Separation of 2-Bromobutane, 2-Chlorobutane, 2-Chloropentane, and 2-Butanol Enantiomers Using a Stationary Phase Based on a Supramolecular Uracil Structure

Nafikova, Aigul; Allayarova, D. A.; Gus’kov, V. Yu.

doi:10.1134/s1061934819060078

Cited by 5 publications

(1 citation statement)

References 31 publications

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“…This layer can be used for the separation of 2-butanol, 2-bromobutane, and other substances by GC, in which the cyclization selectivity is the result of the removal of the central molecule of the supramolecular structure at 200 °C. Similarly, in 2019, Nafikova et al [ 75 ] investigated a uracil structure as a stationary phase and successfully separated the enantiomers of several substances. In the temperature range studied, the enantiomers of 2-bromobutane and 2-chlorobutane were completely separated at 45 °C in 210 and 180 s, and the enantiomers of 2-chlorobutane were separated at 60 °C in 160 s. Guskov et al [ 74 ] used indirect methods of static adsorption with polarization control and GC to differentially adsorb enantiomers on modified adsorbents, demonstrating the usefulness of chiral recognition scaffolds ( Figure 4 c).…”

Section: Chromatographic Separationmentioning

confidence: 99%

Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

et al. 2021

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With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.

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Section: Chromatographic Separationmentioning

confidence: 99%