Molecularly imprinted polymer based diffusive gradients in thin‐films for in situ selective sampling and determination of ciprofloxacin

Abstract

A technique of diffusive gradients in thin films with ciprofloxacin-molecularly imprinted polymers as the binding agent was developed for in situ selective sampling and measurement of ciprofloxacin in water. The ciprofloxacin uptake by the method increased linearly with time (r = 0.998) with a recovery of 96.8% in synthetic solution. The method performance was not dependent on solution pH over the pH range of 2-11 and ionic strength range from 1 × 10 to 0.5 mol/L sodium nitrate. The binding agent has a higher adsorption affinity for ciprofloxacin than for other drug residues, such as norfloxacin, chloramphenicol, and malachite green. The concentration of ciprofloxacin in river water determined by this method was 0.52 ± 0.3 μg/L, and the recoveries of ciprofloxacin were 96.1-102.0%.

Co-precipitation polymerization of dual functional monomers and polystyrene-co-divinylbenzene for ciprofloxacin imprinted polymer preparation

“…The highly polar aprotic solvent (ACN) is suitable for preparing of CIP imprinted polymers. 19,24 In contrast, the polar protic solvent (methanol) reduces the imprinted polymer selectivity due to their competitive interaction with MAA via hydrogen bond. 19 Moreover, the MIPs synthesized in highly polar solvents have small particles (<2 mm) for SPE applications.…”

Biomimetic Accumulation of Methamphetamine and Its Metabolite Amphetamine by Diffusive Gradients in Thin Films to Estimate Their Bioavailability in Zebrafish

“…DGTs have been successfully applied to measure trace components in situ in aquatic environments, especially to monitor trace contaminants with high water solubility. − Since Chen et al applied DGT to detect the sulfonamide antibiotic in water in 2012, DGT has been gradually developed for the detection of various organic substances in aquatic environment. To date, DGT has been applied to detect pharmaceuticals, , antibiotics, estrogen, anionic pesticides, illicit drugs, , and organophosphate esters . Guo et al confirmed that DGTs can be used for in situ monitoring of several illicit drugs, including METH, in waste waters and rivers .…”

Investigating Potential Limitations of Current Diffusive Gradients in Thin Films (DGT) Samplers for Measuring Organic Chemicals

“…In contrast, research and development of DGT for organic chemicals only started in 2012, but it has already attracted considerable interest and is developing rapidly . To date, sampler development and testing of 136 organic compounds has been reported in the literature (a few from personal communication), with more being conducted. − Compound classes include pharmaceuticals and personal care products, illicit drugs, endocrine-disrupting chemicals and pesticides, etc. Table S1 summarizes these publications.…”