Sensorineural hearing loss in a case of congenital Zika virus

Leal, Mariana de Carvalho; Muniz, Lílian Ferreira; Neto, Sílvio da Silva Caldas; Linden, Vanessa van der; Ramos, Regina Coeli Ferreira

doi:10.1016/j.bjorl.2016.06.001

Cited by 56 publications

(60 citation statements)

References 3 publications

(3 reference statements)

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“…Nevertheless, recent findings in children with CZS pointed possibility that conductive hearing loss may not be related to Zika virus infection, since the hearing loss caused by congenital viral infections would be sensorineural loss. 12 These issues need to be reviewed and assessed in greater depth in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…3,6,[8][9][10] However, few studies have addressed auditory aspects associated with congenital Zika virus infection. [11][12] A recent study, involving infants with microcephaly in Pernambuco, reported a proportion of 4/69 for unilateral or bilateral sensorineural hearing loss, 13 compatible with hearing losses caused by congenital viral infections. However, cases involving sensorineural hearing loss due to congenital viral infection, usually bilateral, severe and profound, are often undetectable at birth, since such loss can be progressive.…”

Section: Introductionmentioning

confidence: 99%

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Triagem auditiva de crianças com síndrome congênita pelo vírus Zika atendidas em Fortaleza, Ceará, 2016

Leite¹,

Santos²,

Ribeiro³

et al. 2018

Epidemiologia e Serviços de Saúde

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Objective: to describe the results of hearing screening performed in children with Congenital Zika Virus Syndrome (CZS) in Fortaleza, Ceará, Brazil. Methods: this was a descriptive cross-sectional study involving children with CZS receiving health care in Fortaleza, 2016; the hearing screening tests performed were immittance audiometry, transient otoacoustic emissions (TOAE), acoustic reflexes, and cochleopalpebral reflex (CPR). Results: The study included 45 children with an average age of 10 months. 44 of them underwent tympanometric screening, with 16 of these having the right ear within the normal range and 22 having the left ear within the normal range. Among the 43 children evaluated by TOAE, 30 "passed" in both ears, nine "refered" in both ears and four "refered" just in ear; 13/43 "refered" and needed to repeat screening. 43 children evaluated by CPR, 37 showed responses. Conclusion: most of the children evaluated had completed cochlear function and middle ear results refer in compatible with their age range.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Triagem auditiva de crianças com síndrome congênita pelo vírus Zika atendidas em Fortaleza, Ceará, 2016

Leite¹,

Santos²,

Ribeiro³

et al. 2018

Epidemiologia e Serviços de Saúde

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“…Across studies, 56 (21.2%) of 264 individuals were found to have some degree of HL. 18,[22][23][24][25][26][27][28][29][30][31][32][33][34] Four of the fourteen articles described acquired HL in adults following Zika infection ( Table 1). The HL in these cases varied from moderate to severe and was reported as both unilateral and bilateral, with most patients experiencing recovery to normal or previous thresholds.…”

Section: Resultsmentioning

confidence: 99%

“…[22][23][24]30 Ten articles presented complication data of congenital Zika syndrome related to HL (Table 1). 18,22,[25][26][27][28][29][33][34][35] The majority of these studies used standard HL screening methods for infants, including measurement of auditory brainstem response and otoacoustic emission, which assesses cochlear function. 18,[25][26][27][28][29]31,33,34 The proportion of infants with reported HL in these studies varied from 6% to 68%.…”

Section: Resultsmentioning

confidence: 99%

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever

Ficenec

Schieffelin

Emmett

2019

The American Journal of Tropical Medicine and Hygiene

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The neglected tropical diseases Zika, Ebola, and Lassa fever (LF) have all been noted to cause some degree of hearing loss (HL). Hearing loss is a chronic disability that can lead to a variety of detrimental effects, including speech and language delays in children, decreased economic productivity in adults, and accelerated cognitive decline in older adults. The objective of this review is to summarize what is known regarding HL secondary to these viruses. Literature for this review was gathered using the PubMed database. Articles were excluded if there were no data of the respective viruses, postinfectious complications, or conditions related to survivorship. A total of 50 articles were included in this review. Fourteen articles discussing Zika virus and subsequent complications were included. Across these studies, 56 (21.2%) of 264 Zika-infected individuals were found to have HL. Twenty-one articles discussing Ebola virus and subsequent complications were included, with 190 (5.7%) of 3,350 Ebola survivors found to have HL. Fifteen additional articles discussing LF and subsequent complications were included. Of 926 individuals with LF, 79 (8.5%) were found to have HL. These results demonstrate a relationship between HL and infection. The true prevalence is likely underestimated, however, because of lack of standardization of reporting and measurement. Future studies of viral sequelae would benefit from including audiometric evaluation. This information is critical to understanding pathophysiology, preventing future cases of this disability, and improving quality of life after survival of infection.

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“…This disease is also associated with other signs and symptoms, such as visual and auditory alterations and symptoms that are uncommon in congenital infections, such as arthrogryposis (Chimelli et al, ; Eickmann et al, ). With regard to neuroimaging, cortical/subcortical calcifications, cortical malformations, ventriculomegaly and cerebral hypoplasia have been reported (Aragão et al, ; Del Carpio‐Orantes, Rosas‐Lozano, & García‐Méndez, ; Eickmann et al, ; Leal, Muniz, Caldas Neto, Van der Linden, & Ramos, ).…”

Section: Discussionmentioning

confidence: 99%

Orthopedic findings in arthrogryposis and congenital Zika syndrome: A case series

Serpa¹,

Melo

Lins³

et al. 2019

Birth Defects Research

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Background Congenital arthrogryposis (CA) consists of congenital joint contractures that affect at least two joints in different parts of the body. Approximately, 80% of CA cases are neurogenic, with changes to the formation, structure or functioning of the central and/or peripheral nervous systems. Most abnormalities are triggered either by motoneurons decreased activation in the corticospinal tract or by direct motoneurons injury. There had been few reports in the literature correlating congenital infection in humans with arthrogryposis until 2015. CA has recently been described associated with congenital Zika syndrome (CZS). Methods The objective of this study was to investigate and describe accurately the arthrogrypotic alterations in infants diagnosed with CZS and thus, suggest a possible pattern of orthopedic impairment. A total of 198 medical records of infants with CZS were evaluated. According to inclusion and exclusion criteria, 17 infants were included in the present study. Arthrogrypotic joints were orthopedically evaluated in four segments: right, left, upper, and lower limbs. All the four segments were assessed independently. Results Flexed wrists were the most frequently observed manifestation, associated with ulnar deviation (35.29%). Deformities were also commonly found in the third and fourth fingers (64.70%). Hip dislocation was found in 58.82% of the patients and talipes equinovarus and equinovalgus ankles were found in 29.41 and 23.52%. Conclusion There was a particular pattern of joint impairment related to CZS and arthogrypotic alterations of infants evaluated in this study.

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Sensorineural hearing loss in a case of congenital Zika virus

Cited by 56 publications

References 3 publications

Triagem auditiva de crianças com síndrome congênita pelo vírus Zika atendidas em Fortaleza, Ceará, 2016

Triagem auditiva de crianças com síndrome congênita pelo vírus Zika atendidas em Fortaleza, Ceará, 2016

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever

Orthopedic findings in arthrogryposis and congenital Zika syndrome: A case series

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