Sentinel lymph node biopsy for ocular adnexal melanoma

Abstract

SLNB in patients with ocular adnexal melanoma is safe and identifies nodal micrometastasis in approximately 20% of cases. Histologic features associated with a positive SLN included greater tumour thickness, greater number of mitotic figures and ulceration.

Sentinel Lymph Node Biopsy in the Setting of Conjunctival Melanoma: Report of Two Cases and Literature Review

“…In the last decade SLNM and SLNB for CM has evolved dramatically because it has been shown to detect regional lymph node spread with great accuracy and minimal morbidity [13,20]. The positivity SLNB rate ranges from 11% to 20% [13,21], with a false negativity rate of 8% [13]. Most of the data regarding SLNM and SLNB in CM come from small case series due to the rarity of this tumor, and controlled trials with uniform techniques are required to validate it use in CM.…”

Sentinel Lymph Node Biopsy for Conjunctival and Ocular Adnexal Tumors

“…Sentinel lymph node biopsy (SLNB) is a method of detecting subclinical (microscopic) metastasis in regional lymph node at risk of metastasis and can be used to detect early metastasis from eyelid and conjunctival malignancies. Sentinel lymph node biopsy has been demonstrated to be technically feasible and have a reasonable positive yield for various eyelid and conjunctival cancers including melanoma, squamous cell carcinoma (SCC), sebaceous gland carcinoma (SGCa), and Merkel cell carcinoma (MCC); these cancers have various risks of regional lymph node metastasis (Table 5.1) [1][2][3][4][5][6][7][8][9][10].…”

“…SLNB is based on the concept of an orderly drainage of tumor cells through the lymphatic drainage system before dissemination in the bloodstream and involvement of other organs. The sentinel lymph nodes (SLNs) or first draining node(s) for a tumor can be identified by injecting tracer molecules into Data from references [1][2][3][4][5][6][7][8][9][10] the tissue surrounding the tumor. Identification of SLN status provides the surgeon and the patient with valuable prognostic information [10].…”

Evaluation of Treatment Results According to Clinical AJCC Staging in Conjunctival Malignant Melanoma

“…25 Sistemik metastaz öncesinde lenf nodu tutulumu saptanan hastalarda, ilk olarak sistemik metastaz gelişenlere göre prognozun daha iyi olduğu bildirilmiştir. 26 Serimizde, metastaz gelişen toplam beş hastadan birinde ölüm görülmüştür. Bu hasta lenf nodu tutulumu olmadan doğrudan beyin metastazı gelişen bir hastadır.…”

“…Ancak, son dönemlerde lenf nodu tutulumunun erken dönemde belirlenmesinin sağkalım üzerine olumlu etkisi olduğu bildirilmekte ve tümör kalınlığının 2 mm'nin üzerinde olduğu hastalarda sentinel lenf nodu biyopsisi öne-rilmektedir. 25,26 Çeşitli çalışmalarda primer tümörün evresi, yerleşimi, boyutları, de novo gelişim ve nüks varlığı metastaz için bağımsız risk faktörleri olarak göste-rilmiştir. [16][17][18]21 Palpebral konjonktiva, forniks, plika, karünkül ve kapak kenarı yerleşimli konj MM, bulber yerleşimliler ile karşılaştırıldığında 2,2 kat fazla mortaliteye sahiptir.…”