Separation and Characterization of the Molecular Species of Thrombomodulin in the Plasma of Diabetic Patients

Uehara, Soichiro; Gotoh, Katuhiro; Handa, Hiroshi

doi:10.1016/s0049-3848(01)00358-9

Cited by 20 publications

(25 citation statements)

References 18 publications

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“…This observation is consistent with findings that HMGB1 and receptors for AGE are blocked by THBDD1, thereby inhibiting a NG (5 mmol/l) HMGB1-mediated inflammatory reactions [25]. Increased serum levels of THBD domains have been observed in patients with diabetes [31][32][33] and some specific forms of THBD domains were differentially expressed in patients with DN and non-diabetic nephritis [33]; however, the role of THBD in these renal conditions was not determined. In the present study, the beneficial effects of THBDD1 on the db/db mice treated suggest that THBD may be protective to diabetes-associated renal damage, although further investigation on this point is warranted.…”

Section: Discussionsupporting

confidence: 83%

Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

Yang¹,

Ka²,

et al. 2013

Diabetologia

100

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Aims/hypothesis Chronic inflammatory processes have been increasingly shown to be involved in the pathogenesis of diabetes and diabetic nephropathy. Recently, we demonstrated that a lectin-like domain of thrombomodulin (THBD), which is known as THBD domain 1 (THBDD1) and which acts independently of protein C activation, neutralised an inflammatory response in a mouse model of sepsis. Here, therapeutic effects of gene therapy with adeno-associated virus (AAV)-carried THBDD1 (AAV-THBDD1 ) were tested in a mouse model of type 2 diabetic nephropathy.Electronic supplementary material The online version of this article

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Section: Discussionsupporting

confidence: 83%

Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

Yang¹,

Ka²,

et al. 2013

Diabetologia

100

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“…Up to seven molecular subspecies of sTM have been reported, the relative proportions of which appear to differ between diabetes patients and healthy control subjects [2]. Although sTM fragments have anticoagulant activity, their physiological role is unknown.…”

Section: Introductionmentioning

confidence: 99%

Soluble thrombomodulin as a predictor of type 2 diabetes: results from the MONICA/KORA Augsburg case–cohort study, 1984–1998

et al. 2006

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Aims/hypothesis Previous studies have shown an inverse association between soluble thrombomodulin (sTM) and incident CHD, but there is a lack of data on the association between sTM and type 2 diabetes. Since CHD and type 2 diabetes share many risk factors, the aim of this study was to assess whether elevated sTM levels are associated with a lower incidence of type 2 diabetes. Materials and methods A case-cohort study was performed in initially healthy middle-aged men and women based on data from the Monitoring of Trends and Determinants in Cardiovascular Disease/Cooperative Health Research in the Region of Augsburg (MONICA/KORA) studies conducted between 1984 and 1998. Levels of sTM were measured with an ELISA in serum samples from 138 men and 86 women who developed type 2 diabetes during follow-up (cases) and 534 men and 446 women who did not develop type 2 diabetes (non-cases).Results An inverse association was found between sTM and type 2 diabetes risk after multivariable adjustment for diabetes risk factors, including several other markers of inflammation and endothelial dysfunction. Markers of inflammation and endothelial dysfunction were particularly strong confounders of the observed association. In the fully adjusted model, a 1 SD increase in sTM was associated with a 27% decrease in the risk of type 2 diabetes (hazard ratio=0.73, 95% CI 0.58-0.91) in the total study population. We did not observe significant risk differences between men and women. Conclusions/interpretation These data suggest that, in initially healthy middle-aged men and women, levels of sTM are inversely associated with the risk of type 2 diabetes.

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“…Sebagian reseptor di permukaan sel endotel ialah trombomodulin (TM), thrombospondin (TSP), CD 36 , ICAM-1, E-selectin, VCAM-1, PECAM-1, P-selectint berinteraksi dengan eritrosit yang terinfeksi parasit (PRBC) melalui PECAM-1. 6,13,21,22 Ohnishi dkk, 3 melakukan penelitian di Jepang pada 6 pasien malaria tertiana dengan menghubungkan serum TM, ICAM-1, VCAM-1, E-selectin. Terdapat hubungan yang antara serum TM antara kelompok malaria tertiana dengan kelompok kontrol (p<0,005).…”

Section: Diskusiunclassified

“…Aktivasi dari sel endotel yang diakibatkan oleh adhesi eritrosit yang terinfeksi mengakibatkan TM berlebihan keluar dari permukaan sel endotel. 6,13,21,22 Pada penelitian ini, hasil uji t menunjukkan perbedaan kadar TM untuk mendeteksi kerusakan sel endotel antara malaria tropika dengan komplikasi dan tanpa komplikasi (p=0,009). Penelitian ini hampir sama hasilnya dengan penelitian yang dilakukan Rogerson dkk, 9 di Malawi pada 155 anak.…”

Section: Diskusiunclassified

“…[3][4][5] Trombomodulin ini meningkat pada malaria tropika dan malaria tertiana, diabetes mellitus, lupus eritematosus sistemik, penyakit Kawasaki, gromerulonefritis akut dan disseminated intravascular coagulation. [6][7][8][9] Ohnishi dkk, 3 mendapatkan bahwa TM disekresi setelah terjadi kerusakan seluler sel endotel. Kerusakan sel endotel terjadi oleh karena interaksi antara eritrosit yang terinfeksi dan yang tidak terinfeksi pada kasus malaria tropika dan malaria tertiana.…”

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Peran Trombomodulin untuk Mendeteksi Kerusakan Sel Endotel pada Malaria Tropika dan Malaria Tertiana

Mantik

Rampengan

Kilis

et al. 2016

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Separation and Characterization of the Molecular Species of Thrombomodulin in the Plasma of Diabetic Patients

Cited by 20 publications

References 18 publications

Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

Soluble thrombomodulin as a predictor of type 2 diabetes: results from the MONICA/KORA Augsburg case–cohort study, 1984–1998

Peran Trombomodulin untuk Mendeteksi Kerusakan Sel Endotel pada Malaria Tropika dan Malaria Tertiana

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