Sentinel Lymph Node Biopsy in Patients with Previous Ipsilateral Complete Axillary Lymph Node Dissection

Kaur, Paramjeet; Kiluk, John V.; Meade, Tammi; Ramos, Daniel; Koeppel, William; Jara, J; King, Jeff; Cox, Charles E.

doi:10.1245/s10434-010-1120-2

Cited by 45 publications

(22 citation statements)

References 18 publications

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“…Sentinel node biopsy in patients undergoing postoperative axillary surgery has been described in several articles [41]–[45]. In 11 (8%) of 135 patients who underwent reoperative sentinel node biopsy with successful mapping, the sentinel node was the contralateral axillary lymph node, and in 6 patients (4%), the ipsilateral clavicular node was the sentinel node.…”

Section: Discussionmentioning

confidence: 99%

Lymphatic Territories (Lymphosomes) in a Canine: An Animal Model for Investigation of Postoperative Lymphatic Alterations

et al. 2013

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BackgroundLymph node dissection is often performed as a part of surgical treatment for breast cancer and malignant melanoma to prevent malignant cells from traveling via the lymphatic system. Currently little is known about postoperative lymphatic drainage pattern alterations. This knowledge may be useful for management of recurrent cancer and prevention of breast cancer related lymphedema. We mapped the complete superficial lymphatic system of a dog and used this canine model to perform preliminary studies of lymphatic architectural changes in postoperative condition.MethodsLymphatic territories (lymphosomes) were mapped with 4 female mongrel carcasses using an indocyanine green (ICG) fluorescent lymphography and a radiographic microinjection technique. Two live dogs were then subjected to unilateral lymph node dissection of lymph basins of the forelimb, and ICG lymphography and lymphangiogram were performed 6 months after the surgery to investigate lymphatic changes. Lymphatic patterns in the carcass were then compared with postoperative lymphatic patterns in the live dogs.ResultsTen lymphosomes were identified, corresponding with ten lymphatic basins. Postoperative fluorescent lymphographic images and lymphangiograms in the live dogs revealed small caliber lymphatic network fulfilling gaps in the surgical area and collateral lymphatic vessels arising from the network connecting to lymph nodes in the contralateral and ipsilateral neck in one dog and the ipsilateral subclavicular vein in another dog.ConclusionOur canine lymphosome map allowed us to observe lymphatic collateral formations after lymph node dissection in live dogs. This canine model may help clarify our understanding of postoperative lymphatic changes in humans in future studies.

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Section: Discussionmentioning

confidence: 99%

Lymphatic Territories (Lymphosomes) in a Canine: An Animal Model for Investigation of Postoperative Lymphatic Alterations

et al. 2013

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“…Van Wely et al [13] also did not meet the PICO question since they published a mini review showing the association between lower rates of local recurrence and external beam radiation after negative sentinel lymph node detection. Kaur et al [14] reported that remapping of lymph nodes after prior completion of axillary lymph node dissection is feasible and should be considered regardless of the number of initially removed lymph nodes. Although these results are interesting for the management of recurrent disease, they still do not answer our question concerning a comparison of the treatment options in LNRD.…”

Section: Resultsmentioning

confidence: 99%

Implementation of a Systematic Literature Search Strategy in a National Breast Cancer Guideline: The Relevance of Systemic Therapy in Lymph Node Recurrent Disease

Stueber¹,

Stangl²,

Jackisch³

et al. 2018

Oncol Res Treat

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Purpose:Our aim was to implement a structured literature search using PICO (patient/intervention/comparison/outcome) questions and a standardized consensus method for the German Guideline ‘Detection, diagnostics, therapy and follow-up of Breast Cancer' using, as an example, the significance of systemic therapy in lymph node recurrent disease (LNRD). Methods: We defined specified PICO questions according to the clinical significance of a recommendation for systemic therapies in locoregional LNRD. A methodologist performed a systematic literature search including randomized controlled trials, systematic reviews and observational studies (2007-2016). In a consensus conference, the level of evidence and consensus was determined and the clinical recommendation was adopted. Results: In total 143 publications were identified according to the search strategy including 14 duplicates, which were excluded. 4 publications were included based on experts' choice. The team excluded 119 publications, leaving 14 that were then screened by a full text search. Finally, 1 publication was found to be of methodologically and clinically reliable content. The conclusion of this publication in favor of systemic therapy for LNRD received strong consent from the consensus conference. Conclusions: The literature search strategy using PICO questions helped to achieve a fast and standardized selection of publications. The recommendation concerning systemic treatment of LNRD was first implemented in the update of the German Breast Cancer guideline.

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“…Grundsätzlich kann auch nach BET und vorangegangener Radiotherapie der Brust beim intramammären Rezidiv eine erneute Sentinel-Lymphknotenbiopsie (SLNB) empfohlen und durchgeführt werden [17]. Dabei ist zu beachten, dass bei einer Re-SLNB nach primär erfolgter SLNB eine geringere Detektionsrate zu erwarten ist [18].…”

Section: Frage 3: Sollte Bei Einem Lokalrezidiv In Der Brust Und Aktuunclassified

Behandlung des lokoregionären Rezidivs unter besonderer Berücksichtigung der HER2-positiven Rezidive

Jackisch¹,

Schneeweiß²,

Untch³

et al. 2013

Breast Care

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Sentinel Lymph Node Biopsy in Patients with Previous Ipsilateral Complete Axillary Lymph Node Dissection

Abstract: Reoperative SLN mapping and biopsy is feasible in the setting of local recurrence after previous CALND. This procedure performed for breast cancer recurrence provides important staging information while identifying extra-axillary drainage that could affect both staging and local control.

Cited by 45 publications

References 18 publications

Lymphatic Territories (Lymphosomes) in a Canine: An Animal Model for Investigation of Postoperative Lymphatic Alterations

Lymphatic Territories (Lymphosomes) in a Canine: An Animal Model for Investigation of Postoperative Lymphatic Alterations

Implementation of a Systematic Literature Search Strategy in a National Breast Cancer Guideline: The Relevance of Systemic Therapy in Lymph Node Recurrent Disease

Behandlung des lokoregionären Rezidivs unter besonderer Berücksichtigung der HER2-positiven Rezidive

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