Sentinel node biopsy for oral cancer: A prospective multicenter Phase II trial

Miura, Kouki; Hirakawa, Hitoshi; Uemura, Hirokazu; Yoshimoto, Seiichi; Shiotani, Akiko; Sugasawa, Masashi; Homma, Akihiro; Yokoyama, Junkichi; Tsukahara, Kiyoaki; Yoshizaki, Tomokazu; Yatabe, Yasushi; Matsuo, Keitaro; Ohkura, Yasuo; Kosuda, Shigeru; Hasegawa, Yasuhisa

doi:10.1016/j.anl.2016.07.008

Cited by 50 publications

(47 citation statements)

References 37 publications

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“…A recent meta‐analysis which included 3566 patients, found the sensitivity and negative predictive value of SNB to be 87% and 94%, respectively . Additional prospective and retrospective studies have all provided results consistent with this meta‐analysis …”

Section: Introductionsupporting

confidence: 73%

“…20,21 Sentinel node biopsy has emerged as a viable, minimally invasive technique for staging the cN0 neck. [4][5][6][7][8][9][10][11][12] Furthermore, SNB provides the option of more intensive pathological analysis, including tumor marker status and HPV status, which have recently been incorporated into standard clinical practice. 3 should undergo further treatment.…”

Section: Resultsmentioning

confidence: 99%

“…5 Additional prospective and retrospective studies have all provided results consistent with this meta-analysis. [8][9][10][11][12] Our objective has been to assess clinical outcomes of patients with OSCC after SNB is used as a cN0 staging procedure. We continue to evaluate SNBʼs efficacy as we build upon this objective by increasing our sample size to further substantiate previous results in a large scale, single institution review of SNB in the management of the cN0 OSCC.…”

Section: Introductionmentioning

confidence: 99%

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Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma

Loree

Popat

Burke

et al. 2019

Journal of Surgical Oncology

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Background and Objectives The management of the clinically N0 (cN0) neck is controversial for early stage squamous cell carcinoma of the oral cavity (OSCC). This paper represents a single institution series analyzing the efficacy of sentinel lymph node biopsy (SNB) for early stage oral cavity cancers. Methods From 2005 to 2017, 108 patients with cN0 OSCC were treated with primary resection and SNB. Patients with positive biopsy results proceeded to neck dissection with or without adjuvant chemoradiotherapy. Mean follow‐up for the entire cohort was 50.8 months (range: 8‐147 months). Clinically, 56 patients were T1N0, 49 patients were T2N0, and three patients were T3N0 or greater. Results Disease‐specific survival was 93% within the entire cohort. Sentinel lymph nodes were identified in 95.4% of patients. Twenty one patients had a positive biopsy. There were seven false‐negative biopsies. The overall rate of nodal disease was 26%. Accuracy of node biopsy was 93%, with sensitivity of 75%, and negative predictive value of 91%. Recurrence rate was 19% (20/108), with an overall survival of 60% in this subgroup. Conclusion SNB is a safe, effective, and well tolerated method for staging cN0 OSCC.

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Section: Introductionsupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma

Loree

Popat

Burke

et al. 2019

Journal of Surgical Oncology

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“…Patients with transorally resectable T1 or T2 cN0 oropharyngeal/hypopharyngeal/supraglottic cancer were enrolled between January 2013 and March 2015 from seven institutions (Aichi Cancer Center, National Defense Medical College, Kyoto University, Juntendo University, Tokyo Medical University, Hokkaido University, and National Cancer Center Hospital) according to the criteria previously reported . Cases with carcinoma in situ, adjuvant treatment before surgery, recurrence after curative treatment, radiation treatment in the neck, patients younger than 18 years, and pregnant women or those currently lactating were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…With respect to SNNS in HNSCC, although early oral and oropharyngeal cancers have been the most studied cancers, there have been few reports on laryngopharyngeal cancer . One reason for this drawback is that radionucleotide (RN) tracers, which are major tracers for SNNS in HNSCC, cannot be administered in the operation room (OR).…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive surgery for laryngopharyngeal cancer: Multicenter feasibility study of a combination strategy involving transoral surgery and real‐time indocyanine green fluorescence‐navigated sentinel node navigation surgery

et al. 2019

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Background: Sentinel node navigation surgery using indocyanine green (ICG-SNNS) can be performed in the operation room. The combination of minimally invasive transoral surgery (TOS) with ICG-SNNS can provide functional preservation options for both primary lesions and lymph node (LN) metastasis. This multicenter feasibility study of this strategy was conducted in Japan. Methods: Patients with clinical T1 or T2, N0 oropharyngeal, hypopharyngeal, or supraglottic cancer were enrolled. The identification rate of sentinel nodes, delayed cervical LN metastasis in 2 years, and survival rate were assessed. Results: Twenty-two patients (10 oropharynx, 8 hypopharynx, 4 supraglottic cancer) were enrolled. The identification rate was 100%. One case had delayed nodal metastasis. The accuracy was 95.5%, sensitivity was 75%, and specificity was 100%. The 5-year disease-specific survival was 100%, overall survival was 72.3%, and disease-free survival was 60.5%. Conclusions: The combination of TOS with ICG-SNNS is feasible as a minimally invasive strategy and has favorable oncological outcomes. K E Y W O R D Sindocyanine green, laryngeal cancer, pharyngeal cancer, sentinel lymph node, transoral surgery A part of this research was presented at

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Sentinel lymph node biopsy versus elective neck dissection in squamous cell carcinoma of the oral cavity with a clinically N0 neck: Systematic review and meta‐analysis of prospective studies

Ding

Pan

et al. 2021

Head & Neck

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Sentinel lymph node biopsy (SLNB) is an emerging strategy for managing early‐stage oral squamous cell carcinoma (SCC) with a clinically N0 (cN0) neck. However, the role of SLNB in this scenario is debatable. Herein, relevant literature was systematically reviewed, and a meta‐analysis was performed to evaluate the potential dividends of SLNB compared to elective neck dissection (END) for these patients. The meta‐analysis, including six prospective studies, showed comparable results of the two management strategies in terms of regional recurrence (risk ratio [RR] = 0.99; 95% confidence interval [CI], 0.58–1.70), 5‐year disease‐free survival (RR = 0.99; 95% CI, 0.87–1.11), and 5‐year overall survival (RR = 1.01; 95% CI, 0.90–1.13). Fewer adverse events occurred in the SLNB arm than in the END arm (RR = 0.12; 95% CI, 0.02–0.70). Overall, SLNB results in as favorable an oncologic prognosis for patients with cN0 oral SCC as END, while significantly lessening side effects and unnecessary surgeries.

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Sentinel node biopsy for oral cancer: A prospective multicenter Phase II trial

Cited by 50 publications

References 37 publications

Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma

Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma

Minimally invasive surgery for laryngopharyngeal cancer: Multicenter feasibility study of a combination strategy involving transoral surgery and real‐time indocyanine green fluorescence‐navigated sentinel node navigation surgery

Sentinel lymph node biopsy versus elective neck dissection in squamous cell carcinoma of the oral cavity with a clinically N0 neck: Systematic review and meta‐analysis of prospective studies

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