Sentinel node biopsy for early‐stage oral cavity cancer: the VU University Medical Center experience

Toom, Inne J den; Heuveling, Derrek A.; Flach, Géke B.; Weert, Stijn van; Karagozoglu, K.H.; Schie, Annelies van; Bloemena, Elisabeth; Leemans, C. René; Bree, Remco de

doi:10.1002/hed.23632

Cited by 69 publications

(49 citation statements)

References 40 publications

(82 reference statements)

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“…In a previous publication of a series of 90 patients from our institute, these figures were 93% and 97%, respectively, in which fhSPECT was used in only a minority of patients [15]. However, we cannot conclude that this lower sensitivity is due to the use of fhSPECT, since none of the nodal recurrences (in 2 patients) occurred in a level of the neck were the SN was intra-operatively undetectable.…”

Section: Discussionmentioning

confidence: 67%

Evaluation of the use of freehand SPECT for sentinel node biopsy in early stage oral carcinoma

et al. 2015

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Section: Discussionmentioning

confidence: 67%

Evaluation of the use of freehand SPECT for sentinel node biopsy in early stage oral carcinoma

et al. 2015

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“…The SLNB was performed according to the EANM/SENT joint practice guidelines [7]. In this article, we describe only the imaging part of the procedure in our institution in detail, as the entire procedure had been previously described [8]. …”

Section: Methodsmentioning

confidence: 99%

The added value of SPECT-CT for the identification of sentinel lymph nodes in early stage oral cancer

Toom

Schie

Weert

et al. 2017

Eur J Nucl Med Mol Imaging

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PurposeTo assess the role of single-photon emission computed tomography with computed tomography (SPECT-CT) for the identification of sentinel lymph nodes (SLNs) in patients with early stage (T1–T2) oral cancer and a clinically negative neck (cN0).MethodsIn addition to planar lymphoscintigraphy, SPECT-CT was performed in 66 consecutive patients with early stage oral cancer and a clinically negative neck. The addition of SPECT-CT to planar images was retrospectively analyzed for the number of additional SLNs, more precise localization of SLNs, and importance of anatomical information by a team consisting of a nuclear physician, surgeon, and investigator.ResultsIdentification rate for both imaging modalities combined was 98% (65/66). SPECT-CT identified 15 additional SLNs in 14 patients (22%). In 2/15 (13%) of these additional SLNs, the only metastasis was found, resulting in an upstaging rate of 3% (2/65). In 20% of the patients with at least one positive SLN, the only positive SLN was detected due to the addition of SPECT-CT. SPECT-CT was considered to add important anatomical information in two patients (3%). In 5/65 (8%) of the patients initially scored SLNs on planar lymphoscintigrams were scored as non-SLNs when SPECT-CT was added. There were four false-negative SLN biopsy procedures in this cohort.ConclusionsThe addition of SPECT-CT to planar lymphoscintigraphy is recommended for the identification of more (positive) SLNs and better topographical orientation for surgery in sentinel lymph node biopsy for early stage oral cancer.

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“…4 More recently, a retrospective study of 90 previously untreated patients with early OSCC with a cN0 neck who underwent SNB (only neck dissection after positive findings on SNB) was performed: A lymphoscintigraphic identification rate of 98%, a surgical detection rate of 99%, and an upstaging rate of 30% were found. 5 SNB has been extensively used in skin cancer, particularly melanoma. 6 Although less invasive compared with elective neck dissection, SNB is still a surgical procedure.…”

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confidence: 99%

Fusion of Freehand SPECT and Ultrasound to Perform Ultrasound-Guided Fine-Needle Aspiration Cytology of Sentinel Nodes in Head and Neck Cancer

Bree

Pouw

Heuveling³

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Criteria for ultrasound-guided fine-needle aspiration cytology (USgFNAC) for the detection of occult lymph node metastasis in patients with clinically negative head and neck cancer are based on the morphology of cervical lymph nodes. To improve the selection of lymph nodes for USgFNAC, we examined the feasibility of fused freehand single-photon emission tomography ultrasound-guided fine-needle cytology (freehand SPECT-USgFNAC) of sentinel nodes in patients with early stage oral and head and neck skin cancer.

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Sentinel node biopsy for early‐stage oral cavity cancer: the VU University Medical Center experience

Abstract: SNB is a reliable diagnostic staging technique for the clinically negative neck in patients with early-stage (T1-T2, cN0) oral squamous cell carcinoma.

Cited by 69 publications

References 40 publications

Evaluation of the use of freehand SPECT for sentinel node biopsy in early stage oral carcinoma

Evaluation of the use of freehand SPECT for sentinel node biopsy in early stage oral carcinoma

The added value of SPECT-CT for the identification of sentinel lymph nodes in early stage oral cancer

Fusion of Freehand SPECT and Ultrasound to Perform Ultrasound-Guided Fine-Needle Aspiration Cytology of Sentinel Nodes in Head and Neck Cancer

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