Separation of 3′-sialyllactose and lactose by nanofiltration: A trade-off between charge repulsion and pore swelling induced by high pH

Nordvang, Rune Thorbjørn; Luo, Jianquan; Zeuner, Birgitte; Prior, Rasmus; Andersen, Mads Friis; Mikkelsen, Jørn Dalgaard; Meyer, Anne S.; Pinelo, Manuel

doi:10.1016/j.seppur.2014.10.012

Cited by 22 publications

(13 citation statements)

References 26 publications

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“…Further amounts of diafiltration (up to 10 volumes) were conducted with minimal improvement. In a study investigating oligosaccharide purification, similar results were observed by other researchers in a small-scale, dead-end filtration experiment using a model solution of lactose and sialyllactose, where lactose recovery in the retentate was nearly zero after approximately seven rounds of diafiltration (Nordvang et al, 2014). The removal of monosaccharides and other dissolved solids with discontinuous diafiltration reduced the density of the retentate from 1.074 g mL −1 to 1.032 g mL −1 , being equivalent to a decrease in total solids from 17.2% in the retentate before diafiltration to 8.9% after ten discontinuous diafiltration steps.…”

Section: Resultssupporting

confidence: 73%

“…Enzymatic hydrolysis of lactose into glucose and galactose prior to NF can improve efficiency and selectivity of membrane-based separations (Goulas, Kapasakalidis, Sinclair, Rastall, & Grandison, 2002). Recent investigations focused on improving the separation of oligosaccharides from monosaccharides at a variety of scales reported low selectivity using membrane filtration (Altmann et al, 2015; Martinez-Ferez et al, 2006; Nordvang et al, 2014). Generally, it has been found that critical operational parameters affecting membrane selectivity and performance include membrane chemistry, molecular-weight cutoff, transmembrane pressure (TMP), pH and solute concentration of the feed, and the use of diafiltration.…”

Section: Introductionmentioning

confidence: 99%

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Role of pH in the recovery of bovine milk oligosaccharides from colostrum whey permeate by nanofiltration

Cohen

Barile

Liu

et al. 2017

International Dairy Journal

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Milk oligosaccharides are associated with improved health outcomes in infants. Nanofiltration (NF) is used for isolation of bovine milk oligosaccharides (BMO). The study aim was to improve the recovery of BMO from lactose-hydrolyzed colostrum whey permeate. The retention factors of carbohydrates at various pH and transmembrane pressures were determined for a nanofiltration membrane, which was used at pilot scale to purify BMO. Carbohydrates were quantified by liquid chromatography and characterized using nano-LC-Chip-QToF mass spectrometry. BMO purity was improved from an initial 4% in colostrum whey permeate to 98%, with 99.8% permeation of monosaccharides and 96% recovery of oligosaccharides, represented by 23 unique BMO compounds identified in the final retentate. The pH during NF was a determining factor in the selectivity of carbohydrate separation. This NF method can be applied to conventional cheese-whey permeate and other milk types for extraction of bioactive oligosaccharides providing new options for the dairy industry.

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Section: Resultssupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Role of pH in the recovery of bovine milk oligosaccharides from colostrum whey permeate by nanofiltration

Cohen

Barile

Liu

et al. 2017

International Dairy Journal

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“…Thereby, the pH value of the solution plays a significant role in removing charged drugs by NF. Some studies have reported that the role of electrostatic repulsion is very crucial in removing the charged organic solutes [20][21][22][27][28][29]. Based on our literature survey, the role of steric exclusion for removal the charged organic solutes is still not clear.…”

Section: Introductionmentioning

confidence: 85%

“…The surface chemical characteristics of NF membrane are determined by the polyamide layer. This polyamide layer contains both carboxylic and amine functional groups that can ionize in the aqueous solution [27]. The degree that NF membrane surface has been negatively charged can be clearly reflected and characterized by using the rejection rates of sodium chloride at the different pH values shown in Fig.…”

Section: Removal Mechanisms Of Negatively Charged Drugs By Nf Membranementioning

confidence: 99%

“…The previous research showed that most of NF membranes were negatively charged at the condition of neutral or alkaline solution due to the dissociation of functional groups (e.g., carboxylic acid groups) on the membrane surface [27]. The amount of negative charges on membrane surface increases with the increase of the pH value of the solution due to the acid group on membrane surface is gradually dissociated.…”

