Separation methods for antibacterial and antirheumatism agents in plant medicines

Wen, Dawei; Liu, Yuping; Li, Wei; Liu, Huwei

doi:10.1016/j.jchromb.2004.06.049

Cited by 20 publications

(13 citation statements)

References 117 publications

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“…However, the core chemical classes of anti-inflammatory agents from natural sources have been usually reported to engage a vast range of compounds such as polyphenolics, flavonoids, terpenoids, alkaloids, anthraquinones, lignans, polysaccharides, saponins and peptides (Sparg et al, 2004;Wen et al, 2004). Amongst them, alkaloids in assorted skeletal types based on pyridine ring system have been presented with striking anti-inflammatory activity.…”

Section: Resultsmentioning

confidence: 99%

Appraisal of anti-inflammatory potential of the clubmoss, Lycopodium clavatum L.

Orhan

Küpeli

Şener

et al. 2007

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

Appraisal of anti-inflammatory potential of the clubmoss, Lycopodium clavatum L.

Orhan

Küpeli

Şener

et al. 2007

Journal of Ethnopharmacology

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“…The focus on the development of bacteriostatic or bactericidal therapies is not surprising as dental caries is an infectious disease and there is an established and successful history of discovery of novel antibiotics as a result of natural product screening. Most of these compounds are derived from secondary metabolites of plant origin, including phenolic acids, anthraquinones, flavonoids, stilbenes, tannins, terpenoids and alkaloids, all of which are effective inhibitors of the growth of other pathogenic microorganisms [Wen et al, 2004]. Compounds targeting bacterial viability are typically aiming at bacterial eradication via one or more of the following modalities [Cowan, 1999]: (i) disruption of cell wall biosynthesis and/or cell membrane permeability, (ii) complexing with surface-adsorbed components, (iii) inhibiting protein synthesis or nucleic acid metabolism, and/or (iv) inhibition of enzyme activity through oxidation of other, often uncharacterized, interactions with bacterial proteins.…”

Section: Influence Of Natural Products On the Pathophysiology Of Dentmentioning

confidence: 99%

Natural Products in Caries Research: Current (Limited) Knowledge, Challenges and Future Perspective

et al. 2011

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Dental caries is the most prevalent and costly oral infectious disease worldwide. Virulent biofilms firmly attached to tooth surfaces are prime biological factors associated with this disease. The formation of an exopolysaccharide-rich biofilm matrix, acidification of the milieu and persistent low pH at the tooth-biofilm interface are major controlling virulence factors that modulate dental caries pathogenesis. Each one offers a selective therapeutic target for prevention. Although fluoride, delivered in various modalities, remains the mainstay for the prevention of caries, additional approaches are required to enhance its effectiveness. Available antiplaque approaches are based on the use of broad-spectrum microbicidal agents, e.g. chlorhexidine. Natural products offer a rich source of structurally diverse substances with a wide range of biological activities, which could be useful for the development of alternative or adjunctive anticaries therapies. However, it is a challenging approach owing to complex chemistry and isolation procedures to derive active compounds from natural products. Furthermore, most of the studies have been focused on the general inhibitory effects on glucan synthesis as well as on bacterial metabolism and growth, often employing methods that do not address the pathophysiological aspects of the disease (e.g. bacteria in biofilms) and the length of exposure/retention in the mouth. Thus, the true value of natural products in caries prevention and/or their exact mechanisms of action remain largely unknown. Nevertheless, natural substances potentially active against virulent properties of cariogenic organisms have been identified. This review focuses on gaps in the current knowledge and presents a model for investigating the use of natural products in anticaries chemotherapy.

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“…[111213] XDT is composed of seven medicinal herbs: Inulae Flos(xuanfuhua); Haematitum(daizheshi); Ginseng Radix Et Rhizoma(renshen); Glycyrrhizae Radix Et Rhizoma(gancao); Pinelliae Rhizoma Praeparatum(fabanxia); Jujubae Fructus(dazao) and Zingiberis Rhizoma(shengjiang). Chemical and pharmacological studies have shown that chlorogenic acid from Inulae Flos ,[14] ginsenosides including ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Re from Ginseng Radix Et Rhizoma ,[1516] and glycyrrhizic acid from Glycyrrhizae Radix Et Rhizoma ,[1718] are considered to be the active compounds in XDT. These components are usually regarded as the markers of quality control and evaluation only by consideration of their actions, contents and suitable UV absorptions.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of five marker compounds in Xuanfu Daizhe Tang by high-performance liquid chromatography coupled with diode array detection for quality control

et al. 2012

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Background:Xuanfu Daizhe Tang (XDT) is a classical traditional Chinese medicinal prescription that has been widely used for treating digestive system illnesses for hundreds of years.Materials and Methods:In this study, a simple and sensitive high-performance liquid chromatography coupled with diode array detection (HPLC-DAD) method was established for the simultaneous determination of five marker compounds in XDT including chlorogenic acid, glycyrrhizic acid, ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Re, for quality control of this well-known traditional Chinese medicine (TCM).Results:These compounds were separated in less than 130 min using a YMC C18 column with a gradient elution system of acetonitrile and 0.1% phosphoric acid water solution at a flow rate of 1 ml/min. All calibration curves of standard components showed good linearity with R2 >0.9991. Limit of detection and limit of quantification varied from 0.11 to 4.3 μg/ml and 0.20 to 11.6 μg/ml, respectively. The relative standard deviations (RSDs) of the intra-day and inter-day experiments were less than 4.72 and 5.48%, respectively. The accuracy of recovery test ranged from 95.0 to 105.0% with RSD values 1.28- 4.32%.Conclusion:The validated method is simple, reliable, and successfully applied to determine the contents of the selected compounds in XDT for quality control.

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Separation methods for antibacterial and antirheumatism agents in plant medicines

Cited by 20 publications

References 117 publications

Appraisal of anti-inflammatory potential of the clubmoss, Lycopodium clavatum L.

Appraisal of anti-inflammatory potential of the clubmoss, Lycopodium clavatum L.

Natural Products in Caries Research: Current (Limited) Knowledge, Challenges and Future Perspective

Simultaneous determination of five marker compounds in Xuanfu Daizhe Tang by high-performance liquid chromatography coupled with diode array detection for quality control

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