Separation, enrichment and determination of ciprofloxacin using thermoseparating polymer aqueous two-phase system combined with high performance liquid chromatography in milk, egg, and shrimp samples

Chen, Bo; Han, Juan; Wang, Yun; Sheng, Chengzhuo; Liu, Yu; Zhang, Guocai; Yan, Yongsheng

doi:10.1016/j.foodchem.2013.10.011

Cited by 57 publications

(23 citation statements)

References 18 publications

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“…With this property, the phase-forming EOPO in ATPS could be effectively recycled and separated from the target product by heating (Show et al, 2011). Therefore, EOPO has been widely applied in ATPE, such as extraction of lipase (Show et al, 2011) and enrichment of ciprofloxacin (Chen et al, 2014). In recent years, a new thermosensitive polymer which named ethylene oxide-b-propylene oxide-bethylene oxide (EOPOEO) triblock copolymer has been applied in ATPE (De Oliveira, de Abreu Filho, & de Alcântara Pessôa Filho, 2007;Rabelo, Tambourgi, & Pessoa, 2004).…”

Section: Introductionmentioning

confidence: 99%

Integrated method of thermosensitive triblock copolymer–salt aqueous two phase extraction and dialysis membrane separation for purification of lycium barbarum polysaccharide

Wang

Han

et al. 2016

Food Chemistry

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Section: Introductionmentioning

confidence: 99%

Integrated method of thermosensitive triblock copolymer–salt aqueous two phase extraction and dialysis membrane separation for purification of lycium barbarum polysaccharide

Wang

Han

et al. 2016

Food Chemistry

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“…In addition, this method reduces errors associated with the collection of extraction media, with solidified fatty acids providing a highly efficient extraction agent to further improve extraction recovery [35]. Sample preparation time (23.9 min) was much shorter than SPE (150 h, 22 h, and 260 min) [11,22,23], SPME (55 min) [46], and TPATPS (14 h) [51]. SPE and SPME require intensive washing of the extraction column with organic solvent [11,22] or a long vortex time (~22 h) [23] to improve extraction recovery, whereas ATPS requires 2 h to form the aqueous two-phase system and 12 h to separate the extraction solution and extraction solvent.…”

Section: Comparison Of the Ea-sfam-sfo Methods With Othersmentioning

confidence: 99%

An effervescence-assisted switchable fatty acid-based microextraction with solidification of floating organic droplet for determination of fluoroquinolones and tetracyclines in seawater, sediment, and seafood

et al. 2018

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This study developed a new effervescence-assisted switchable fatty acid-based microextraction combined with solidification of a floating organic-droplet (EA-SFAM-SFO) for simple and rapid determination of fluoroquinolones and tetracyclines in seawater, sediment, and seafood. Five medium-chain fatty acids (pentanoic acid, hexanoic acid, heptanoic acid, octanoic acid, and nonanoic acid) were tested as an extraction solvent, given their ability to change between hydrophobic and hydrophilic forms by pH adjustment. As nonanoic acid had the highest extraction recovery (>92%) for the six antibiotics and the ability to transform from liquid to a solidified floating state at low temperature, it was selected as the optimum extraction solvent. The prominent advantages of the newly developed method are: (1) reaction between the procedures salt and fatty acid changed extraction solvent from the hydrophobic to hydrophilic state; (2) bubbling with CO greatly increased the contact area between fatty acid and analytes resulting in improved extraction recovery; and (3) solidification of the fatty acid at a low temperature provided good separation and avoided the use of specialized equipment. Single-factor screening and optimization of the main factors were conducted using Plackett-Burman design and central composite design, respectively. The main parameters were optimized as follows: 258 μL fatty acid, 406 μL HSO (98%), 3.9 min vortex time, and 354 μL NaCO (2 mol L1). Under optimized conditions, limits of detection were 0.007-0.113 μg L or μg kg and extraction recoveries were 82.2%-116.7% for six fluoroquinolone and tetracycline antibiotics in seawater, sediments, and seafood. The newly developed method combines the advantages of effervescence-assisted dispersion, hydrophobic/hydrophilic switchable solvent, and liquid/solid transition induced by low temperature. Overall, the new method is simple, quick, and environment-friendly with low detection limits and high recoveries. Thus, the newly developed method has excellent prospects for sample pretreatment and analysis of antibiotics in marine environmental and food samples. Graphical Abstract ᅟ.

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“…A series of analytical methods have been reported for the determination of CF including spectrophotometry, mass spectrophotometry, liquid chromatography, high performance liquid chromatography, capillary electrophoresis, and electrochemical techniques [6][7][8][9][10][11][12]. The free concentration is generally believed to be responsible for the toxic effects and bioavailable for organisms [13].…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer based diffusive gradients in thin‐films for in situ selective sampling and determination of ciprofloxacin

Chen

Zhu

et al. 2018

J of Separation Science

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A technique of diffusive gradients in thin films with ciprofloxacin-molecularly imprinted polymers as the binding agent was developed for in situ selective sampling and measurement of ciprofloxacin in water. The ciprofloxacin uptake by the method increased linearly with time (r = 0.998) with a recovery of 96.8% in synthetic solution. The method performance was not dependent on solution pH over the pH range of 2-11 and ionic strength range from 1 × 10 to 0.5 mol/L sodium nitrate. The binding agent has a higher adsorption affinity for ciprofloxacin than for other drug residues, such as norfloxacin, chloramphenicol, and malachite green. The concentration of ciprofloxacin in river water determined by this method was 0.52 ± 0.3 μg/L, and the recoveries of ciprofloxacin were 96.1-102.0%.

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Separation, enrichment and determination of ciprofloxacin using thermoseparating polymer aqueous two-phase system combined with high performance liquid chromatography in milk, egg, and shrimp samples

Cited by 57 publications

References 18 publications

Integrated method of thermosensitive triblock copolymer–salt aqueous two phase extraction and dialysis membrane separation for purification of lycium barbarum polysaccharide

Integrated method of thermosensitive triblock copolymer–salt aqueous two phase extraction and dialysis membrane separation for purification of lycium barbarum polysaccharide

An effervescence-assisted switchable fatty acid-based microextraction with solidification of floating organic droplet for determination of fluoroquinolones and tetracyclines in seawater, sediment, and seafood

Molecularly imprinted polymer based diffusive gradients in thin‐films for in situ selective sampling and determination of ciprofloxacin

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