The antero-posterior heterogeneity of the ventral tegmental area

Sánchez-Catalán, María José; Kaufling, Jennifer; Georges, François; Veinante, Pierre; Barrot, Michel

doi:10.1016/j.neuroscience.2014.09.025

Cited by 101 publications

(69 citation statements)

References 194 publications

(334 reference statements)

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“…Several evidences support the notion that the activation of MOP receptors expressed onto VTA GABA neurons and other GABA afferents (Johnson and North, 1992; Jalabert et al, 2011; Sánchez-Catalán et al, 2014), is critically involved in the stimulation of VTA DA neurons after ethanol or acetaldehyde (Mereu and Gessa, 1985; Xiao et al, 2007; Fois and Diana, 2016). Consistent with this idea, behavioral studies have shown that the microinjection of naltrexone or β-funaltrexamine (an irreversible MOP receptor antagonist) can prevent the motor activation induced by the intra-pVTA administration of ethanol or acetaldehyde (Sánchez-Catalán et al, 2009).…”

Section: Role Of Brain Ethanol-derived Acetaldehyde In the Effects Ofmentioning

confidence: 85%

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

Peana

Sánchez-Catalán

Hipólito

et al. 2017

Front. Behav. Neurosci.

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After decades of uncertainties and drawbacks, the study on the role and significance of acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the effects of acetaldehyde, after its systemic or central administration and as obtained following ethanol metabolism, looked as they were extensively characterized. However, almost 5 years after this research appeared at its highest momentum, the investigations on this topic have been revitalized on at least three main directions: (1) the role and the behavioral significance of acetaldehyde in different phases of ethanol self-administration and in voluntary ethanol consumption; (2) the distinction, in the central effects of ethanol, between those arising from its non-metabolized fraction and those attributable to ethanol-derived acetaldehyde; and (3) the role of the acetaldehyde-dopamine condensation product, salsolinol. The present review article aims at presenting and discussing prospectively the most recent data accumulated following these three research pathways on this never-ending story in order to offer the most up-to-date synoptic critical view on such still unresolved and exciting topic.

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Section: Role Of Brain Ethanol-derived Acetaldehyde In the Effects Ofmentioning

confidence: 85%

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

Peana

Sánchez-Catalán

Hipólito

et al. 2017

Front. Behav. Neurosci.

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“…The opposing valences of LHb and VTA/SNc responses to reward omission and aversive stimuli previously had been difficult to reconcile because the axonal projection from the LHb to the VTA is almost exclusively excitatory (Geisler et al, 2007; Brinschwitz et al, 2010), which dictated a need for an inhibitory intermediary – the RMTg, it turned out - to account for the functional findings (see the discussion in Ji and Shephard, 2007). RMTg has since been reviewed on numerous recent occasions (Barrot and Thome, 2011; Lavezzi and Zahm, 2011; Bourdy and Barrot, 2012; Sanchez-Catalan et al, 2014; Yetnikoff et al, 2014; Barrot et al, 2016; Zahm, 2016). Interestingly, while LHb lesions indisputably impair specific aspects of reward prediction error signaling in midbrain DA neurons, LHb may not be the exclusive source of such error signals (Tian and Uchida, 2015).…”

Section: Efferent Connectionsmentioning

confidence: 99%

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

Zahm

Root

2017

Pharmacology Biochemistry and Behavior

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The cytology and connections of the lateral habenula (LHb) are reviewed. The habenula is first introduced, after which the cytology of the LHb is discussed mainly with reference to cell types, general topography and descriptions of subnuclei. An overview of LHb afferent connections is given followed by some details about the projections to LHb from a number of structures. An overview of lateral habenula efferent connections is given followed by some details about the projections from LHb to a number of structures. In considering the afferent and efferent connections of the LHb some attention is given to the relative validity of regarding it as a bi-partite structure featuring ‘limbic’ and ‘pallidal’ parts. The paper ends with some concluding remarks about the relative place of the LHb in adaptive behaving.

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“…Rostrally, it starts within the VTA paranigral nucleus, and dorsolaterally to the interpeduncular nucleus. It then extends caudally and dorsally, laterally to the median raphe nuclei, and is partially embedded within the superior cerebellar peduncle fibers (Kaufling et al, 2010a;Sánchez-Catalán et al, 2014). We analyzed a section every 160 μm along the entire tVTA extent; after correction for missing sections, data were expressed per whole unilateral tVTA (Kaufling et al, 2010b).…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…The GABAergic tail of the ventral tegmental area (tVTA) (Kaufling et al, 2009(Kaufling et al, , 2010aPerroti et al, 2005), or rostromedial tegmental nucleus (RMTg) (Jhou et al, 2009a(Jhou et al, , 2009b, is a mesopontine structure, which exerts a major inhibitory control over dopamine cells of the VTA and substantia nigra pars compacta (SNc) (Bourdy and Barrot, 2012;Matsui et al, 2014;Sánchez-Catalán et al, 2014). The tVTA has been implicated in motor functions (Bourdy et al, 2014;Lavezzi et al, 2015), responses to drugs of abuse (Jalabert et al, 2011;Jhou et al, 2012Jhou et al, , 2013Kaufling et al, 2010b;Lavezzi et al, 2012;Lecca et al, 2011Lecca et al, , 2012Matsui and Williams, 2011;Matsui et al, 2014;Melis et al, 2014;Rotllant et al, 2010), and reward prediction error (Hong et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Response of the Tail of the Ventral Tegmental Area to Aversive Stimuli

Sánchez-Catalán

Faivre

Yalçın

et al. 2016

Neuropsychopharmacol

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The GABAergic tail of the ventral tegmental area (tVTA), also named rostromedial tegmental nucleus (RMTg), exerts an inhibitory control on dopamine neurons of the VTA and substantia nigra. The tVTA has been implicated in avoidance behaviors, response to drugs of abuse, reward prediction error, and motor functions. Stimulation of the lateral habenula (LHb) inputs to the tVTA, or of the tVTA itself, induces avoidance behaviors, which suggests a role of the tVTA in processing aversive information. Our aim was to test the impact of aversive stimuli on the molecular recruitment of the tVTA, and the behavioral consequences of tVTA lesions. In rats, we assessed Fos response to lithium chloride (LiCl), β-carboline, naloxone, lipopolysaccharide (LPS), inflammatory pain, neuropathic pain, foot-shock, restraint stress, forced swimming, predator odor, and opiate withdrawal. We also determined the effect of tVTA bilateral ablation on physical signs of opiate withdrawal, and on LPS-and LiCl-induced conditioned taste aversion (CTA). Naloxone-precipitated opiate withdrawal induced Fos in μ-opioid receptor-positive (15%) and -negative (85%) tVTA cells, suggesting the presence of both direct and indirect mechanisms in tVTA recruitment during withdrawal. However, tVTA lesion did not impact physical signs of opiate withdrawal. Fos induction was also present with repeated, but not single, foot-shock delivery. However, such induction was mostly absent with other aversive stimuli. Moreover, tVTA ablation had no impact on CTA. Although stimulation of the tVTA favors avoidance behaviors, present findings suggest that this structure may be important to the response to some, but not all, aversive stimuli.

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The antero-posterior heterogeneity of the ventral tegmental area

Cited by 101 publications

References 194 publications

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

Response of the Tail of the Ventral Tegmental Area to Aversive Stimuli

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