Sensory regulation of dopaminergic cell activity: Phenomenology, circuitry and function

Overton, Paul G.; Vautrelle, Nicolas; Redgrave, Peter

doi:10.1016/j.neuroscience.2014.01.023

Cited by 30 publications

(22 citation statements)

References 123 publications

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“…While our previous and present studies demonstrated that under drug-induced conditions, innocuous sensory inputs produced a consistent suppression of psychomotor behaviors and DA release 11, 12, 25, 27 , others have shown mixed results in responses of midbrain DA neurons to innocuous stimulation in drug-naïve conditions. For examples, non-noxious stimuli such as foot pressure and cervical probing elicit short latency facilitation or inhibition of midbrain DA neurons in drug-naïve rats 28 . Innocuous sensory stimulation by electrical stimulation or 80–100 mmHg pressure to the skin can produce a slight decrease in DA release in the dorsal striatum 4, 5 or a mild increase in DA release in the NAc 15 .…”

Section: Discussionmentioning

confidence: 99%

Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine

Chang

Ryu

Gwak

et al. 2017

Sci Rep

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Previous studies have demonstrated that somatosensory stimuli influence dopamine transmission in the mesolimbic reward system and can reduce drug-induced motor behaviors, craving and dependence. Until now, the central links between somatosensory and brain reward systems are not known. Here, we show that the dorsal column (DC) somatosensory pathway contains projections that convey an inhibitory input from the periphery to mesolimbic reward circuits. Stimulation of the ulnar nerve under HT7 acupoint suppressed psychomotor response to cocaine, which was abolished by disruption of the DC pathway, but not the spinothalamic tract (STT). Low-threshold or wide-dynamic range neurons in the cuneate nucleus (CN) were excited by peripheral stimulation. Lesions of dorsal column or lateral habenula (LHb) prevented the inhibitory effects of peripheral stimulation on cocaine-induced neuronal activation in the nucleus accumbens (NAc). LHb neurons projecting to the ventral tegmental area (VTA)/rostromedial tegmental nucleus (RMTg) regions were activated by peripheral stimulation and LHb lesions reversed the inhibitory effects on cocaine locomotion produced by peripheral stimulation. These findings suggest that there exists a pathway in spinal cord that ascends from periphery to mesolimbic reward circuits (spino-mesolimbic pathway) and the activation of somatosensory input transmitted via the DC pathway can inhibit the psychomotor response to cocaine.

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Section: Discussionmentioning

confidence: 99%

Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine

Chang

Ryu

Gwak

et al. 2017

Sci Rep

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“…those without an existing positive or negative valence), especially if they are novel or otherwise behaviorally salient (Ljungberg et al, 1992; Redgrave et al, 1999; Horvitz, 2000). These responses, which are believed to be driven from the cortex via superior colliculus (Bertram et al, 2014), may have an alerting role and either enable learning about new stimuli or be important for behavioral switching (Overton et al, 2014). …”

Section: Dopamine Neuron Activity In Response To ‘Life Events’mentioning

confidence: 99%

Heterogeneity of dopamine neuron activity across traits and states

2014

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Midbrain dopamine neurons fire irregularly, with interspersed clusters of high-frequency spikes, commonly called ‘bursts’. In this review we examine such heterogeneity in activity, and provide insight into how it can participate in psychiatric conditions such as drug addiction. We first describe several techniques used to evaluate dopamine neuron activity, and comment on the different measures that each provides. We next describe the activity of dopamine neurons in ‘basal’ conditions. Specifically, we discuss how the use of anesthesia and reduced preparations may alter aspects of dopamine cell activity, and how there is heterogeneity across species and regions. We also describe how dopamine cell firing changes throughout the peri-adolescent period and how dopamine neuron activity differs across the population. In the final section, we discuss how dopamine neuron activity changes in response to life events. First, we focus attention on drugs of abuse. Drugs themselves change firing activity through a variety of mechanisms, with effects on firing while drug is present differing from those seen after drug discontinuation. We then review how stimuli that are rewarding, aversive, or salient can evoke changes in firing rate and discharge pattern of dopamine neurons, and provide behavioral relevance of dopamine signaling. Finally, we discuss how stress can modulate dopamine neuron firing and how this may contribute to the role that stressful experiences play in psychiatric disorders such as addiction and depression.

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“…Neuroscience 282 (2014) 198-216 Adan, 2014; Nikulina et al, 2014;Overton et al, 2014;Walsh and Han, 2014). While most work related to the dopamine cells of the VTA, recent attention has also been given to the GABA and glutamate cell populations (Roeper, 2013;Creed et al, 2014;Morales and Root, 2014).…”

Section: Introductionmentioning

confidence: 99%