Evaluation of the use of freehand SPECT for sentinel node biopsy in early stage oral carcinoma

Heuveling, Derrek A.; Weert, Stijn van; Karagozoglu, K.H.; Bree, Remco de

doi:10.1016/j.oraloncology.2014.12.001

Cited by 47 publications

(37 citation statements)

References 17 publications

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“…Moreover, freehand SPECT provides helpful information facilitating the SN biopsy procedure in a quarter of cases. 24 Freehand SPECT has also been used successfully in malignant melanoma to facilitate the detection and resection of SNs.…”

Section: Discussionmentioning

confidence: 99%

“…However, some technical limitations were shown in freehand SPECT quality and fusion precision. 23,24 The use of a hand-held gamma camera instead of a gamma probe and proper stabilization of the neck as shown in this preliminary study seem to overcome these difficulties. Recently, it has been shown that freehand SPECT-USguided needle biopsy of sentinel lymph nodes in the axilla is feasible.…”

mentioning

confidence: 88%

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Fusion of Freehand SPECT and Ultrasound to Perform Ultrasound-Guided Fine-Needle Aspiration Cytology of Sentinel Nodes in Head and Neck Cancer

Bree

Pouw

Heuveling³

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Criteria for ultrasound-guided fine-needle aspiration cytology (USgFNAC) for the detection of occult lymph node metastasis in patients with clinically negative head and neck cancer are based on the morphology of cervical lymph nodes. To improve the selection of lymph nodes for USgFNAC, we examined the feasibility of fused freehand single-photon emission tomography ultrasound-guided fine-needle cytology (freehand SPECT-USgFNAC) of sentinel nodes in patients with early stage oral and head and neck skin cancer.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 88%

Fusion of Freehand SPECT and Ultrasound to Perform Ultrasound-Guided Fine-Needle Aspiration Cytology of Sentinel Nodes in Head and Neck Cancer

Bree

Pouw

Heuveling³

et al. 2015

AJNR Am J Neuroradiol

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“…Encouraging results have been reported in patients with melanoma and breast cancer [12,13] as well as initial reports in tumours of the head and neck (HN) region [8,11,[14][15][16][17][18]. Once validated, this system has the potential to replace conventional outpatient-based SPECT-CT imaging with an intraoperative technique and open new applications for sentinel node biopsy in previously inaccessible tumours.…”

Section: Introductionmentioning

confidence: 89%

Role of intraoperative sentinel node imaging in head and neck cancer

Schilling

Corrado

Gnanasegaran

et al. 2015

Clin Transl Imaging

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At the present time, there is a dilemma concerning the best management of the neck in patients presenting with early head and neck squamous cell carcinoma (HNSCC). Occult cervical metastasis is found in up to a quarter of HNSCC patients with radiologically N0 necks, and for this reason, conventional treatment includes elective neck dissection (END) alongside tumour excision. Sentinel node biopsy (SNB) offers an alternative accurate and minimally invasive method of staging the neck, which has been safely applied to oral cancer. SNB is a patientspecific procedure which has an enhanced recovery compared to END but is currently not widely offered to patients. There are exciting developments in the technology supporting SNB, improving the accuracy and ease of the procedure and opening up the technique to new tumour types. We describe our experiences in using a novel intraoperative navigation device for sentinel node retrieval and review other advances in SNB practice which have the potential to change the standard management for patients with early HNSCC.Keywords Sentinel node biopsy Á Freehand SPECT Á Head and neck squamous cell carcinoma Á Cervical metastasis Á Guided intraoperative scintigraphic tumour targeting (GOSTT)

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“…However, spatial resolution remained non-satisfactory (1-2 cm). 12 Another limitation of lymphoscintigraphy is the socalled "shine-through effect", which is encountered during SLN biopsy in Level I in cases with primary lesion situated on the floor of the mouth. The radiation counts of the primary site overshadow the SLN site background counts, which brings difficulties for its detection by the gamma probe and accordingly its proper intraoperative localization.…”

Section: Resultsmentioning

confidence: 99%

Contrast-enhanced ultrasound mapping of sentinel lymph nodes in oral tongue cancer—a pilot study

Gvetadze

Xiong

et al. 2017

Dentomaxillofacial Radiology

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Objectives: To assess the usefulness of contrast-enhanced ultrasound (CEUS) with peritumoral injection of microbubble contrast agent for detecting the sentinel lymph nodes for oral tongue carcinoma. Methods: The study was carried out on 12 patients with T1-2cN0 oral tongue cancer. A radical resection of the primary disease was planned; a modified radical supraomohyoid neck dissection was reserved for patients with larger lesions (T2, n 5 8). The treatment plan and execution were not influenced by sentinel node mapping outcome. The SonovueÔ contrast agent (Bracco Imaging, Milan, Italy) was utilized. After detection, the position and radiologic features of the sentinel nodes were recorded. Results: The identification rate of the sentinel nodes was 91.7%; one patient failed to demonstrate any enhanced areas. A total of 15 sentinel nodes were found in the rest of the 11 cases, with a mean of 1.4 nodes for each patient. The sentinel nodes were localized in: Level IA-1 (6.7%) node; Level IB-11 (73.3%) nodes; Level IIA-3 (20.0%) nodes. No contrastrelated adverse effects were observed. Conclusions: For oral tongue tumours, CEUS is a feasible and potentially widely available approach of sentinel node mapping. Further clinical research is required to establish the position of CEUS detection of the sentinel nodes in oral cavity cancers. Dentomaxillofacial Radiology (2017Radiology ( ) 46, 20160345. doi: 10.1259 Cite this article as: Gvetadze SR, Xiong P, Lv M, Li J, Hu J, Ilkaev KD, et al. Contrastenhanced ultrasound mapping of sentinel lymph nodes in oral tongue cancer-a pilot study.

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Evaluation of the use of freehand SPECT for sentinel node biopsy in early stage oral carcinoma

Cited by 47 publications

References 17 publications

Fusion of Freehand SPECT and Ultrasound to Perform Ultrasound-Guided Fine-Needle Aspiration Cytology of Sentinel Nodes in Head and Neck Cancer

Fusion of Freehand SPECT and Ultrasound to Perform Ultrasound-Guided Fine-Needle Aspiration Cytology of Sentinel Nodes in Head and Neck Cancer

Role of intraoperative sentinel node imaging in head and neck cancer

Contrast-enhanced ultrasound mapping of sentinel lymph nodes in oral tongue cancer—a pilot study

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