Triagem auditiva de crianças com síndrome congênita pelo vírus Zika atendidas em Fortaleza, Ceará, 2016

Leite, Rebeka Ferreira Pequeno; Santos, Marinisi Sales Aragão; Ribeiro, Erlane Marques; Pessoa, André Luiz Santos; Lewis, Dóris Ruthy; Giacheti, Célia Maria; Cavalcanti, Luciano Pamplona de Góes

doi:10.5123/s1679-49742018000400002

Cited by 11 publications

(12 citation statements)

References 14 publications

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“…Considering the age of evaluation of these cases (between 30 to 42 months), the prevalence can be considered high [ 32 ]. This outcome was also that reported in the study by Leite et al [ 33 ] and may be indicative of altered immune responses and/or the presence of structural changes in the middle ear, raising the possibility that CZVI is a predisposing factor for this occurrence.…”

Section: Discussionsupporting

confidence: 86%

Auditory and Language Development Assessment of Newborns Aged One to Four Years Exposed to Gestational Zika Virus Infection: A Case Series

Gonik

Oliveira

Chagas

et al. 2021

IJERPH

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The known neurotropism of the Zika virus (ZikV) suggests that auditory organs and their neural pathways may be affected by prenatal Zika infections. Among the possible manifestations are audiological and language disorders, but so far, the data in the literature are inconclusive. Objective: To describe early and late hearing disorders in children with Congenital Zika Virus Infection (CZVI) and evaluate the language development of this population between 14 and 47 months of age and its possible correlation with the alterations found in auditory exams. Methods: Longitudinal, prospective, observational study of newborns born in Juiz de Fora and its macroregion with confirmed diagnosis of ZikV infection during pregnancy. Participants were examined from one to four years of age for hearing using the transient otoacoustic emissions (TOAE) test, immittance testing and brainstem auditory evoked potential (BAEP), and language using the Bayley Scales of Infant Development—Third Edition (Bayley III). Results: 15 participants were included; eight (53.33%) presented alterations in at least one of the hearing tests, one had an early loss (6%) of sensorineural origin, and seven (46.67%) had a poor language performance. In the three (20%) participants whose audiological exams were altered, there was language impairment, and two (13.33%) participants had extensive malformations in the central nervous system (CNS), presented language delay, and hearing exams were within normality. Conclusion: Infants and preschoolers with CZVI may present early neurosensory loss and late hearing loss with fluctuating character. Even if there were no significant association between the audiological exams results and the Bayley III performance, in the present sample, language development was below expectations for the age in the participants who had alterations in the three audiological exams, when there is early hearing loss or extensive lesions to the CNS. The results reinforce the importance of audiological examinations, especially the BAEP morphological and auditory threshold, in monitoring cases of CZVI until at least three years of age.

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Section: Discussionsupporting

confidence: 86%

Auditory and Language Development Assessment of Newborns Aged One to Four Years Exposed to Gestational Zika Virus Infection: A Case Series

Gonik

Oliveira

Chagas

et al. 2021

IJERPH

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“…In another study conducted with a sample of 43 children with CZVS, there was an absence of responses in the TOAE in 13 of them 21 . With the TOAEs, it was possible to analyze the cochlear function quickly, objectively, and non-invasively; this procedure being very important in clinical practice to perform the crosscheck 20,26 .…”

Section: Discussionmentioning

confidence: 88%

“…As in Brazil, this infection evokes the need for studies that investigate various aspects of children's development, such as audiological assessment and monitoring of the affected population 10 . Few studies describing the effects of congenital infection on hearing with a significant sample can be found in the literature 8,12,21 . In the long run, new research results may contribute to the understanding of these problems.…”

Section: Discussionmentioning

confidence: 99%

Resultados audiológicos em um grupo de crianças com microcefalia pela síndrome congênita do Zika virus

Rosa

Lewis

2020

Audiol., Commun. Res.

