Sensitization to cyanoacrylates caused by prolonged exposure to a glucose sensor set in a diabetic child

Isobornyl acrylate contained in the insulin patch pump OmniPod as the cause of severe allergic contact dermatitis

“…The authors found that 1 of the culprit allergens was IBOA . Recently, it was shown that ACD caused by glucose monitoring systems can also be related to cyanoacrylates . In this particular case, ethyl cyanoacrylate was shown to be a component of the thin layer of glue fixing the sensor to the adhesive.…”

Allergic contact dermatitis and diabetes medical devices: 2 clinical cases

“…The increasing use of advanced devices for diabetes treatment, such as continuous subcutaneous insulin infusion, flash glucose monitoring, continuous glucose monitoring systems, and sensor‐augmented pumps, has resulted in important improvements in disease management, especially in terms of prevention of hypoglycaemic events and minimizing intraday glycaemic variability. However, some recent reports have described ACD caused by components contained in the adhesive tapes used to attach these devices to the skin of patients with diabetes . Cutaneous symptoms could be related to a worsening of glycaemic control, and therefore necessitate a change in insulin administration method(s), with a switch to more invasive multiple injection therapy.…”

Adhesives Used for Diabetes Medical Devices

“…Such issues are known from other patients that need a prolonged supply by adhesives such as, for example, stoma patients or patients with longer postsurgical closure, 2,3 but was also observed with a CGM system. 4 Beside a longer wearing time of an adhesive, there may be other factors that predispose for developing a type 4 allergy. Definitely, the potency of the sensitizer is most crucial, but also individual aspects such as a non-intact skin barrier of the individual is also most critical for developing a contact allergy.…”