Sensory irritation potential of selected nasal tumorigens in the rat

Aldehydes

“…However, epithelial cell damage was more frequent in rats than mice, where respiratory rate was decreased following exposure to much lower FA concentrations in mice (Chang et al, 1981(Chang et al, , 1983. Sensory irritation does not protect against all types of nasal carcinogens, as some potent carcinogens are only weak irritants (Gardner et al, 1985). Thus, sensory irritation can be regarded as a protective mechanism that tends to limit exposure to aldehydes at concentrations that could elicit a toxic response.…”

Hexamethylphosphorsäure‐triamid [MAK Value Documentation in German language, 2010]

“…Die Exposition hatte keine Auswirkungen auf die Atemfrequenz (Gardner et al 1985). Die Exposition hatte keine Auswirkungen auf die Atemfrequenz (Gardner et al 1985).…”

Aldehydes

“…Thus, sensory irritation can be regarded as a protective mechanism that tends to limit exposure to aldehydes at concentrations that could elicit a toxic response. Sensory irritation does not protect against all types of nasal carcinogens, as some potent carcinogens are only weak irritants (Gardner et al 1985).…”