Separation and Identification of Cucurbitane-Type Triterpenoids from Bitter Melon

Pérez, José L.; Jayaprakasha, G.K.

doi:10.1021/bk-2014-1185.ch003

Cited by 9 publications

(2 citation statements)

References 82 publications

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“…The leaf, stem, root, and fruit of bitter melon contain β-carotene, a vitamin A precursor in the human body [9], and constitute an important market vegetable in tropical regions [3]. Vines, seeds, and fruit exocarp have health-promoting characteristics in traditional medicine [10]. Nowadays, bitter melon is in strong demand in ethnic markets, particularly in African, Asian, and South American countries.…”

Section: Introductionmentioning

confidence: 99%

In vitro Rapid Regeneration of Bitter Melon (Momordica charantia L.) Using Direct Organogenesis in Kenya

Naitchede¹,

Runo²,

Nyende³

2022

ujar

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Section: Introductionmentioning

confidence: 99%

In vitro Rapid Regeneration of Bitter Melon (Momordica charantia L.) Using Direct Organogenesis in Kenya

Naitchede¹,

Runo²,

Nyende³

2022

ujar

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“…HRESIMS of compound 6 showed a molecular ion at m / z 687.3967 [M + Na] + (calculated 687.4047 ± 0.008 m / z [M + Na] + for C 37 H 60 O 10 ). The molecular formula of compound 6 was compared with reported triterpenes isolated from M. charantia and our in-house database [ 20 ]. No match was observed, suggesting an unknown compound.…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory, Antidiabetic Properties and In Silico Modeling of Cucurbitane-Type Triterpene Glycosides from Fruits of an Indian Cultivar of Momordica charantia L.

et al. 2021

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Diabetes mellitus is a chronic disease and one of the fastest-growing health challenges of the last decades. Studies have shown that chronic low-grade inflammation and activation of the innate immune system are intimately involved in type 2 diabetes pathogenesis. Momordica charantia L. fruits are used in traditional medicine to manage diabetes. Herein, we report the purification of a new 23-O-β-d-allopyranosyl-5β,19-epoxycucurbitane-6,24-diene triterpene (charantoside XV, 6) along with 25ξ-isopropenylchole-5(6)-ene-3-O-β-d-glucopyranoside (1), karaviloside VI (2), karaviloside VIII (3), momordicoside L (4), momordicoside A (5) and kuguaglycoside C (7) from an Indian cultivar of Momordica charantia. At 50 µM compounds, 2-6 differentially affected the expression of pro-inflammatory markers IL-6, TNF-α, and iNOS, and mitochondrial marker COX-2. Compounds tested for the inhibition of α-amylase and α-glucosidase enzymes at 0.87 mM and 1.33 mM, respectively. Compounds showed similar α-amylase inhibitory activity than acarbose (0.13 mM) of control (68.0-76.6%). Karaviloside VIII (56.5%) was the most active compound in the α-glucosidase assay, followed by karaviloside VI (40.3%), while momordicoside L (23.7%), A (33.5%), and charantoside XV (23.9%) were the least active compounds. To better understand the mode of binding of cucurbitane-triterpenes to these enzymes, in silico docking of the isolated compounds was evaluated with α-amylase and α-glucosidase.

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Evaluation of bitter melon (Momordica charantia) cultivars grown in Texas and levels of various phytonutrients

et al. 2018

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Separation and Identification of Cucurbitane-Type Triterpenoids from Bitter Melon

Cited by 9 publications

References 82 publications

In vitro Rapid Regeneration of Bitter Melon (Momordica charantia L.) Using Direct Organogenesis in Kenya

In vitro Rapid Regeneration of Bitter Melon (Momordica charantia L.) Using Direct Organogenesis in Kenya

Anti-Inflammatory, Antidiabetic Properties and In Silico Modeling of Cucurbitane-Type Triterpene Glycosides from Fruits of an Indian Cultivar of Momordica charantia L.

Evaluation of bitter melon (Momordica charantia) cultivars grown in Texas and levels of various phytonutrients

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