Separation and assay of<sup>14</sup>C-labeled glyceryl trinitrate and its metabolites by OPLC coupled with on-line or off-line radioactivity detection

Klebovich, Imre; Morovján, György; Hazai, I.; Mincsovics, Emil

doi:10.1556/jpc.15.2002.6.2

Cited by 12 publications

(2 citation statements)

References 6 publications

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“…This advantage can easily be recognized when a radiolabeled compound and all metabolites are to be detected (69,70). Mincsovics et al (71) demonstrated the capacity for the preparative (more exactly, micropreparative) application of OPLC using continuous development.…”

Section: Discussionmentioning

confidence: 99%

Forced-Flow Planar Chromatography in the Rear View Mirror

Kalász

2015

Journal of Chromatographic Science

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Mobile phase progress in planar stationary phase can be evoked by either external or internal forces. An internal force is capillarity, while gravity, electric field, a pump and centrifugal forces belong to external forces. Overpressured layer chromatography gives a widely used special chapter of forced-flow planar chromatography, a special bridge between high-performance liquid column chromatography and thin-layer chromatography (TLC). A simple and special rule characterizes the progress of mobile phase. Optimal efficiency is composed by the doubled effect of flow resulting from the pump-forced mobile phase (convex profile of laminar flow) and capillary forces on the dry stationary phase (concave laminar flow). This review describes the most important aspects of forced-flow TLC, including how the set-ups are developed and also the progress of detection methods used.

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Section: Discussionmentioning

confidence: 99%

Forced-Flow Planar Chromatography in the Rear View Mirror

Kalász

2015

Journal of Chromatographic Science

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“…GTN and its metabolites have been separated and detected in rat plasma using the radioactivity detections previously mentioned. It should be noted that after on-line detection the adsorbent layer can be open and the components remaining there can be measured 'in-situ' by off-line detections (DAR and PIT) [85].…”

Section: Oplc With Radioactivity Detectionmentioning

confidence: 99%

Overpressured Layer Chromatography (OPLC) – A Flexible Tool of Analysis and Isolation

Mincsovics¹,

Tyihák

2011

Natural Product Communications

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This review briefly summarizes the overpressured layer chromatography (OPLC) technique and its progress from the beginning until today. Some theoretical aspects, important technical and methodological solutions, as well as analytical separations and isolations are demonstrated covering the last 30 years. The infusion and transfusion OPLC operations, as well as their combination, and their off-line and on-line processes, and off-line and on-line hyphenations for detection and structure elucidation are presented. The combination of OPLC separation with biological detection by direct bioautography and BioArena as an important solution touches the potential of analysis and isolation based on biological activity.

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Overpressured-layer chromatography

Tyihák

Móricz

Mincsovics

2016

Forced-Flow Layer Chromatography

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Separation and assay of¹⁴C-labeled glyceryl trinitrate and its metabolites by OPLC coupled with on-line or off-line radioactivity detection

Cited by 12 publications

References 6 publications

Forced-Flow Planar Chromatography in the Rear View Mirror

Forced-Flow Planar Chromatography in the Rear View Mirror

Overpressured Layer Chromatography (OPLC) – A Flexible Tool of Analysis and Isolation

Overpressured-layer chromatography

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Separation and assay of14C-labeled glyceryl trinitrate and its metabolites by OPLC coupled with on-line or off-line radioactivity detection

Cited by 12 publications

References 6 publications

Forced-Flow Planar Chromatography in the Rear View Mirror

Forced-Flow Planar Chromatography in the Rear View Mirror

Overpressured Layer Chromatography (OPLC) – A Flexible Tool of Analysis and Isolation

Overpressured-layer chromatography

Contact Info

Product

Resources

About

Separation and assay of¹⁴C-labeled glyceryl trinitrate and its metabolites by OPLC coupled with on-line or off-line radioactivity detection