Separation, Characterization and Anticoagulant Activity of Coumarin and its Derivatives Extracted from Melilotus officinalis

Antagonists of Vitamin K—Popular Coumarin Drugs and New Synthetic and Natural Coumarin Derivatives

“…Three coumarin related compounds, i.e., hyuganin C (Figure 17, 46), isoepoxypteryxin, and isopterixin were isolated and hyuganin C had a moderate anticoagulant activity as well as a moderate antiplatelet activity against ADP-induced platelet aggregation [115]. An extract obtained from a Melilotus officinalis plant used in a volume of 25, 50, and 75 µL showed a dose dependent prothrombin time of treated blood of 46 s, 140 s, and no-clot effect, respectively [116]. The extract was fractionated by column chromatography and anticoagulant activity was assessed for nine fractions, in which several coumarins were identified as: dicoumarol (18 in Figure 8 In Artemisia dracunculus leaf extract (collected from the Sarajevo district) five coumarin derivatives were identified (Table 3) and anticoagulation tests were done, which showed their dose dependent activity [117].…”

Design and Synthesis of Novel C4‐Linked Substituted 2H‐Chromen‐2‐one‐hypoxanthine Hybrids as Potential Antimicrobial Agents: An Approach to Molecular Docking Studies

“…Coumarin compounds contributed an extended therapeutic outline with a wide range of biological activities, which are naturally plant‐derived or synthetically obtained substances . Almost all coumarin derivatives have been considered as the key subunits for different kinds of effective drug candidates in terms of their dynamic pharmacological activities such as anti‐inflammatory , antitubercular , anti‐human immunodeficiency virus , antioxidant , anticoagulant , anticancer , and antiviral . In addition, these derivatives are used as pharmaceuticals and optical brighteners , additives in foods and cosmetics , and laser dyes .…”