Sensor to detect endothelialization on an active coronary stent

Musick, Katherine M.; Coffey, Arthur C.; Irazoqui, Pedro P.

doi:10.1186/1475-925x-9-67

Cited by 9 publications

(13 citation statements)

References 21 publications

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“…As a result of their excellent performance MCLs have recently emerged for the detection not only of small molecules, but also of nucleic acids, disease marker proteins [103][104][105], cells [106] and different bacteria or viruses [107,108].…”

Section: Microcantileversmentioning

confidence: 99%

Microcantilevers and organic transistors: two promising classes of label-free biosensing devices which can be integrated in electronic circuits

et al. 2011

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Most of the success of electronic devices fabricated to actively interact with a biological environment relies on the proper choice of materials and efficient engineering of surfaces and interfaces. Organic materials have proved to be among the best candidates for this aim owing to many properties, such as the synthesis tunability, processing, softness and self-assembling ability, which allow them to form surfaces that are compatible with biological tissues. This review reports some research results obtained in the development of devices which exploit organic materials' properties in order to detect biologically significant molecules as well as to trigger/capture signals from the biological environment. Among the many investigated sensing devices, organic field-effect transistors (OFETs), organic electrochemical transistors (OECTs) and microcantilevers (MCLs) have been chosen. The main factors motivating this choice are their label-free detection approach, which is particularly important when addressing complex biological processes, as well as the possibility to integrate them in an electronic circuit. Particular attention is paid to the design and realization of biocompatible surfaces which can be employed in the recognition of pertinent molecules as well as to the research of new materials, both natural and inspired by nature, as a first approach to environmentally friendly electronics.

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Section: Microcantileversmentioning

confidence: 99%

Microcantilevers and organic transistors: two promising classes of label-free biosensing devices which can be integrated in electronic circuits

et al. 2011

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“…(b) In-stent restenosis develops with the re-occurrence of fatty deposition (as shown in yellow) in the stenotic region. (c) After stent is implanted, delayed endothelialization or endothelial denudation leads to the migration of smooth muscle cells from the middle layer of blood vessel leading to smooth muscle cell proliferation and neointimal hyperplasia Musick, Coffey, and Irazoqui (2010) (Munawar et al, 2019;Ye, Lee, & Feng, 2017), mass analysis in the range of mega-to gigadalton range including that of most viruses and disease biomarkers is possible (Dominguez-Medina et al, 2018;Gil-Santos et al, 2010). In nanoscale, the response of such nanoresonators depends not only on the mass of the adsorbed cells but also on the mechanical properties of those cells (Ramos, Tamayo, Mertens, Calleja, & Zaballos, 2006).…”

Section: F I G U R Ementioning

confidence: 99%

“…Prognostic relevance of endothelial coverage to check the incidence of late stent thrombosis is well established, and monitoring of endothelialization can assist in the early detection of stent thrombosis. Musick, Coffey, and Irazoqui (2010) developed a self‐actuating, self‐sensing piezoelectric sensor based on a plasma‐treated hydrophilic parylene‐coated micro‐cantilever. When endothelial cells come in contact with the sensors attached on the stent surface, the effective mass and surface charge will vary, thereby altering the resonance frequency of the micro‐cantilever providing information regarding stent endothelialization.…”

Section: Smart Stents To Detect Endothelializationmentioning

confidence: 99%

Perspectives on smart stents with sensors: From conventional permanent to novel bioabsorbable smart stent technologies

Vishnu

Manivasagam

2020

Med Devices & Sens

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Percutaneous coronary intervention with the aid of cardiovascular stents is the widely used therapeutic procedure for treating occlusive vascular diseases associated with the plaque deposition inside blood vessels. In spite of the momentous evolution and innovations in the field of medical technologies as well as biomaterial science, cardiovascular stents are still associated with several limitations. The introduction of bare metal stents, which revolutionized the field of interventional cardiology, was later hampered by the occurrence of restenosis (recurrence of arterial narrowing after surgery) and target lesion revascularization (repeated percutaneous intervention or revascularization within a stent) (Nordrehaug, Wiseth, & Bønaa, 2016; Piccolo et al., 2019). Repeated attempts to correct stenotic regions can often result in rupture of vessel that can elicit blood clot formation (thrombosis) or even lead to life-threatening haemorrhage (Farooq and Gogas Bill, 2011). Restenosis occurrence originating from proliferative neointimal tissue growth in response to strut-related injury and inflammation can be clinically evident typically within 6-9 months after stent placement (Alfonso, Byrne, Rivero, & Kastrati, 2014; Moliterno, 2005). In order to specifically address the restenosis problem, the first-generation drug-eluting stents with a drug-loaded (paclitaxel) polymer coating on a metallic platform (316L stainless steel) were de

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“…Some authors developed a few years ago a self-actuating, self-sensing device for detecting the presence of endothelial cells on a surface of a coronary stent in order to detect when the struts have been covered with a layer of endothelial cells (42). The aim of this in-vitro study was to develop a tool that would allow for an anti-platelet therapy adaptation in real-time with regards to the patient's level of healing.…”

Section: What's Next?mentioning

confidence: 99%

Role of animal models for percutaneous atrial septal defect closure

Jalal¹,

Séguéla²,

Baruteau³

et al. 2018

J. Thorac. Dis.

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As for any preclinical development of new implantable device, bench testing has been followed by experimental studies on large animal models for the development of atrial septal defect closure devices. Various models have been used according to studied species (porcine, ovine or canine model) and whether the septal defect was percutaneously or surgically created. Animal models of percutaneous atrial septal defect closure aim to assess the healing process and device endothelialisation, as well as the development of magnetic resonance imaging guided procedures, the short-term effects of volume overload on right ventricular contractility through haemodynamic studies and the understanding of other complications such as nickel hypersensitivity. Each technique has its own advantages and drawbacks, and leads to different punch-related, acute septal injuries that could have an effect on the healing process after device implantation. It has been suggested that some long-term, major device-related complications such as thrombosis or infective endocarditis may be associated with an inappropriate healing process or insufficient endothelialisation of the device, leading industrial companies to pay a great deal of attention to the healing process. Tissue reactions in animal models were shown to adequately reproduce the healing response after device implantation in humans, with an endothelial device coverage observed as early as 30 days after implantation and complete after 3 to 6 months. Research perspectives may evaluate both animal models and in-vitro studies in parallel with a view to clarify the endothelialisation process using human endothelial cells through in-vitro experiments. Self-sensing device for detecting the presence of endothelial cells on the surface of intracardiac occluders and high-resolution imaging techniques that could non-invasively assess the complete endothelialisation of a device would also be promising tools which would need large animal models studies before their clinical application.

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Sensor to detect endothelialization on an active coronary stent

Cited by 9 publications

References 21 publications

Microcantilevers and organic transistors: two promising classes of label-free biosensing devices which can be integrated in electronic circuits

Microcantilevers and organic transistors: two promising classes of label-free biosensing devices which can be integrated in electronic circuits

Perspectives on smart stents with sensors: From conventional permanent to novel bioabsorbable smart stent technologies

Role of animal models for percutaneous atrial septal defect closure

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