript reviews the various mass spectrometric techniques for analysis and chemical studies of Americium. These methods include thermal ionization mass spectrometry (TIMS), and inductively coupled plasma source mass spectrometry (ICPMS) for the determination of Am isotope ratios and concentration in nuclear fuel samples of interest in nuclear technology, and in complex biological and environmental samples. Ultra-sensitive mass spectrometric techniques of resonance-ionization mass spectrometry (RIMS), and accelerator-based mass spectrometry (AMS) are also discussed. The novel applications of electrospray ionization mass spectrometry (ESIMS) to understand the solution chemistry of Am and other actinides are presented. These studies are important in view of the world-wide efforts to develop novel complexing agents to separate lanthanides and minor actinides (Am, Np, and Cm) for partitioning and transmutation of minor actinides from the point of view of nuclear waste management. These mass spectrometry experiments are also of great interest to examine the covalent character of actinides with increasing atomic number. Studies on gas-phase chemistry of Am and its oxides with Knudsen effusion mass spectrometry (KEMS), Fourier-transform ion cyclotron resonance mass spectrometry (FTICR-MS), and laser-based experiments with reflectron time-of-flight mass spectrometer (R-ToF) are highlighted. These studies are important to understand the fundamental chemistry of 5f electrons in actinides. Requirement of certified isotopic reference materials of Am to improve the accuracy of experimental nuclear data (e.g., the half-life of Am) is emphasized. © 2016 Wiley Periodicals, Inc. Mass Spec Rev.

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“…Hang et al using TRU Resin to separate actinides, but this work lacked the selectivity needed to measure actinides at ultra trace levels in urine, due to overlapping of actinide peaks [6] . Epov at al reported an automated preconcentration system using TRU Resin, but indicated that the separation of uranium 4 from plutonium was not complete [7] .…”

Section: Introductionmentioning

confidence: 99%

Rapid determination of actinides in urine by inductively coupled plasma mass spectrometry and alpha spectrometry: A hybrid approach

Maxwell

Jones

2009

Talanta

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A new rapid separation method that allows separation and preconcentration of actinides in urine samples was developed for the measurement of longer-lived actinides by inductively-coupled plasma mass spectrometry (ICP-MS) and short-lived actinides by alpha spectrometry; a hybrid approach. This method uses stacked extraction chromatography cartridges and vacuum box technology to facilitate rapid separations. Preconcentration, if 2 required, is performed using a streamlined calcium phosphate precipitation. Similar technology has been applied to separate actinides prior to measurement by alpha spectrometry, but this new method has been developed with elution reagents now compatible with ICP-MS as well. Purified solutions are split between ICP-MS and alpha spectrometry so that long and short-lived actinide isotopes can be measured successfully. The method allows for simultaneous extraction of 24 samples in less than 3 hours (<7.5 minutes per sample).The simplicity and speed of this new method makes it attractive for radiological emergency response. If preconcentration is applied, the method is applicable to larger sample aliquots for occupational exposures as well. The chemical recoveries are typically greater than 90%, in contrast to other reported methods using flow injection separation techniques where plutonium yields were 70-80%. This method allows measurement of both long-lived and short-lived actinide isotopes. 239 Am, 243 Am and 244 Cm were measured by alpha spectrometry. The method can also be adapted so that the separation of uranium isotopes for assay is not required, if uranium assay by direct dilution of the urine sample is preferred instead. Multiple vacuum box locations may be set-up to supply several ICP-MS units with purified sample fractions such that a high sample throughput may be achieved, while still allowing for rapid measurement of short-lived actinides by alpha spectrometry.

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Separation of actinides at ultra-trace level from urine matrix using extraction chromatography-inductively coupled plasma mass spectrometry

Cited by 54 publications

References 30 publications

Plasma source mass spectrometry for radioactive waste characterisation in support of nuclear decommissioning: a review

Plasma source mass spectrometry for radioactive waste characterisation in support of nuclear decommissioning: a review

A review on the mass spectrometric studies of americium: Present status and future perspective

Rapid determination of actinides in urine by inductively coupled plasma mass spectrometry and alpha spectrometry: A hybrid approach

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