Sensitization to methyl methacrylate in the plastic catheter of an insulin pump infusion set

Clinical review: insulin pump-associated adverse events in adults and children

“…Catheter sites that remain in place for some days may result in skin reactions [29], and cases of allergic contact dermatitis (to a variety of set/site components), and bacterial infection, have been reported [13,30]. Scarring and lipohypertrophy appear common but have mainly cosmetic effects [28], whereas lipoatrophy, once common, is beginning to be seen again (see below).…”

Sensitization to cyanoacrylates caused by prolonged exposure to a glucose sensor set in a diabetic child

“…Monitoring of blood glucose and administration of insulin are pivotal in the treatment of type 1 diabetes mellitus in children. Adverse effects such as skin problems caused by glucose sensor sets or insulin pumps are rarely reported . We present a child with newly diagnosed type 1 diabetes mellitus who developed allergic contact dermatitis caused by contact allergy to a cyanoacrylate used in the glue for the fabric parts of a glucose sensor set.…”

Adhesives Used for Diabetes Medical Devices

“…Such systems have been in use for decades and it appears as if the adhesives have been optimized over time, though some reports about skin reactions exist. 9,10 Do we have reliable data about skin reactions? This requires a more detailed view:…”

“…As mentioned above, a few reports already exist about contact dermatitis induced by acrylate-based adhesives from diabetes medical devices. 4,9,10 The glue used in adhesives usually consists of an acrylate polymer which is a mixture of mostly 3 different acrylate monomers. While polymerized acrylates are usually called nonirritant and hypoallergenic, monomers are considered as strong skin sensibilizer, 12,13 acrylates were also named the "Contact Allergen of the Year" by the American Contact Dermatitis Society in 2012.…”