Section: Introductionmentioning

confidence: 99%

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Rejection rate and mechanisms of drugs in drinking water by nanofiltration technology

Feng

Zhang

et al. 2017

Environmental Engineering Research

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Nanofiltration (NF) technology is a membrane-based separation process, which has been pervasively used as the high-effective technology for drinking water treatment. In this study, a kind of composite polyamide NF thin film is selected to investigate the removal efficiencies and mechanisms of 14 trace drugs, which are commonly and frequently detected in the drinking water. The results show that the removal efficiencies of most drugs are quite high, indicating the NF is an effective technology to improve the quality of drinking water. The removal efficiencies of carbamazepine, acetaminophen, estradiol, antipyrine and isopropyl-antipyrine in ultrapure water are 78.8 ± 0.8%, 16.4 ± 0.5%, 65.4 ± 1.8%, 71.1 ± 1.5% and 89.8 ± 0.38%, respectively. Their rejection rates increase with the increasing of their three-dimensional sizes, which indicates that the steric exclusion plays a significant role in removal of these five drugs. The adsorption of estradiol with the strongest hydrophobicity has been studied, which indicates that adsorption is not negligible in terms of removing this kind of hydrophobic neutral drugs by NF technology. The removal efficiencies of indomethacin, diclofenac, naproxen, ketoprofen, ibuprofen, clofibric acid, sulfamethoxazole, amoxicillin and bezafibrate in ultrapure water are 81 ± 0.3%, 86.3 ± 0.5%, 85.7 ± 0.4%, 93.3 ± 0.3%, 86.6 ± 2.5%, 90.6 ± 0.4%, 59.7 ± 1.7%, 80.3 ± 1.4% and 80 ± 0.5%, respectively. For these nine drugs, their rejection rates are better than the above five drugs because they are negatively charged in ultrapure water. Meanwhile, the membrane surface presents the negative charge. Therefore, both electrostatic repulsion and steric exclusion are indispensable in removing these negatively charged drugs. This study provides helpful and scientific support of a highly effective water treatment method for removing drugs pollutants from drinking water.

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Synthesis and purification of galacto-oligosaccharides: state of the art

Vera

Córdova

Aburto

et al. 2016

World J Microbiol Biotechnol

117

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Lactose-derived non-digestible oligosaccharides are prominent components of functional foods. Among them, galacto-oligosaccharides (GOS) outstand for being prebiotics whose health-promoting effects are supported on strong scientific evidences, having unique properties as substitutes of human milk oligosaccharides in formulas for newborns and infants. GOS are currently produced enzymatically in a kinetically-controlled reaction of lactose transgalactosylation catalyzed by β-galactosidases from different microbial strains. The enzymatic synthesis of GOS, although being an established technology, still offers many technological challenges and opportunities for further development that has to be considered within the framework of functional foods which is the most rapidly expanding market within the food sector. This paper presents the current technological status of GOS production, its main achievements and challenges. Most of the problems yet to be solved refer to the rather low GOS yields attainable that rarely exceed 40 %, corresponding to lactose conversions around 60 %. This means that the product or reaction (raw GOS) contains significant amounts of residual lactose and monosaccharides (glucose and galactose). Efforts to increase such yields have been for the most part unsuccessful, even though improvements by genetic and protein engineering strategies are to be expected in the near future. Low yields impose a burden on downstream processing to obtain a GOS product of the required purity. Different strategies for raw GOS purification are reviewed and their technological significance is appraised.

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Separation of 3′-sialyllactose and lactose by nanofiltration: A trade-off between charge repulsion and pore swelling induced by high pH

Cited by 22 publications

References 26 publications

Role of pH in the recovery of bovine milk oligosaccharides from colostrum whey permeate by nanofiltration

Role of pH in the recovery of bovine milk oligosaccharides from colostrum whey permeate by nanofiltration

Rejection rate and mechanisms of drugs in drinking water by nanofiltration technology

Synthesis and purification of galacto-oligosaccharides: state of the art

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