Sensitization to apomorphine in pigeons

Delius, Juan D.; Acerbo, Martín J.; Krug, Ines; Lee, Jennifer; Leydel, Rita

doi:10.1097/fbp.0000000000000087

Cited by 3 publications

(1 citation statement)

References 125 publications

(157 reference statements)

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“…Glutamatergic activity is critical to the learning associations known to occur between cocaine and environmental cues (Harris and Aston-Jones, 2003). Previous work in pigeons has suggested that Pavlovian conditioning plays a role in drug-induced behavioral sensitization (Acerbo et al , 2003; Acerbo and Delius, 2004; Braga et al , 2009; Delius et al , 2015). Acerbo et al (2004) blocked sensitization to apomorphine using the N-methyl D-aspartate receptor antagonist, MK-801, suggesting that coactivation of DA and glutamate is required for sensitization to occur.…”

Section: Discussionmentioning

confidence: 99%

D2 receptor antagonism enhances cocaine-induced behavioral sensitization in female, but not male Japanese quail (Coturnix japonica)

Gill

McGarrigle

Neel

et al. 2022

Behavioural Pharmacology

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Sex differences in cocaine-induced behaviors are well established. In rodents, females show enhanced locomotion to cocaine over multiple trials compared with males, a behavioral response known as sensitization. Estradiol enhances cocaine-induced sensitization in female rats by agonizing dopaminergic activity within the brain. In female quail, cocaine does not increase locomotion regardless of increased estradiol. A higher D2:D1 dopamine receptor ratio in quail compared with rodents may explain this sex and species difference. The goal of the present work was to investigate the role of D2 receptors in cocaine-induced locomotion and sensitization in Japanese quail and to determine whether a greater D2 receptor availability contributed to the lack of cocaineinduced sensitization in female quail found in previous studies. Male and female quail were administered 0, 0.03, 0.05, or 0.07 mg/kg of eticlopride (Eti) followed by 10 mg/kg of cocaine or saline then immediately placed in open-field chambers. Distance traveled was recorded for 30 min daily for 7 days. In female quail, cocaine-induced sensitization was observed with 0.03 or 0.05 mg/kg Eti, but not in cocaine-only females. In male quail, cocaineinduced sensitization was observed similar to previous research. However, Eti did not enhance cocaine-induced locomotion or produce sensitization in male quail. The D2 receptor likely mediates cocaine's motor stimulating effects in quail. In females, this effect is more pronounced. Since high D2 availability is protective against stimulant abuse, Japanese quail may be a useful model for investigating the role of the D2 receptor in cocaine addiction, but further research is needed. Behavioural

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Section: Discussionmentioning

confidence: 99%

D2 receptor antagonism enhances cocaine-induced behavioral sensitization in female, but not male Japanese quail (Coturnix japonica)

Gill

McGarrigle

Neel

et al. 2022

Behavioural Pharmacology

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Long-term behavioral sensitization to apomorphine is independent of conditioning and increases conditioned pecking, but not preference, in pigeons

Anselme

Edes

Tabrik

et al. 2018

Behavioural Brain Research

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A dose–response study of separate and combined effects of the serotonin agonist 8-OH-DPAT and the dopamine agonist quinpirole on locomotor sensitization, cross-sensitization, and conditioned activity

Johnson

Szechtman²

2016

Behavioural Pharmacology

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Chronic treatment with the dopamine D2/D3 agonist, quinpirole, or the serotonin 1A agonist, 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), induces behavioral sensitization. It is not known whether both drugs produce sensitization through a shared mechanism. Here, we examine whether quinpirole and 8-OH-DPAT show cross-sensitization and impact sensitization, as would be expected from shared mechanisms. Male rats (N=208) were assigned randomly to 16 groups formed by crossing four doses of quinpirole (0, 0.03125, 0.0625, or 0.125 mg/kg) with four doses of 8-OH-DPAT (0, 0.03125, 0.625, or 0.125 mg/kg). After a course of 10 drug treatments administered twice per week in locomotor activity chambers, all groups were challenged on separate tests with quinpirole (0.1 mg/kg), 8-OH-DPAT (0.1 mg/kg), or saline, and locomotor activity was evaluated. Challenge tests with quinpirole and 8-OHDPAT showed no cross-sensitization between the drugs. Chronic quinpirole (0.125 mg/kg) administration induced a sensitized quinpirole response that was attenuated dose-dependently by chronic 8-OH-DPAT cotreatment. Cotreatment with quinpirole (0.0625 mg/kg) and 8-OH-DPAT (all doses) induced quinpirole sensitization. Chronic 8-OH-DPAT (0.125 mg/kg) induced a sensitized 8-OHDPAT response that was prevented by chronic cotreatment with the lowest but not the highest dose of quinpirole. Cotreatment with 8-OHDPAT (0.0625) and quinpirole (0.125 mg/kg) induced sensitization to 8-OH-DPAT. The saline challenge test showed elevated locomotor activity in chronic quinpirole (0.125 mg/kg) and 8-OHDPAT (0.0625, 0.125 mg/kg) alone groups, and in seven of nine cotreated groups. The absence of cross-sensitization suggests separate mechanisms of sensitization to quinpirole and 8-OH-DPAT. Cotreatment effects suggest that induction of sensitization can be modulated by serotonin 1A and D2/D3 activity.

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Sensitization to apomorphine in pigeons

Cited by 3 publications

References 125 publications

D2 receptor antagonism enhances cocaine-induced behavioral sensitization in female, but not male Japanese quail (Coturnix japonica)

D2 receptor antagonism enhances cocaine-induced behavioral sensitization in female, but not male Japanese quail (Coturnix japonica)

Long-term behavioral sensitization to apomorphine is independent of conditioning and increases conditioned pecking, but not preference, in pigeons

A dose–response study of separate and combined effects of the serotonin agonist 8-OH-DPAT and the dopamine agonist quinpirole on locomotor sensitization, cross-sensitization, and conditioned activity

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