Sensorimotor gating and habituation evoked by electro-cutaneous stimulation in schizophrenia

Bolino, Francesca; Michele, Vittorio Di; Cicco, Loredana Di; Manna, Vincenzo; Daneluzzo, E.; Casacchia, M

doi:10.1016/0006-3223(94)91176-2

Cited by 146 publications

(81 citation statements)

References 28 publications

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“…Several psychiatric and neurological disorders, including schizophrenia, [1][2][3][4][5][6][7][8] obsessive compulsive disorder, 9,10 Huntington's disease 11 and Tourette's syndrome, [12][13][14] show marked deficits in information processing and filtering of stimuli. Specifically, sensorimotor gating, which involves the inhibition of a motor response by the presence of a sensory event, is impaired in these individuals.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice

2008

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It has been previously suggested that oxytocin (Oxt) may act as a natural antipsychotic. To test this hypothesis, we investigated whether disruption of the oxytocin gene (OxtÀ/À) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP). We examined drug-induced changes in the prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating deficits characteristic of several psychiatric and neurological disorders, including schizophrenia. We found that treatment with Amp, Apo and PCP all had effects on PPI. However, in OxtÀ/À mice, but not Oxt þ / þ mice, PCP treatment resulted in large PPI deficits. As PCP is a noncompetitive N-methyl-D-aspartic acid receptor antagonist, these findings suggest that the absence of Oxt alters the glutamatergic component of the PPI.

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Section: Introductionmentioning

confidence: 99%

Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice

2008

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“…Schizophrenics have impairments in PPI (Braff et al 1978;Braff et al 1992;Grillon et al 1992;Bolino et al 1994;Parwani et al 2000). PPI is similarly impaired in animals following treatment with the NMDA antagonists PCP, MK-801, or ketamine (Mansbach and Geyer 1989;Mansbach 1991;Keith et al 1991;Swerdlow et al 1993;Johansson et al 1995;al-Amin and Schwartzkopf 1996).…”

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confidence: 99%

Clinical and Sensorimotor Gating Effects of Ketamine in Normals

Duncan

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Parwani

et al. 2001

Neuropsychopharmacology

142

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“…PPI models a form of preattentional sensorimotor gating and is reduced in psychiatric disorders characterized by deficient sensorimotor gating, such as schizophrenia (Braff et al 1978Grillon et al 1992;Bolino et al 1994).…”

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confidence: 99%