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RESUMO Objetivo investigar a audição de crianças com microcefalia pela síndrome congênita do Zika vírus. Métodos a amostra foi composta de 11 crianças com microcefalia causada pela síndrome congênita do Zika vírus. A coleta teve início no primeiro semestre de 2017, sendo finalizada no primeiro semestre de 2018. Procedimentos realizados: avaliação otorrinolaringológica e audiológica: observação do comportamento auditivo e audiometria de reforço visual; imitanciometria, emissões otoacústicas evocadas por estímulo transiente, potencial evocado auditivo de tronco encefálico por via áerea e potencial evocado auditivo por estado estável com estímulo narrow band CE-chirp. As respostas comportamentais foram comparadas com as respostas do potencial evocado auditivo de estado estável. Resultados apresentaram respostas dentro do esperado para idade, na avaliação comportamental 11 crianças, com 20 dB bilateralmente para tons calibrados em campo, nas frequências de 500 Hz, 1 kHz, 2 kHz e 4 kHz, sendo que 2 delas conseguiram realizar a audiometria em campo com fone de inserção bilateralmente. Em relação às emissões otoacústicas, todas tiveram respostas presentes em ambas as orelhas, 10 crianças apresentaram timpanometria tipo A e uma (1) do tipo Ar. Quanto ao potencial evocado auditivo, as 8 crianças avaliadas apresentaram resultados dentro da normalidade, com nível mínimo de respostas em 20 dBNAn bilateralmente. No potencial evocado auditivo de estado estável, 6 crianças avaliadas apresentaram nível mínimo derespostas em 500 Hz, 1 kHz, 2 kHz e 4kHz, em 20 dBNAn, bilateralmente. Conclusão as crianças avaliadas não apresentaram perda auditiva neurossensorial.

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“…All studies that performed ophthalmological evaluations exposed some alteration, such as microphthalmia, fundoscopic alterations, macular atrophy, optic nerve abnormalities, strabismus and visual acuity defects (12,14,27,36,45,50,51,56,60,61,67,68,(73)(74)(75)(76)(77)(78)(79). Twelve of 14 papers that evaluated audiological manifestations in children reported hearing disorders (11,14,27,36,37,39,43,51,56,60,62,64) and two did not observe any abnormalities (30,41).…”

Section: Resultsmentioning

confidence: 99%

“…In a cross-sectional study, when evaluating 45 children with a mean age of 10 months, Leite et al ( 41 ) found no association between exposure to ZIKV during pregnancy and audiological alterations. Similarly, when comparing children exposed and not exposed to ZIKV, Fandiño-Cárdenas et al ( 30 ), in their cohort study of 66 exposed children did not observe hearing loss in the first two years of life.…”

Section: Discussionmentioning

confidence: 99%

Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review

Amaral¹,

Malacarne²,

Brandão³

et al. 2021

Front. Psychiatry

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Background: Vertical transmission of Zika Virus (ZIKV) can be associated with several clinical features in newborn infants. The goal of the present review was to analyze the current state of knowledge regarding clinical repercussions following perinatal exposure to ZIKV in children up to 3 years of age.Methods: A systematic review of published studies was carried out, without the restriction of language or date of publication, identified in the databases PubMed, Virtual Health Library (BVS), Scopus, and Web of Science and the catalog for CAPES theses and dissertations. According to the proposed flowchart, the bibliographic search resulted in 1,563 papers. Of these, according to the eligibility criteria, 70 were selected for systematic review; all were published between 2016 and 2021.Results: Regarding clinical findings, 19 papers evaluated clinical imaging alterations, 21 ophthalmic manifestations, and 39 evaluated the central nervous system; of these, 15 analyzed neuro-psychomotor development. The remainder evaluated audiological (n = 14), nutritional (n = 14), orthopedic (n = 7), cardiorespiratory (n = 5), genitourinary (n = 3) or endocrinological (n = 1) manifestations.Conclusion: It is critical for studies to continue monitoring children with antenatal ZIKV exposure as they grow, given the unknown long-term repercussions of ZIKV and the recognized postnatal complications of this infection during pregnancy. Broader descriptions of observed clinical findings are also important in order to characterize the entire spectrum of disease in children.Systematic Review Registration: PROSPERO REGISTER: CRD42020205947.

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Triagem auditiva de crianças com síndrome congênita pelo vírus Zika atendidas em Fortaleza, Ceará, 2016

Cited by 11 publications

References 14 publications

Auditory and Language Development Assessment of Newborns Aged One to Four Years Exposed to Gestational Zika Virus Infection: A Case Series

Auditory and Language Development Assessment of Newborns Aged One to Four Years Exposed to Gestational Zika Virus Infection: A Case Series

Resultados audiológicos em um grupo de crianças com microcefalia pela síndrome congênita do Zika virus

Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review

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