Separation and composition of the phospholipids of ox heart

Gray, Gary M.; Macfarlane, Marjorie G.

doi:10.1042/bj0700409

Cited by 161 publications

(48 citation statements)

References 18 publications

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“…Thus these values indicate that the digitonin treatment results in a loss of about 3-33 moles of phospholipid fatty acid ester/mole of neutrallipid ester lost. The fatty acid distribution in the lysocardiolipin fraction (peak 1) was similar to that of the cardiolipin fraction analysed by Gray & Macfarlane (1958) and Getz & Bartley (1959). The main difference is a somewhat higher proportion of linoloic acid and only half the amount of oleic acid.…”

Section: Discussionmentioning

confidence: 52%

The lipid composition of phosphorylating ‘digitonin particles’ and water- and saline-extracted mitochondria from rat liver

Bartley

Getz

Notton

et al. 1962

Biochemical Journal

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Section: Discussionmentioning

confidence: 52%

The lipid composition of phosphorylating ‘digitonin particles’ and water- and saline-extracted mitochondria from rat liver

Bartley

Getz

Notton

et al. 1962

Biochemical Journal

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“…Additional information on tumour phospholipids was obtained from analysis of BP 8/C 3H ascitessarcoma cells. Previous studies of the phospholipid composition and the fatty acid and aldehyde distribution in a variety of normal tissues (Gray & Macfarlane, 1958Gray, 1960a, b) provided reasonable comparative data. The possible presence of unusual minor lipid components was borne in mind throughout this work, part of which was described by .…”

mentioning

confidence: 92%

The lipid composition of tumour cells

Gray¹

1963

Biochemical Journal

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SUMMARY1. Adenosine 5'-phosphate is converted into ATP by the combined action of adenylate kinase (adenosine triphosphate-adenosine monophosphate phosphotransferase) and creatine kinase (adenosine triphosphate-creatine phosphotransferase) in the presence of phosphocreatine, according to the equation:AMP + 2 phosphocreatine -+ ATP + 2 creatine.The conversion is not prevented as a result of treatment of the kinases with charcoal and Dowex 1 (CF-form) to remove nucleotides.2. It has been confirmed that neither creatine kinase nor adenylate kinase catalyses the direct phosphorylation of AMP by phosphocreatine.3. It appears that reaction occurs because crystalline creatine kinase contains a sufficient amount of ATP, even after treatment with charcoal and Dowex 1, to prime an autocatalytic system consisting of these reactions:AMP + ATP -+2 ADP and ADP + phosphocreatine -+ ATP + creatine (catalysed by adenylate kinase and creatine kinase respectively).

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“…In general, cardiolipins isolated from mammalian sources are highly unsaturated and specifically enriched in linoleic acid [3]. Several studies have indicated that this lipid is involved in different inner mitochondrial membrane functions.…”

Section: Introductionmentioning

confidence: 99%