Sensorimotor Cortical Activity during Respiratory Arousals in Obstructive Sleep Apnea

Bahr, Katharina; Koirala, Nabin; Hanif, Marsha; Gouveris, Haralampos

doi:10.3390/ijms24010047

Cited by 2 publications

References 56 publications

(63 reference statements)

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Defining, Detecting and Assessment of Microstructures in Different Stages of Sleep Apnea Transients Using ECG and EEG Features in CSA and OSA Patients

Koçak

Telatar

Ficici

et al. 2023

Preprint

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The sleep recordings of 32 patients with obstructive sleep apnea (OSA) and central sleep apnea (CSA) were analyzed with signal processing and statistical methods. The aim of the present study was to analyze electrocardiogram (ECG) and electroencephalogram (EEG) signals, along with other polysomnography (PSG) outcomes, according to sleep stages, sleep apnea types, and apnea/hypopnea index, and to demonstrate their association with EEG microstructures that cannot be detected visually. Patients were classified into groups according to the apnea/hypopnea index (AHI) and, results were classified according to types of apnea, and the apneas that were detected during all sleep stages (N1-N2-N3 and REM). ECG and EEG signals were analyzed with time-frequency methods. Analysis was carried out during epoch at apnea (intra-apnea), epoch before apnea (pre-apnea), and epoch after apnea (post-apnea). The findings of the present study are presented as different tables in the Results and Discussion sections, and were discussed in the Conclusion section.

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Defining, Detecting and Assessment of Microstructures in Different Stages of Sleep Apnea Transients Using ECG and EEG Features in CSA and OSA Patients

Koçak

Telatar

Ficici

et al. 2023

Preprint

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Insomnia in Patients Undergoing Hypoglossal Nerve Stimulation Therapy for Obstructive Sleep Apnea

Pordzik¹,

Ludwig²,

Seifen³

et al. 2023

Biology

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Hypoglossal nerve stimulation (HGNS) is a treatment for obstructive sleep apnea (OSA) patients with intolerance of positive airway pressure therapy. Comorbid insomnia is quite prevalent in OSA patients. We investigated the impact of insomnia and excessive daytime sleepiness (EDS) on polysomnography metrics after HGNS treatment. Data of 27 consecutive patients (9 female; mean age 55.52 ± 8.6 years) were retrospectively evaluated. Insomnia was assessed using the ISI (insomnia severity index) and EDS using the Epworth sleepiness scale (ESS). The median ISI was reduced significantly 3 months after HGNS activation (preoperative: 19; postoperative: 14; p < 0.01). Significant inverse correlations emerged between preoperative ISI and postoperative AHI (apnea/hypopnea index; Spearman’s rho = −0.4, p < 0.05), ∆ AHI (r = −0.51, p < 0.01) and ∆ ODI (oxygen desaturation index; r = −0.48, p < 0.05). ISI correlated strongly with EES both preoperatively (r = 0.46; p < 0.02) and postoperatively (r = 0.79; p < 0.001). Therefore, HGNS therapy is associated with a significant reduction of insomnia-related symptoms, in addition to the improvement in respiratory metrics in OSA. Nonetheless, the preoperative severity of patient-reported insomnia symptoms was inversely correlated with the respiratory PSG-outcomes after HGNS. Insomnia should be considered in studies of EDS in OSA patients, especially those treated with HGNS.

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Sensorimotor Cortical Activity during Respiratory Arousals in Obstructive Sleep Apnea

Cited by 2 publications

References 56 publications

Defining, Detecting and Assessment of Microstructures in Different Stages of Sleep Apnea Transients Using ECG and EEG Features in CSA and OSA Patients

Defining, Detecting and Assessment of Microstructures in Different Stages of Sleep Apnea Transients Using ECG and EEG Features in CSA and OSA Patients

Insomnia in Patients Undergoing Hypoglossal Nerve Stimulation Therapy for Obstructive Sleep Apnea

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